American Journal of Ophthalmology
Volume 146, Issue 3 , Pages 346-347.e1 , September 2008

Distinguishing Between Infectious and Noninfectious Endophthalmitis After Intravitreal Triamcinolone Injection

  • Daniel B. Roth

      Affiliations

    • Robert Wood Johnson Medical School, New Brunswick, New Jersey
    • Corresponding Author InformationInquiries to Daniel B. Roth, Robert Wood Johnson, School of Medicine, Retina Vitreous Center, 125 Paterson Street, New Brunswick, NJ 08701
    • ,
  • Harry W. Flynn Jr

      Affiliations

    • University of Miami, Miller School of Medicine, Miami, Florida

,Accepted 29 April 2008.

References 

  1. McCuen BW, Bessler M, Tano Y, Chandler D, Machemer R. The lack of toxicity of intravitreally administered triamcinolone acetonide. Am J Ophthalmol. 1981;91:785–788
  2. Penfold PL, Gyory JF, Hunyor AB, Bilson FA. Exudative macular degeneration and intravitreal triamcinolone (A pilot study). Aust NZ J Ophthalmol. 1995;23:293–298
  3. Roth DB, Chieh J, Spirn MJ, et al. Noninfectious endophthalmitis associated with intravitreal triamcinolone injection. Arch Ophthalmol. 2003;121:1279–1282
  4. Westfall AC, Osbom A, Kuhl D, et al. Acute endophthalmitis incidence: intravitreal triamcinolone. Arch Ophthalmol. 2005;123:1075–1077
  5. Jonas JB, Kreissig I, Spandau UH, Harder B. Infectious and noninfectious endophthalmitis after intravitreal high-dosage triamcinolone acetonide. Am J Ophthalmol. 2006;141:579–580
  6. Bucher RS, Hall E, Reed DM, et al. Effect of intravitreal triamcinolone acetonide on susceptibility to experimental bacterial endophthalmitis and subsequent response to treatment. Arch Ophthalmol. 2005;123:649–653
  7. Lalwani GA, Flynn HW, Scott IU, et al. Acute-onset endophthalmitis after clear corneal cataract surgery (1996–2005): Clinical features, causative organisms, and visual acuity outcomes. Ophthalmology. 2008;115:473–476
  8. Jonas JB. Effects of triamcinolone acetonide injections with and without preservative. Br J Ophthalmol. 2007;91:1099–1101
  9. Shaikh S, Ho S, Engelmann LA, Klemann SW. Cell viability effects of triamcinolone acetonide and preservative vehicle formulations. Br J Ophthalmol. 2006;90:233–236
  10. Yu SY, Damko FM, Viola F, D'Amico DJ, Young LH. Retinal toxicity of intravitreal triamcinolone acetonide: a morphological study. Retina. 2006;26:531–536
  11. Roth DB, Prenner JL, Krajnyk O. The incidence of noninfectious endophthalmitis after intravitreal preservative-free triamcinolone acetonide. Retin Cases Brief Rep. Forthcoming.
  12. Nguyen JK, Fung AE, Flynn HW JR, Scott IU. Hypopyon and pseudoendophthalmitis associated with chronic vitreous hemorrhage. Ophthalmic Surg Lasers Imaging. 2006;37:317–319
  13. Shields JA, Shields CL, Eagle RC, Blair CJ. Spontaneous pseudohypopyon secondary to diffuse infiltrating retinoblastoma. Arch Ophthalmol. 1988;106:1301–1302
  14. Sharma MC, Lai WW, Shapiro MJ. Pseudohypopyon following intravitreal triamcinolone acetonide injection. Cornea. 2004;23:398–399
  15. Chen SD, Lockhead J, Patel CK. Diffuse intraocular dispersion of triamcinolone particles as a cause of sterile endophthalmitis. Arch Ophthalmol. 2004;122:1733

 Supplemental Material available at AJO.com.

PII: S0002-9394(08)00342-5

doi: 10.1016/j.ajo.2008.04.037

American Journal of Ophthalmology
Volume 146, Issue 3 , Pages 346-347.e1 , September 2008

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