American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 151-153 , August 2008

Retinal Pigment Epithelium–Retina Transplantation for Retinal Degenerative Disease

  • Marco Attilio Zarbin

      Affiliations

    • Corresponding Author InformationInquiries to Marco Attilio Zarbin, Doctors Office Center, 90 Bergen Street, Room 6155, Newark, NJ 07103

,Accepted 16 May 2008.

References 

  1. Radtke ND, Aramant RB, Petry HM, Green PT, Pidwell DJ, Sellers MJ. Vision improvement in retinal degeneration patients by implantation of retina together with retinal pigment epithelium. Am J Ophthalmol. 2008;146:172–182
  2. Geller AM, Sieving PA. How many cones are required to “see”?: lessons from Stargardt's macular dystrophy and from modeling with degenerate photoreceptor arrays. In:  Hollyfield JG,  Anderson RE,  LaVeil MM editor. Retinal Degeneration. New York, New York: Plenum Press; 1993;p. 25–34
  3. Roorda A, Zhang Y, Duncan JL. High-resolution in vivo imaging of the RPE mosaic in eyes with retinal disease. Invest Ophthalmol Vis Sci. 2007;48:2297–2303
  4. Mahmoud TH, McCuen BW, Hao Y, et al. Lensectomy and vitrectomy decrease the rate of photoreceptor loss in rhodopsin P347L transgenic pigs. Graefes Arch Clin Exp Ophthalmol. 2003;241:298–308
  5. Kaneko H, Nishiguchi KM, Nakamura M, Kachi S, Terasaki H. Retardation of photoreceptor degeneration in the detached retina of rd1 mouse. Invest Ophthalmol Vis Sci. 2008;49:781–787
  6. Ghosh F, Engelsberg K, English RV, Petters RM. Long-term neuroretinal full-thickness transplants in a large animal model of severe retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol. 2007;245:835–846
  7. Jaenisch R, Young R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell. 2008;132:567–582
  8. Castellarin AA, Nasir MA, Sugino IK, Zarbin MA. Progressive presumed choriocapillaris atrophy after surgery for age-related macular degeneration. Retina. 1998;18:143–149
  9. Lund RD, Adamson P, Sauve Y, et al. Subretinal transplantation of genetically modified human cell lines attenuates loss of visual function in dystrophic rats. Proc Natl Acad Sci U S A. 2001;98:9942–9947
  10. Chalmel F, Leveillard T, Jaillard C, et al. Rod-derived cone viability factor-2 is a novel bifunctional-thioredoxin-like protein with therapeutic potential. BMC Mol Biol. 2007;8:74
  11. Maguire AM, Simonelli F, Pierce EA, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med. 2008;358:2240–2248
  12. Bainbridge JWB, Smith AJ, Barker SS, et al. Effect of gene therapy on visual function in Leber's congenital amaurosis. N Engl J Med. 2008;358:2231–2239
  13. Klassen HJ, Ng TF, Kurimoto Y, et al. Multipotent retinal progenitors express developmental markers, differentiate into retinal neurons, and preserve light-mediated behavior. Invest Ophthalmol Vis Sci. 2004;45:4167–4173
  14. MacLaren RE, Pearson RA, MacNeil A, et al. Retinal repair by transplantation of photoreceptor precursors. Nature. 2006;444:203–207
  15. Seiler MJ, Sagdullaev BT, Woch G, Thomas BB, Aramant RB. Transsynaptic virus tracing from host brain to subretinal transplants. Eur J Neurosci. 2005;21:161–172
  16. Tao S, Young C, Redenti S, et al. Survival, migration and differentiation of retinal progenitor cells transplanted on micro-machined poly(methyl methacrylate) scaffolds to the subretinal space. Lab Chip. 2007;7:695–701
  17. Jones BW, Watt CB, Frederick JM, et al. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol. 2003;464:1–16
  18. Gullapalli VK, Khodair M, Wang H, Sugino IK, Madreperla S, Zarbin MA. Retinal pigment epithelium and photoreceptor transplantation frontiers. In:  Ryan SJ editors. Retina. 4th ed.. Philadelphia, Pennsylvania: Elsevier Mosby, Inc; 2006;p. 2597–2613

 See accompanying Article on page 172.

PII: S0002-9394(08)00413-3

doi: 10.1016/j.ajo.2008.05.027

American Journal of Ophthalmology
Volume 146, Issue 2 , Pages 151-153 , August 2008

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