One hundred and nine healthy subjects from the Advanced Imaging in Glaucoma Study were enrolled in this study. All subjects had a standard clinical examination, including visual field (VF) and good-quality scans from all three imaging devices. CCT was measured using an ultrasonic pachymeter. A linear mixed-effects model was used to assess the relationship between RNFL thickness and CCT, accounting for clustering of eyes within subjects, testing site, ethnicity, family history of glaucoma, axial length intraocular pressure, and VF global indices.
Results
For OCT and GDx, there was a slight nonstatistically significant positive relationship between CCT and RNFL thickness. For HRT, there was a slight nonstatistically significant negative relationship between CCT and RNFL thickness. Relationships for each device were found to differ between sites.
Conclusions
CCT was not statistically significantly related to RNFL thickness in healthy eyes.
UPMC Eye Center, Ophthalmology and Visual Science Research Center, Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania
Inquiries to Joel S. Schuman, UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Eye and Ear Institute, Suite 816, Pittsburgh, PA 15213
ABSTRACT