Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study

Francis, Brian A.; Varma, Rohit; Chopra, Vikas; Lai, Mei-Ying; Shtir, Corina; Azen, Stanley P.; Los Angeles Latino Eye Study Group,

doi:10.1016/j.ajo.2008.05.048

« Previous Next »American Journal of Ophthalmology
Volume 146, Issue 5 , Pages 741-746, November 2008

Intraocular Pressure, Central Corneal Thickness, and Prevalence of Open-Angle Glaucoma: The Los Angeles Latino Eye Study

Brian A. Francis
- Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California
Rohit Varma
- Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
- Inquiries to Rohit Varma, Doheny Eye Institute, 1450 San Pablo Street, Suite 4900, Los Angeles, CA 90033
Vikas Chopra
- Doheny Eye Institute, Keck School of Medicine, University of Southern California, Los Angeles, California
Mei-Ying Lai
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
Corina Shtir
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
Stanley P. Azen
- Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
Los Angeles Latino Eye Study Group

Accepted 31 May 2008. published online 30 July 2008.

Purpose

To examine the relationship between the prevalence of open-angle glaucoma (OAG) and intraocular pressure (IOP) and the impact of central corneal thickness (CCT) on this relationship.

Design

Population-based cross-sectional study.

Methods

The study cohort consisted of 5,970 participants from the Los Angeles Latino Eye Study (LALES) with no history of glaucoma treatment and with complete ophthalmic examination data. The relationship between the prevalence of OAG and IOP was contrasted across persons with CCT designated as thin, normal, or thick.

Results

Prevalence of OAG was exponentially related to IOP. When stratified by CCT, persons with thin CCT had a significantly higher prevalence of OAG than did those with normal or thick CCTs at all levels of IOP. Adjusting each IOP individually for CCT did not impact significantly the relationship between the prevalence of OAG and IOP.

Conclusions

These findings suggest that adjusting for the impact of CCT on IOP by correction algorithms is not necessary in a population based assessment of glaucoma prevalence; CCT, however, is an important independent risk factor for the prevalence of OAG.