American Journal of Ophthalmology
Volume 146, Issue 5 , Pages 735-740.e2 , November 2008

Anatomic Relationships between Disc Hemorrhage and Parapapillary Atrophy

  • Nathan M. Radcliffe

      Affiliations

    • Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    • Department of Ophthalmology, New York University, New York, New York
    • Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York, New York
  • ,
  • Jeffrey M. Liebmann

      Affiliations

    • Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    • Department of Ophthalmology, New York University, New York, New York
    • Department of Ophthalmology, Manhattan Eye, Ear and Throat Hospital, New York, New York
    • Corresponding Author InformationInquiries to Jeffrey M. Liebmann, 310 East 14th Street, New York, NY 10003
  • ,
  • Ilya Rozenbaum

      Affiliations

    • Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • ,
  • Zaher Sbeity

      Affiliations

    • Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • ,
  • Shlomit F. Sandler

      Affiliations

    • Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • ,
  • Celso Tello

      Affiliations

    • Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
  • ,
  • Robert Ritch

      Affiliations

    • Einhorn Clinical Research Center, New York Eye and Ear Infirmary, New York, New York
    • Department of Ophthalmology, The New York Medical College, Valhalla, New York

,Accepted 17 June 2008.

References 

  1. Harper R, Reeves B. The sensitivity and specificity of direct ophthalmoscopic optic disc assessment in screening for glaucoma: a multivariate analysis. Graefes Arch Clin Exp Ophthalmol. 2000;238:949–955
  2. Theodossiades J, Murdoch I. What optic disc parameters are most accurately assessed using the direct ophthalmoscope?. Eye. 2001;15:283–287
  3. Jonas JB, Budde WM, Panda-Jonas S. Ophthalmoscopic evaluation of the optic nerve head. Surv Ophthalmol. 1999;43:293–320
  4. Jonas JB, Stroux A, Oberacher-Velten IM, Kitnarong N, Jünemann A. Central corneal thickness and development of glaucomatous optic disk hemorrhages. Am J Ophthalmol. 2005;140:1139–1141
  5. Drance SM, Fairclough M, Butler DM, Kottler MS. The importance of disc hemorrhage in the prognosis of chronic open-angle glaucoma. Arch Ophthalmol. 1977;95:226–228
  6. Siegner SW, Netland PA. Optic disc hemorrhages and progression of glaucoma. Ophthalmology. 1996;103:1014–1024
  7. Ishida K, Yamamoto T, Sugiyama K, Kitazawa Y. Disk hemorrhage is a significantly negative prognostic factor in normal-tension glaucoma. Am J Ophthalmol. 2000;129:707–714
  8. Jonas JB, Xu L. Optic disk hemorrhages in glaucoma. Am J Ophthalmol. 1994;118:1–8
  9. Airaksinen PJ, Mustonen E, Alanko HI. Optic disc hemorrhages precede retinal nerve fiber layer defects in ocular hypertension. Acta Ophthalmol (Copenh). 1981;59:627–641
  10. Jonas JB, Schiro D. Localised wedge shaped defects of the retinal nerve fiber layer in glaucoma. Br J Ophthalmol. 1994;78:285–290
  11. Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z EMGT Group. Predictors of long-term progression in the early manifest glaucoma trial. Ophthalmology. 2007;114:1965–1972
  12. Budenz DL, Anderson DR, Feuer WJ, et al. Ocular Hypertension Treatment Study Group Detection and prognostic significance of optic disc hemorrhages during the Ocular Hypertension Treatment Study. Ophthalmology. 2006;113:2137–2143
  13. Ahn JK, Kang JH, Park KH. Correlation between a disc hemorrhage and peripapillary atrophy in glaucoma patients with a unilateral disc hemorrhage. J Glaucoma. 2004;13:9–14
  14. Sugiyama K, Tomita G, Kawase K, et al. Disc hemorrhage and peripapillary atrophy in apparently healthy subjects. Acta Ophthalmol Scand. 1999;77:139–142
  15. Sugiyama K, Uchida H, Tomita G, Sato Y, Iwase A, Kitazawa Y. Localized wedge-shaped defects of retinal nerve fiber layer and disc hemorrhage in glaucoma. Ophthalmology. 1999;106:1762–1767
  16. Healey PR, Mitchell P, Smith W, Wang JJ. Optic disc hemorrhages in a population with and without signs of glaucoma. Ophthalmology. 1998;105:216–223
  17. Yamamoto T, Iwase A, Kawase K, Sawada A, Ishida K. Optic disc hemorrhages detected in a large-scale eye disease screening project. J Glaucoma. 2004;13:356–360
  18. Hayakawa T, Sugiyama K, Tomita G, et al. Correlation of the peripapillary atrophy area with optic disc cupping and disc hemorrhage. J Glaucoma. 1998;7:306–311
  19. Lan YW, Wang IJ, Hsiao YC, Sun FJ, Hsieh JW. Characteristics of disc hemorrhage in primary angle-closure glaucoma. Ophthalmology. Forthcoming.
  20. Krupin T, Liebmann JM, Greenfield DS, Rosenberg LF, Ritch R, Yang JW Low-Pressure Glaucoma Study Group. The Low-Pressure Glaucoma Treatment Study (LoGTS) study design and baseline characteristics of enrolled patients. Ophthalmology. 2005;112:376–385
  21. Soares AS, Artes PH, Andreou P, Leblanc RP, Chauhan BC, Nicolela MT. Factors associated with optic disc hemorrhages in glaucoma. Ophthalmology. 2004;111:1653–1657
  22. Roberts TV, Gregory-Roberts JC. Optic disc hemorrhages in posterior vitreous detachment. Aust N Z J Ophthalmol. 1991;19:61–63
  23. Kubota T, Jonas JB, Naumann GO. Direct clinico-histological correlation of parapapillary chorioretinal atrophy. Br J Ophthalmol. 1993;77:103–106
  24. Jonas JB, Naumann GO. Parapapillary chorioretinal atrophy in normal and glaucoma eyes. (II. Correlations). Invest Ophthalmol Vis Sci. 1989;30:919–926
  25. Primrose J. The incidence of the peripapillary halo glaucomatosus. Trans Ophthalmol Soc U K. 1970;89:585–587
  26. Wilensky JT, Kolker AE. Peripapillary changes in glaucoma. Am J Ophthalmol. 1976;81:341–345
  27. Daugeliene L, Yamamoto T, Kitazawa Y. Risk factors for visual field damage progression in normal-tension glaucoma eyes. Graefes Arch Clin Exp Ophthalmol. 1999;237:105–108
  28. Rockwood EJ, Anderson DR. Acquired peripapillary changes and progression in glaucoma. Graefes Arch Clin Exp Ophthalmol. 1988;226:510–515
  29. Jonas JB, Nguyen XN, Gusek GC, Naumann GO. Parapapillary chorioretinal atrophy in normal and glaucoma eyes. (I. Morphometric data). Invest Ophthalmol Vis Sci. 1989;30:908–918
  30. Jonas JB, Naumann GO. Parapapillary chorioretinal atrophy in normal and glaucoma eyes. (II. Correlations). Invest Ophthalmol Vis Sci. 1989;30:919–926
  31. Uhm KB, Lee DY, Kim JT, Hong C. Peripapillary atrophy in normal and primary open-angle glaucoma. Korean J Ophthalmol. 1998;12:37–50
  32. Xu L, Wang Y, Yang H, Jonas JB. Differences in parapapillary atrophy between glaucomatous and normal eyes: the Beijing Eye Study. Am J Ophthalmol. 2007;144:541–546
  33. Jonas JB. Clinical implications of peripapillary atrophy in glaucoma. Curr Opin Ophthalmol. 2005;16:84–88
  34. Heltzer JM. Progression of peripapillary atrophy. Ophthalmology. 1999;106:857
  35. Uchida H, Ugurlu S, Caprioli J. Increasing peripapillary atrophy is associated with progressive glaucoma. Ophthalmology. 1998;105:1541–1545
  36. Law SK, Choe R, Caprioli J. Optic disk characteristics before the occurrence of disk hemorrhage in glaucoma patients. Am J Ophthalmol. 2001;132:411–413
  37. Jonas JB, Martus P, Budde WM. Inter-eye differences in chronic open-angle glaucoma patients with unilateral disc hemorrhages. Ophthalmology. 2002;109:2078–2083
  38. Jonas JB, Martus P, Budde WM, Hayler J. Morphologic predictive factors for development of optic disc hemorrhages in glaucoma. Invest Ophthalmol Vis Sci. 2002;43:2956–2961
  39. Sugiyama K, Tomita G, Kitazawa Y, Onda E, Shinohara H, Park KH. The associations of optic disc hemorrhage with retinal nerve fiber layer defect and peripapillary atrophy in normal-tension glaucoma. Ophthalmology. 1997;104:1926–1933
  40. Gazzard G, Morgan W, Devereux J, et al. Optic disc hemorrhage in Asian glaucoma patients. J Glaucoma. 2003;12:226–231
  41. Raitta C, Sarmela T. Fluorescein angiography of the optic disc and the peripapillary area in chronic glaucoma. Acta Ophthalmol (Copenh). 1970;48:303–308
  42. Jonas JB, Budde WM, Németh J, Gründler AE, Mistlberger A, Hayler JK. Central retinal vessel trunk exit and location of glaucomatous parapapillary atrophy in glaucoma. Ophthalmology. 2001;108:1059–1064
  43. Flammer J. The vascular concept of glaucoma. Surv Ophthalmol. 1994;38:S3–S6
  44. Xu L, Wang Y, Yang H, Jonas JB. Differences in parapapillary atrophy between glaucomatous and normal eyes: the Beijing Eye Study. Am J Ophthalmol. 2007;144:541–546
  45. Rader J, Feuer WJ, Anderson DR. Peripapillary vasoconstriction in the glaucomas and the anterior ischemic optic neuropathies. Am J Ophthalmol. 1994;117:72–80
  46. Tezel G, Kass MA, Kolker AE, Wax MB. Comparative optic disc analysis in normal pressure glaucoma, primary open-angle glaucoma, and ocular hypertension. Ophthalmology. 1996;103:2105–2113
  47. Jonas J. Biomorphometry and histomorphometry of the optic disc with special reference to the parapapillary region. Bull Soc Belge Ophtalmol. 1992;244:45–60
  48. Grieshaber MC, Terhorst T, Flammer J. The pathogenesis of optic disc splinter hemorrhages: a new hypothesis. Acta Ophthalmol Scand. 2006;84:62–68
  49. Anderson DR, Drance SM, Schulzer M Collaborative Normal-Tension Glaucoma Study Group. Factors that predict the benefit of lowering intraocular pressure in normal-tension glaucoma. Am J Ophthalmol. 2003;136:820–829
  50. Tezel G, Kolker AE, Kass MA, Wax MB, Gordon M, Siegmund KD. Parapapillary chorioretinal atrophy in patients with ocular hypertension. (I. An evaluation as a predictive factor for the development of glaucomatous damage). Arch Ophthalmol. 1997;115:1503–1508

PII: S0002-9394(08)00484-4

doi: 10.1016/j.ajo.2008.06.018

American Journal of Ophthalmology
Volume 146, Issue 5 , Pages 735-740.e2 , November 2008