American Journal of Ophthalmology
Volume 146, Issue 6 , Pages 920-924 , December 2008

Effect of Blinking on Tear Volume After Instillation of Midviscosity Artificial Tears

  • Jayachandra R. Palakuru

      Affiliations

    • Bascom Palmer Eye Institute, University of Miami, Miami, Florida
    • Department of Ophthalmology, University of Rochester, Rochester, New York
  • ,
  • Jianhua Wang

      Affiliations

    • Bascom Palmer Eye Institute, University of Miami, Miami, Florida
    • Department of Ophthalmology, University of Rochester, Rochester, New York
    • Corresponding Author InformationInquiries to Jianhua Wang, Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, 1638 NW 10th Avenue, McKnight Building, Room 202A, Miami, FL 33136
  • ,
  • James V. Aquavella

      Affiliations

    • Department of Ophthalmology, University of Rochester, Rochester, New York

,Accepted 19 June 2008.

References 

  1. Palakuru JR, Wang J, Aquavella JV. Effect of blinking on tear dynamics. Invest Ophthalmol Vis Sci. 2007;48:3032–3037
  2. Maurice DM. The dynamics and drainage of tears. Int Ophthalmol Clin. 1973;13:103–116
  3. Doane MG. Blinking and the mechanics of the lacrimal drainage system. Ophthalmology. 1981;88:844–851
  4. Sorensen T, Jensen FT. Methodological aspects of tear flow determination by means of a radioactive tracer. Acta Ophthalmol (Copenh). 1977;55:726–738
  5. Sorensen T, Jensen FT. Tear flow in normal human eyes (Determination by means of radioisotope and gamma camera). Acta Ophthalmol (Copenh). 1979;57:564–581
  6. Chavis RM, Welham RA, Maisey MN. Quantitative lacrimal scintillography. Arch Ophthalmol. 1978;96:2066–2068
  7. Davies NM. Biopharmaceutical considerations in topical ocular drug delivery. Clin Exp Pharmacol Physiol. 2000;27:558–562
  8. Benedetto DA, Shah DO, Kaufman HE. The instilled fluid dynamics and surface chemistry of polymers in the preocular tear film. Invest Ophthalmol. 1975;14:887–902
  9. Wang J, Aquavella J, Palakuru J, Chung S, Feng C. Relationships between central tear film thickness and tear menisci of the upper and lower eyelids. Invest Ophthalmol Vis Sci. 2006;47:4349–4355
  10. Wang J, Aquavella J, Palakuru J, Chung S. Repeated measurements of dynamic tear distribution on the ocular surface after instillation of artificial tears. Invest Ophthalmol Vis Sci. 2006;47:3325–3329
  11. Tiffany JM, Todd BS, Baker MR. Computer-assisted calculation of exposed area of the human eye. Adv Exp Med Biol. 1998;438:433–439
  12. Johnson ME, Murphy PJ. Temporal changes in the tear menisci following a blink. Exp Eye Res. 2006;83:517–525
  13. Mishima S, Gasset A, Klyce SD, Baum JL. Determination of tear volume and tear flow. Invest Ophthalmol. 1966;5:264–276
  14. Mainstone JC, Bruce AS, Golding TR. Tear meniscus measurement in the diagnosis of dry eye. Curr Eye Res. 1996;15:653–661
  15. Zhu H, Chauhan A. A mathematical model for tear drainage through the canaliculi. Curr Eye Res. 2005;30:621–630
  16. Zhu H, Chauhan A. A mathematical model for ocular tear and solute balance. Curr Eye Res. 2005;30:841–854
  17. Acosta MC, Gallar J, Belmonte C. The influence of eye solutions on blinking and ocular comfort at rest and during work at video display terminals. Exp Eye Res. 1999;68:663–669
  18. Paulsen FP, Schaudig U, Thale AB. Drainage of tears: impact on the ocular surface and lacrimal system. Ocul Surf. 2003;1:180–191
  19. Baxter SA, Laibson PR. Punctal plugs in the management of dry eyes. Ocul Surf. 2004;2:255–266
  20. Simmons PA, Vehige JG. Clinical performance of a mid-viscosity artificial tear for dry eye treatment. Cornea. 2007;26:294–302
  21. Sahlin S, Laurell CG, Chen E, Philipson B. Lacrimal drainage capacity, age, and blink rate. Orbit. 1998;17:155–159
  22. Sahlin S, Chen E. Gravity, blink rate, and lacrimal drainage capacity. Am J Ophthalmol. 1997;124:758–764
  23. Wong H, Fatt I, Radke CJ. Deposition and thinning of the human tear film. J Colloid Interface Sci. 1996;184:44–51
  24. King-Smith PE, Fink BA, Hill RM, Koelling KW, Tiffany JM. The thickness of the tear film. Curr Eye Res. 2004;29:357–368
  25. Nichols JJ, Mitchell GL, King-Smith PE. Thinning rate of the precorneal and prelens tear films. Invest Ophthalmol Vis Sci. 2005;46:2353–2361
  26. Braun RJ, Fitt AD. Modeling drainage of the precorneal tear film after a blink. Math Med Biol. 2003;20:1–28

PII: S0002-9394(08)00508-4

doi: 10.1016/j.ajo.2008.06.020

American Journal of Ophthalmology
Volume 146, Issue 6 , Pages 920-924 , December 2008