American Journal of Ophthalmology
Volume 147, Issue 6 , Pages 1048-1054.e2 , June 2009

Dexamethasone Posterior-Segment Drug Delivery System in the Treatment of Macular Edema Resulting from Uveitis or Irvine-Gass Syndrome

  • George A. Williams

      Affiliations

    • Beaumont Eye Institute, Royal Oak, Michigan
    • Corresponding Author InformationInquiries to George A. Williams, 3535 West 13 Mile Road, Royal Oak, MI 48073
    • ,
  • Julia A. Haller

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland
    • ,
  • Baruch D. Kuppermann

      Affiliations

    • University of California, Irvine, Irvine, California
    • ,
  • Mark S. Blumenkranz

      Affiliations

    • Stanford University, Stanford, California
    • ,
  • David V. Weinberg

      Affiliations

    • Medical College of Wisconsin, Milwaukee, Wisconsin
    • ,
  • Connie Chou

      Affiliations

    • Allergan Inc, Irvine, California
    • ,
  • Scott M. Whitcup

      Affiliations

    • Allergan Inc, Irvine, California
    • ,
  • The Dexamethasone DDS Phase II Study Group

,Accepted 29 December 2008.

References 

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  11. Young S, Larkin G, Branley M, Lightmann S. Safety and efficacy of intravitreal triamcinolone for cystoid macular oedema in uveitis. Clin Experiment Ophthalmol. 2001;29:2–6
  12. Martidis A, Duker JS, Greenberg PB, et al. Intravitreal triamcinolone for refractory diabetic macular edema. Ophthalmology. 2002;109:920–927
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  15. Kuppermann BD, Blumenkranz MS, Haller JA, et al. Randomized controlled study of an intravitreous dexamethasone drug delivery system in patients with persistent macular edema. Arch Ophthalmol. 2007;125:309–317
  16. Fung WE. Vitrectomy for chronic aphakic cystoid macular edema: results of a national, collaborative, prospective, randomized investigation. Ophthalmology. 1985;92:1102–1111
  17. Whitcup SM, Csaky KG, Podgor MJ, et al. A randomized, masked, cross-over trial of acetazolamide for cystoid macular edema in patients with uveitis. Ophthalmology. 1996;103:1054–1062
  18. Early Treatment Diabetic Retinopathy Study Research Group. Early treatment diabetic retinopathy study design and baseline patient characteristics: ETDRS Report No. 7. Ophthalmology. 1991;98:741–756
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  20. Butcher J, Austin M, McGalliard J, Bourke R. Bilateral cataracts and glaucoma induced by long-term use of steroid eye drops. Br Med J. 1994;309:43
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  22. Becker B. Intraocular pressure response to topical corticosteroids. Invest Ophthalmol Vis Sci. 1965;4:198–205
  23. Van Kooij B, Rothova A, de Vries P. The pros and cons of intravitreal triamcinolone injections for uveitis and inflammatory cystoid macular edema. Ocul Immunol Inflamm. 2006;14:73–85
  24. Goldstein DA, Godfrey DG, Hall A, et al. Intraocular pressure in patients with uveitis treated with fluocinolone acetonide implants. Arch Ophthalmol. 2007;125:1478–1485

 Supplemental Material available at AJO.com.

 Julia A. Haller is currently affiliated with Wills Eye Hospital, Philadelphia, Pennsylvania. Connie Chou is currently affiliated with Eisai Medical Research Inc, Ridgefield Park, New Jersey

PII: S0002-9394(09)00002-6

doi: 10.1016/j.ajo.2008.12.033

American Journal of Ophthalmology
Volume 147, Issue 6 , Pages 1048-1054.e2 , June 2009

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