American Journal of Ophthalmology
Volume 148, Issue 2 , Pages 242-248.e1, August 2009

Comparison of Clinically Relevant Findings from High-Speed Fourier-Domain and Conventional Time-Domain Optical Coherence Tomography

  • Pearse A. Keane

      Affiliations

    • Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
  • ,
  • Rizwan A. Bhatti

      Affiliations

    • Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
  • ,
  • Jacob W. Brubaker

      Affiliations

    • Department of Ophthalmology, University of Utah, Salt Lake City, Utah
  • ,
  • Sandra Liakopoulos

      Affiliations

    • Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Cologne, Germany
  • ,
  • Srinivas R. Sadda

      Affiliations

    • Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
  • ,
  • Alexander C. Walsh

      Affiliations

    • Doheny Image Reading Center, Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
    • Corresponding Author InformationInquiries to Alexander C. Walsh, Doheny Eye Institute, 1450 San Pablo Street, Los Angeles, CA 90033

Accepted 3 March 2009. published online 11 May 2009.

Purpose

To compare the sensitivities of high-speed Fourier-domain optical coherence tomography (FD-OCT) and conventional time-domain (TD) OCT for the detection of clinical findings important in the management of common vitreoretinal disorders.

Design

Prospective, observational study.

Methods

FD-OCT scans (128 B scans × 512 A scans) were obtained using a prototype instrument (3 D-OCT; Topcon, Tokyo, Japan) in 50 eyes of 28 consecutive patients undergoing conventional high-resolution (6 B scans × 512 A scans) TD-OCT imaging (Stratus OCT; Carl Zeiss Meditec, Dublin, California, USA). Each image set was reviewed independently for the presence of clinical findings of interest, and device sensitivities were calculated.

Results

The average sensitivity for detection of all features in this study was 94% for FD-OCT and 60% for TD-OCT. Clinical findings were identical between devices in 18% (9/50) of cases. FD-OCT detected features that were not visible on conventional OCT scans in 78% (39/50) of cases. FD-OCT was more sensitive than TD-OCT for the detection of multiple findings, including diffuse intraretinal edema (87% vs 60.9%), subretinal fluid (100% vs 46.2%), large pigment epithelium detachments (100% vs 81%), and subretinal tissue (100% vs 61.5%).

Conclusions

FD-OCT seems to be superior to TD-OCT for the detection of many clinically relevant features of vitreoretinal disease. The greater sensitivity of FD-OCT systems for the detection of intraretinal and subretinal fluid may be of particular importance for the treatment of patients with neovascular age-related macular edema. FD-OCT is likely to supplant TD-OCT as the standard of care for retinal specialists in the near future.

To access this article, please choose from the options below

Login to an existing account or Register a new account.

  • Purchase this article for 31.50 USD (You must login/register to purchase this article)

    Online access for 24 hours. The PDF version can be downloaded as your permanent record.

  • Subscribe to this title

    Get unlimited online access to this article and all other articles in this title 24/7 for one year.

  • Claim access now

    For current subscribers with Society Membership or Account Number.

  • Visit SciVerse ScienceDirect to see if you have access via your institution.
 

PII: S0002-9394(09)00159-7

doi:10.1016/j.ajo.2009.03.004

American Journal of Ophthalmology
Volume 148, Issue 2 , Pages 242-248.e1, August 2009