American Journal of Ophthalmology
Volume 148, Issue 3 , Pages 439-444.e1 , September 2009

Correlation between Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence at the Margins of Geographic Atrophy

,Accepted 21 April 2009.

References 

  1. Ferris FL, Fine SL, Hyman L. Age-related macular degeneration and blindness due to neovascular maculopathy. Arch Ophthalmol. 1984;102:1640–1642
  2. Friedman DS, O'Colmain BJ, Munoz B, et al. Prevalence of age-related macular degeneration in the United States. Arch Ophthalmol. 2004;122:564–572
  3. Weiter JJ, Delori FC, Wing GL, Fitch KA. Retinal pigment epithelial lipofuscin and melanin and choroidal melanin in human eyes. Invest Ophthalmol Vis Sci. 1986;27:145–152
  4. O'Gorman S, Flaherty WA, Fishman GA, Berson EL. Histopathologic findings in Best's vitelliform macular dystrophy. Arch Ophthalmol. 1988;106:1261–1268
  5. Steinmetz RL, Garner A, Maguire JI, Bird AC. Histopathology of incipient fundus flavimaculatus. Ophthalmology. 1991;98:953–956
  6. Holz FG, Pauleikhoff D, Klein R, Bird AC. Pathogenesis of lesions in late age-related macular disease. Am J Ophthalmol. 2004;137:504–510
  7. Sarks JP, Sarks SH, Killingsworth MC. Evolution of geographic atrophy of the retinal pigment epithelium. Eye. 1988;2:552–577
  8. Holz FG, Bellmann C, Margaritidis M, et al. Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol. 1999;237:145–152
  9. Holz FG, Bellman C, Staudt S, et al. Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2001;42:1051–1056
  10. Bindewald A, Schmitz-Valckenberg S, Jorzik JJ, et al. Classification of abnormal fundus autofluorescence patterns in the junctional zone of geographic atrophy in patients with age-related macular degeneration. Br J Ophthalmol. 2005;89:874–878
  11. Drexler W, Sattmann H, Hermann B, et al. Enhanced visualization of macular pathology with the use of ultra-high resolution optical coherence tomography. Arch Ophthalmol. 2003;121:695–706
  12. Ruggeri M, Wehbe H, Jiao S, et al. In vivo three-dimensional high-resolution imaging of rodent retina with spectral-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2007;48:1808–1814
  13. Sunness JS, Gonzalez-Baron J, Applegate CA, et al. Enlargement of atrophy and visual acuity loss in the geographic atrophy form of age-related macular degeneration. Ophthalmology. 1999;106:1768–1779
  14. Kozak I, Morrison VL, Clark TM, et al. Discrepancy between fluorescein angiography and optical coherence tomography in detection of macular disease. Retina. 2008;28:538–544
  15. Freeman WR, Bartsch DU, Mueller AJ, et al. Simultaneous indocyanine green and fluorescein angiography using a confocal scanning laser ophthalmoscope. Arch Ophthalmol. 1998;116:455–463
  16. Bartsch DU, El-Bradey MH, El-Musharaf A, Freeman WR. Improved visualisation of choroidal neovascularisation by scanning laser ophthalmoscope using image averaging. Br J Ophthalmol. 2005;89:1026–1030
  17. Garcia CR, Rivero ME, Bartsch DU, et al. Oral fluorescein angiography with the confocal scanning laser ophthalmoscope. Ophthalmology. 1999;106:1114–1118
  18. Crafoord S, Dafgard Kopp E, Seregard S, Algvere PV. Cellular migration into neural retina following implantation of melanin granules in the subretinal space. Graefes Arch Clin Exp Ophthalmol. 2000;238:682–689
  19. Rakoczy PE, Zhang D, Robertson T, et al. Progressive age-related changes similar to age-related macular degeneration in a transgenic mouse model. Am J Pathol. 2002;161:1515–1524
  20. Bird AC, Bressler NM, Bressler SB, et al. An international classification and grading system for age-related maculopathy and age-related macular degeneration (The International ARM Epidemiological Study Group). Surv Ophthalmol. 1995;39:367–374
  21. Schatz H, McDonald HR. Atrophic macular degeneration (Rate of spread of geographic atrophy and visual loss). Ophthalmology. 1989;96:1541–1551
  22. Bressler NM, Bressler SB, West SK, et al. The grading and prevalence of macular degeneration in Chesapeake Bay watermen. Arch Ophthalmol. 1989;107:847–852
  23. Sarks JP, Sarks SH, Killingsworth MC. Evolution of soft drusen in age-related macular degeneration. Eye. 1994;8:269–283
  24. Sunness JS, Margalit E, Srikumaran D, et al. The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trials. Ophthalmology. 2007;114:271–277
  25. Wolf-Schnurrbusch UE, Enzmann V, Brinkmann CK, Wolf S. Morphologic changes in patients with geographic atrophy assessed with a novel spectral OCT-SLO combination. Invest Ophthalmol Vis Sci. 2008;49:3095–3099
  26. Maguire P, Vine AK. Geographic atrophy of the retinal pigment epithelium. Am J Ophthalmol. 1986;102:621–625
  27. Holz FG, Bindewald-Wittich A, Fleckenstein M, et al. Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration. Am J Ophthalmol. 2007;143:463–472

PII: S0002-9394(09)00315-8

doi: 10.1016/j.ajo.2009.04.022

American Journal of Ophthalmology
Volume 148, Issue 3 , Pages 439-444.e1 , September 2009