American Journal of Ophthalmology
Volume 149, Issue 2 , Pages 265-277 , 1 February 2010

Ability of New Vital Dyes to Stain Intraocular Membranes and Tissues in Ocular Surgery

  • Eduardo B. Rodrigues

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Fernando M. Penha

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Elaine de Paula Fiod Costa

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Mauricio Maia

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Eduardo Dib

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Milton Moraes Jr

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Carsten H. Meyer

      Affiliations

    • Department of Ophthalmology, University of Bonn, Bonn, Germany
    • ,
  • Octaviano Magalhaes Jr

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Gustavo Barreto Melo

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Vinicius Stefano

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Ana Beatriz Dias

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • ,
  • Michel Eid Farah

      Affiliations

    • Vision Institute (IPEPO), Department of Ophthalmology, Federal University of São Paulo, São Paulo, Brazil
    • Corresponding Author InformationInquiries to Michel Eid Farah, R. Botucatu 820, 04023-062 São Paulo SP, Brazil

,Accepted 18 August 2009.

References 

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  2. Burk SE, Da Mata AP, Snyder ME, Rosa RH, Foster RE. Indocyanine green-assisted peeling of the retinal internal limiting membrane. Ophthalmology. 2000;107:2010–2014
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  4. Gandorfer A, Haritoglou C, Gandorfer A, Kampik A. Retinal damage from indocyanine green in experimental macular surgery. Invest Ophthalmol Vis Sci. 2003;44:316–323
  5. Maia M, Margalit E, Tso MOM, et al. Effects of intravitreal indocyanine green injection in rabbits. Retina. 2004;24:69–79
  6. Rodrigues EB, Meyer CH, Farah ME, Kroll P. Mechanisms of intravitreal retinal toxicity to indocyanine green dye: implications for chromovitrectomy. Retina. 2007;27:958–970
  7. Mennel S, Meyer CH, Tietjen A, Rodrigues EB, Schmidt JC. Patent blue: a novel vital dye in vitreoretinal surgery. Ophthalmologica. 2006;220:190–193
  8. Enaida H, Hisatomi T, Hata Y, et al. Brilliant blue G selectively stains the internal limiting membrane/brilliant blue G-assisted membrane peeling. Retina. 2006;26:631–636
  9. Mennel S, Thumann G, Peter S, Meyer CH, Kroll P. Influence of vital dyes on the function of the outer blood-retinal barrier in vitro. Klin Monatsbl Augenheilkd. 2006;223:568–576
  10. Schuettauf F, Haritoglou C, May CA, et al. Administration of novel dyes for intraocular surgery: an in vivo toxicity animal study. Invest Ophthalmol Vis Sci. 2006;47:3573–3578
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  18. Hisatomi T, Enaida H, Matsumoto H, et al. Staining ability and biocompatibility of brilliant blue G: preclinical study of brilliant blue G as an adjunct for capsular staining. Arch Ophthalmol. 2006;124:514–519
  19. Haritoglou C, Yu A, Freyer W, et al. An evaluation of novel vital dyes for intraocular surgery. Invest Ophthalmol Vis Sci. 2005;46:3315–3322
  20. Enaida H, Hisatomi T, Goto Y, et al. Preclinical investigation of internal limiting membrane staining and peeling using intravitreal brilliant blue G. Retina. 2006;26:623–630
  21. Sorsby A. Vital staining of the retina: preliminary clinical note. Br J Ophthalmol. 1939;23:20–24
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  23. Czajka MP, McCuen BW, Cummings TJ, et al. Effects of indocyanine green on the retina and retinal pigment epithelium in a porcine model of retinal hole. Retina. 2004;24:275–282
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  25. Rodrigues EB, Penha FM, Costa EF, et al. Pre-clinical retinal biocompatibility of novel dyes for chromovitrectomy. Retina. 2009;29:497–510
  26. Costa EP, Rodrigues EB, Farah ME, et al. Vital dyes and light sources for chromovitrectomy: comparative assessment of osmolarity, pH, and spectrophotometry. Invest Ophthalmol Vis Sci. 2009;50:385–391

PII: S0002-9394(09)00620-5

doi: 10.1016/j.ajo.2009.08.020

American Journal of Ophthalmology
Volume 149, Issue 2 , Pages 265-277 , 1 February 2010

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