American Journal of Ophthalmology
Volume 149, Issue 2 , Pages 214-220.e3 , 1 February 2010

Late Varicella-Zoster Virus Dendriform Keratitis in Patients With Histories of Herpes Zoster Ophthalmicus

  • Allen Y.H. Hu

      Affiliations

    • Ocular Inflammatory Disease Center, Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California
    • ,
  • Erich C. Strauss

      Affiliations

    • Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco, San Francisco, California
    • ,
  • Gary N. Holland

      Affiliations

    • Ocular Inflammatory Disease Center, Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California
    • ,
  • Matilda F. Chan

      Affiliations

    • Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco, San Francisco, California
    • ,
  • Fei Yu

      Affiliations

    • Ocular Inflammatory Disease Center, Jules Stein Eye Institute and the Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California
    • ,
  • Todd P. Margolis

      Affiliations

    • Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco, San Francisco, California
    • Corresponding Author InformationInquiries to Todd P. Margolis, MD, PhD, Francis I. Proctor Foundation, Medical Sciences S-310, 513 Parnassus Ave, University of California San Francisco, San Francisco, CA 94143-0412

,Accepted 25 August 2009.

References 

  1. Marsh RJ, Fraunfelder FT, McGill JI. Herpetic corneal epithelial disease. Arch Ophthalmol. 1976;94:1899–1902
  2. Marsh RJ, Cooper M. Ophthalmic zoster: mucous plaque keratitis. Br J Ophthalmol. 1987;71:725–728
  3. Engstrom RE, Holland GN. Chronic herpes zoster virus keratitis associated with the acquired immunodeficiency syndrome. Am J Ophthalmol. 1988;105:556–558
  4. Chern KC, Conrad D, Holland GN, Holsclaw DS, Schwartz LK, Margolis TP. Chronic varicella-zoster virus epithelial keratitis in patients with acquired immunodeficiency syndrome. Arch Ophthalmol. 1998;116:1011–1017
  5. Pavan-Langston D, Yamamoto S, Dunkel EC. Delayed herpes zoster pseudodendrites (Polymerase chain reaction detection of viral DNA and a role for antiviral therapy). Arch Ophthalmol. 1995;113:1381–1385
  6. Al-Muammar A, Jackson WB. Management of ophthalmic zoster mucous plaque keratopathy: report of three cases. Can J Ophthalmol. 2004;39:74–76
  7. Leigh JF, Acharya N, Cevallos V, Margolis TP. Does asymptomatic shedding of herpes simplex virus on the ocular surface lead to false-positive diagnostic PCR results?. Br J Ophthalmol. 2008;92:435–436
  8. Hogan MJ, Kimura SJ, Thygeson P. Signs and symptoms of uveitis (I. Anterior uveitis). Am J Ophthalmol. 1959;47:155–170
  9. Liesegang TJ. Corneal complications from herpes zoster ophthalmicus. Ophthalmology. 1985;92:316–324
  10. Piebenga LW, Laibson PR. Dendritic lesions in herpes zoster ophthalmicus. Arch Ophthalmol. 1973;90:268–270
  11. Cobo LM. Corneal complications of herpes zoster ophthalmicus (Prevention and treatment). Cornea. 1988;7:50–56
  12. Hope-Simpson RE. The nature of herpes zoster: a long-term study and a new hypothesis. Proc R Soc Med. 1965;58:9–20
  13. Ragozzino MW, Melton LJ, Kurland LT, Chu CP, Perry HO. Population-based study of herpes zoster and its sequelae. Medicine (Baltimore). 1982;61:310–316
  14. Cohrs RJ, Mehta SK, Schmid DS, Gilden DH, Pierson DL. Asymptomatic reactivation and shed of infectious varicella zoster virus in astronauts. J Med Virol. 2008;80:1116–1122
  15. Mietz H, Eis-Hubinger AM, Sundmacher R, Font RL. Detection of varicella-zoster virus DNA in keratectomy specimens by use of the polymerase chain reaction. Arch Ophthalmol. 1997;115:590–594
  16. Wenkel H, Rummelt C, Rummelt V, Jahn G, Fleckenstein B, Naumann GO. Detection of varicella zoster virus DNA and viral antigen in human cornea after herpes zoster ophthalmicus. Cornea. 1993;12:131–137

 Supplemental Material available at AJO.com.

PII: S0002-9394(09)00630-8

doi: 10.1016/j.ajo.2009.08.030

American Journal of Ophthalmology
Volume 149, Issue 2 , Pages 214-220.e3 , 1 February 2010

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