American Journal of Ophthalmology
Volume 149, Issue 2 , Pages 189-193.e2 , 1 February 2010

HLA Typing in Uveitis: Use and Misuse

  • Katherine J. Zamecki

      Affiliations

    • Department of Ophthalmology, The Mount Sinai School of Medicine, New York, New York
    • ,
  • Douglas A. Jabs

      Affiliations

    • Department of Ophthalmology, The Mount Sinai School of Medicine, New York, New York
    • Department of Medicine, The Mount Sinai School of Medicine, New York, New York
    • Department of Epidemiology, The Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland
    • Corresponding Author InformationInquiries to Douglas A. Jabs, Mount Sinai Hospital, One Gustave L. Levy Place, Box 1183, New York, NY 10029

,Accepted 26 September 2009.

References 

  1. The Standardization of Uveitis Nomenclature (SUN) Working Group. Standardization of uveitis nomenclature for reporting clinical data (Results of the First International Workshop). Am J Ophthalmol. 2005;140:509–516
  2. Jabs DA, Rosenbaum JT, Foster CS, et al. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am J Ophthalmol. 2000;130:492–513
  3. Jabs DA. Treatment of ocular inflammation. Ocul Immunol Inflamm. 2004;12:163–168
  4. Tay-Kearney ML, Schwam BL, Lowder C, et al. Clinical features and associated systemic diseases of HLA-B27 uveitis. Am J Ophthalmol. 1996;121:47–56
  5. Thorne JE, Jabs DA, Peters GB, Hair D, Dunn JP, Kempen JH. Birdshot retinochoroidopathy: ocular complications and visual impairment. Am J Ophthalmol. 2005;140:145
  6. Thorne JE, Jabs DA, Kedhar SR, Peters GB, Dunn JP. Loss of visual field among patients with birdshot chorioretinopathy. Am J Ophthalmol. 2008;145:23–28
  7. Tamesis RR, Foster CS. Ocular syphilis. Ophthalmology. 1990;97:1281–1287
  8. Akpek EK, Thorne JE, Qazi FA, Do DV, Jabs DA. Evaluation of patients with scleritis for systemic disease. Ophthalmology. 2004;111:501–506
  9. Arnett FC, McClusky OE, Schacter BZ, Lordon RE. Incomplete Reiter's syndrome: discriminating features and HL-A W27 in diagnosis. Ann Intern Med. 1976;84:8–12
  10. Monnet D, Breban M, Hudry C, Dougados M, Brézin AP. Ophthalmic findings and frequency of extraocular manifestations in patients with HLA-B27 uveitis: a study of 175 cases. Ophthalmology. 2004;111:802–809
  11. Linssen A, Meenken C. Outcomes of HLA-B27-positive and HLA-B27-negative acute anterior uveitis. Am J Ophthalmol. 1995;120:351–361
  12. Rosenbaum JT. Characterization of uveitis associated with spondyloarthritis. J Rheumatol. 1989;16:792–796
  13. Fletcher RH, Fletcher SW, Wagner EH. Clinical Epidemiology: The Essentials. 2nd ed.. Baltimore: Williams & Wilkins; 1988;
  14. Szklo M, Nieto FJ. Epidemiology: Beyond the Basics. Gaithersburg: Aspen; 2000;
  15. Nussenblatt RB, Mittal KK, Ryan S, et al. Birdshot retinochoroidopathy associated with HLA-A29 antigen and immune responsiveness to retinal S-antigen. Am J Ophthalmol. 1982;94:147–158
  16. Priem HA, Kijlstra A, Noens L, Baarsma GS, De Laey JJ, Oosterhuis JA. HLA typing in birdshot chorioretinopathy. Am J Ophthalmol. 1988;105:182–185
  17. LeHoang P, Ozdemir N, Benhamou A, et al. HLA-A29.2 subtype associated with birdshot retinochoroidopathy. Am J Ophthalmol. 1992;113:33–35
  18. Oruc S, Kaplan AD, Galen M, Kaplan HJ. Uveitis referral pattern in a Midwest University Eye Center. Ocul Immunol Inflamm. 2003;11:287–298
  19. LeHoang P, Ryan SJ. Birdshot retinochoroidopathy. In:  Pepose JS,  Holland GN,  Withelms KR editor. Ocular Infection and Immunity. St. Louis: Mosby-Year Book; 1996;p. 570–578
  20. Levinson RD, Brezin A, Rothova A, Accorinti M, Holland GN. Research criteria for the diagnosis of birdshot chorioretinopathy: results of an international consensus conference. Am J Ophthalmol. 2006;141:185–187
  21. Oruc S, Duffy BF, Mohanakumar T, Kaplan HJ. The association of HLA class II with pars planitis. Am J Ophthalmol. 2001;131:657–659
  22. Greiner KH, Wilson DWL, Thomson J, et al. Genetic polymorphism of HLA DR in a Scottish population of patients with pars planitis. Eur J Ophthalmol. 2003;13:433–438
  23. Raja SC, Jabs DA, Dunn JP, et al. Pars planitis: clinical features and class II HLA associations. Ophthalmology. 1999;106:594–599
  24. Tang WM, Pulido JS, Eckels DD, et al. The association of HLA-DR15 and intermediate uveitis. Am J Ophthalmol. 1997;123:70–75
  25. Malinowski SM, Pulido JS, Goeken NE, et al. The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis. Ophthalmology. 1993;100:1199–1205
  26. Association of birdshot retinochroidopathy and HLA-A29 antigen. Doc Ophthalmol. 1986;61:267–269
  27. Davis JL, Mittal KK, Freidlin V, et al. HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. Ophthalmology. 1990;97:1137–1142
  28. Shindo Y, Ohno S, Osui M, et al. Immunogenetic study of sympathetic ophthalmia. Tissue Antigens. 1997;49:111–115
  29. Monowarul Islam SM, Numaga J, Fujino Y, et al. HLA class II genes in Vogt-Koyanagi-Harada disease. Invest Ophthal Vis Sci. 1994;35:3890–3896
  30. Goldberg AC, Yamamoto JH, Chiarella JM, et al. HLA-DRB1*0405 is the predominant allele in Brazilian patients with Vogt-Koyanagi-Harada disease. Hum Immun. 1998;59:183–188
  31. Davis JL, Mittal KK, Freidlin V, et al. HLA associations and ancestry in Vogt-Koyanagi-Harada disease and sympathetic ophthalmia. Ophthalmology. 1990;97:1137–1142
  32. Arellanes-Garcia L, Bautista N, Mora P, et al. HLA-DR is strongly associated with Vogt-Koyanagi-Harada disease in Mexican Mestizo patients. Ocul Immunol Inflamm. 1998;6:93–100
  33. Weisz JM, Holland GN, Roer LN, et al. Association between Vogt-Koyanagi-Harada syndrome and HLA-DR1 and -DR4 in Hispanic patients living in southern California. Ophthalmology. 1995;102:1012–1015
  34. Zhao M, Jiang Y, Abrahams W. Association of HLA antigens with Vogt-Koyanagi-Harada syndrome in a Han Chinese population. Arch Ophthalmol. 1991;109:368–370
  35. Pivetti-Pezzi P, Accorinti M, Colabelli-Gisoldi RAM, Pirraglia MP. Vogt-Koyanagi-Harada disease and HLA type in Italian patients. Am J Ophthalmol. 1996;122:889–891
  36. Zhang XY, Wang XM, Hu TS. Profiling human leukocyte antigens in Vogt-Koyanagi-Harada syndrome. Am J Ophthalmol. 1992;113:567–572
  37. Mizuki N, Inoko H, Mizuki N, et al. Human leukocyte antigen serologic and DNA typing of Behçet's disease and its primary association with B51. Invest Ophthalmol Vis Sci. 1992;33:3332–3340
  38. Koumantaki Y, Stavropoulos C, Spyropoulou M, et al. HLA-B*5101 in Greek patients with Behçet's disease. Hum Immun. 1998;59:250–255
  39. Mizuki N, Ota M, Yabuki K, et al. Localization of the pathogenic gene of Behçet's disease by microsatellite analysis of three different populations. Invest Ophthal Vis Sci. 2000;41:3702–3708
  40. McCannel CA, Holland GN, Helm CJ, et al. Cause of uveitis in the general practice ophthalmology. Am J Ophthalmol. 1996;121:35–46
  41. Rodriguez A, Calonge M, Pedroza-Seres M, et al. Referral patterns of uveitis in a tertiary eye care center. Arch Ophthalmol. 1996;114:595–599
  42. Weiner A, Benezra D. Clinical patterns and associated conditions in chronic uveitis. Am J Ophthalmol. 1991;112:151–158
  43. Rembold CM, Watson D. Posttest probability calculation by weights: a simple form of Bayes' theorem. Ann Intern Med. 1988;108:115–120
  44. Rosenbaum JT, Wernick R. The utility of routine screening of patients with uveitis for systemic lupus erythematosus or tuberculosis. Arch Ophthalmol. 1990;108:1291–1293

PII: S0002-9394(09)00731-4

doi: 10.1016/j.ajo.2009.09.018

American Journal of Ophthalmology
Volume 149, Issue 2 , Pages 189-193.e2 , 1 February 2010

Article Tools