Retinal Thickness Analysis by Race, Gender, and Age Using Stratus OCT
Accepted 30 September 2009. published online 30 December 2009.
Purpose
To detect differences in retinal thickness among patients of different race, gender, and age using Stratus OCT.
Design
Cross-sectional study.
Methods
In a multicenter, university-based study, 126 patients with no history of ocular disease were enrolled (78 diabetics without retinopathy and 48 nondiabetics). Optical coherence tomography measurements were performed using Stratus OCT. Statistical comparisons of center point foveal thickness and mean foveal thickness were made using generalized estimating equations adjusting for diabetic status, race, age, and gender.
Results
The study population consisted of 36% male subjects, 39% Caucasian, 33% African-American, and 28% Hispanic. Mean foveal thickness was 191.6 ± 2.7 μm and 194.5 ± 2.7 μm for diabetics and nondiabetics, respectively (P = .49). Mean foveal thickness in male subjects was significantly larger than in female (201.8 ± 2.7 μm and 186.9 ± 2.6 μm, respectively; P < .001). Mean foveal thickness was 200.2 ± 2.7 μm for Caucasian, 181.0 ± 3.7 μm for African-American, and 194.7 ± 3.9 μm for Hispanic subjects. Mean foveal thickness was significantly less for African-American than Caucasian (P < .0001) or Hispanic subjects (P = .005). Center point foveal thickness and mean foveal thickness showed a significant increase with age.
Conclusions
There are statistically significant differences in retinal thickness between subjects of different race, gender, and age. When compared to Caucasian and Hispanic subjects, African-American race is a predictor of decreased mean foveal thickness; and male sex (regardless of race) is a significant predictor of increased mean foveal thickness. Mean foveal thickness is similar among diabetics and nondiabetics when data are controlled for age, race, and sex. These results suggest that studies comparing OCT measurements should carefully control for age-based, race-based, and gender-based variations in retinal thickness.
aWilmer Eye Institute and Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland
bDoheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
cDepartment of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California
dDepartment of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California
Inquiries to Quan Dong Nguyen, MD, MSc, Johns Hopkins Hospital, Wilmer Eye Institute, 600 North Wolfe St, Maumenee 745, Baltimore, MD 21287
ABSTRACT