Retinal Thickness Analysis by Race, Gender, and Age Using Stratus OCT

Kashani, Amir H.; Zimmer-Galler, Ingrid E.; Shah, Syed Mahmood; Dustin, Laurie; Do, Diana V.; Eliott, Dean; Haller, Julia A.; Nguyen, Quan Dong

doi:10.1016/j.ajo.2009.09.025

« Previous Next »American Journal of Ophthalmology
Volume 149, Issue 3 , Pages 496-502.e1, March 2010

Retinal Thickness Analysis by Race, Gender, and Age Using Stratus OCT

Amir H. Kashani
- Wilmer Eye Institute and Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland
- Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
- Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California
Ingrid E. Zimmer-Galler
- Wilmer Eye Institute and Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland
Syed Mahmood Shah
- Wilmer Eye Institute and Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland
Laurie Dustin
- Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
- Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, Los Angeles, California
Diana V. Do
- Wilmer Eye Institute and Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland
Dean Eliott
- Doheny Eye Institute, Keck School of Medicine of the University of Southern California, Los Angeles, California
- Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California
Julia A. Haller
- Wilmer Eye Institute and Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland
Quan Dong Nguyen
- Wilmer Eye Institute and Department of Ophthalmology, Johns Hopkins University, Baltimore, Maryland
- Inquiries to Quan Dong Nguyen, MD, MSc, Johns Hopkins Hospital, Wilmer Eye Institute, 600 North Wolfe St, Maumenee 745, Baltimore, MD 21287

Accepted 30 September 2009. published online 30 December 2009.

Purpose

To detect differences in retinal thickness among patients of different race, gender, and age using Stratus OCT.

Design

Cross-sectional study.

Methods

In a multicenter, university-based study, 126 patients with no history of ocular disease were enrolled (78 diabetics without retinopathy and 48 nondiabetics). Optical coherence tomography measurements were performed using Stratus OCT. Statistical comparisons of center point foveal thickness and mean foveal thickness were made using generalized estimating equations adjusting for diabetic status, race, age, and gender.

Results

The study population consisted of 36% male subjects, 39% Caucasian, 33% African-American, and 28% Hispanic. Mean foveal thickness was 191.6 ± 2.7 μm and 194.5 ± 2.7 μm for diabetics and nondiabetics, respectively (P = .49). Mean foveal thickness in male subjects was significantly larger than in female (201.8 ± 2.7 μm and 186.9 ± 2.6 μm, respectively; P < .001). Mean foveal thickness was 200.2 ± 2.7 μm for Caucasian, 181.0 ± 3.7 μm for African-American, and 194.7 ± 3.9 μm for Hispanic subjects. Mean foveal thickness was significantly less for African-American than Caucasian (P < .0001) or Hispanic subjects (P = .005). Center point foveal thickness and mean foveal thickness showed a significant increase with age.

Conclusions

There are statistically significant differences in retinal thickness between subjects of different race, gender, and age. When compared to Caucasian and Hispanic subjects, African-American race is a predictor of decreased mean foveal thickness; and male sex (regardless of race) is a significant predictor of increased mean foveal thickness. Mean foveal thickness is similar among diabetics and nondiabetics when data are controlled for age, race, and sex. These results suggest that studies comparing OCT measurements should carefully control for age-based, race-based, and gender-based variations in retinal thickness.