American Journal of Ophthalmology
Volume 149, Issue 3 , Pages 433-440.e1 , March 2010

Viral Retinitis After Intravitreal Triamcinolone Injection in Patients With Predisposing Medical Comorbidities

,Accepted 15 October 2009.

References 

  1. Wiegand TW, Young LH. Cytomegalovirus retinitis. Int Ophthalmol Clin. 2006;46:91–110
  2. Kuo IC, Kempen JH, Dunn JP, et al. Clinical characteristics and outcomes of cytomegalovirus retinitis in persons without human immunodeficiency virus infection. Am J Ophthalmol. 2004;138:338–346
  3. Crippa F, Corey L, Chuang EL, et al. Virological, clinical, and ophthalmologic features of cytomegalovirus retinitis after hematopoietic stem cell transplantation. Clin Infect Dis. 2001;32:214–219
  4. Benz MS, Glaser JS, Davis JL. Progressive outer retinal necrosis in immunocompetent patients treated initially for optic neuropathy with systemic corticosteroids. Am J Ophthalmol. 2003;135:551–553
  5. Browning DJ. Acute retinal necrosis following epidural steroid injections. Am J Ophthalmol. 2003;136:192–194
  6. Goldstein DA, Pyatetsky D. Necrotizing herpetic retinopathies. Focal Points: Clinical Modules for Ophthalmologists. 2008;26:1–16
  7. Freeman WR, Thomas EL, Rao NA, et al. Demonstration of herpes group virus in acute retinal necrosis syndrome. Am J Ophthalmol. 1986;102:701–709
  8. Saidel MA, Berreen J, Margolis TP. Cytomegalovirus retinitis after intravitreal triamcinolone in an immunocompetent patient. Am J Ophthalmol. 2005;140:1141–1143
  9. Delyfer MN, Rougier MB, Hubschman JP, et al. Cytomegalovirus retinitis following intravitreal injection of triamcinolone: report of two cases. Acta Ophthalmol Scand. 2007;85:681–683
  10. Ufret-Vincenty RL, Singh RP, Lowder CY, Kaiser PK. Cytomegalovirus retinitis after fluocinolone acetonide (Retisert™) implant. Am J Ophthalmol. 2007;143:334–335
  11. Aggermann T, Stolba U, Brunner S, Binder S. Endophthalmitis with retinal necrosis following intravitreal triamcinolone acetonide injection. Ophthalmologica. 2006;220:131–133
  12. Toh TY, Borthwick JH. Acute retinal necrosis post intravitreal injection of triamcinolone acetonide. In: Royal Australian and New Zealand College of Ophthalmologists; 2006;p. 380–382
  13. Park YS, Byeon SH. Cytomegalovirus retinitis after intravitreal triamcinolone injection in a patient with central retinal vein occlusion. Korean J Ophthalmol. 2008;22:143–144
  14. Sekiryu T, Tomohiro I, Kaneko H, Saito M. Cytomegalovirus retinitis after intravitreal triamcinolone acetonide in an immunocompetent patient. Jpn J Ophthalmol. 2008;52:414–416
  15. Jonas JB, Kreissig I, Sofker A, Degenring RF. Intravitreal injection of triamcinolone for the treatment of diffuse diabetic macular edema. Arch Ophthalmol. 2003;121:57–61
  16. Jonas JB, Kreissig I, Degenring RF. Intravitreal triamcinolone acetonide for pseudophakic cystoid macular edema. Am J Ophthalmol. 2003;136:384–386
  17. Antcliff RJ, Spalton DJ, Stanford MR, et al. Intravitreal triamcinolone for uveitis cystoid macular edema: an optical coherence tomography study. Ophthalmology. 2001;108:765–772
  18. Park CH, Jaffe GJ, Fekrat S. Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central retinal vein occlusion. Am J Ophthalmol. 2003;136:419–425
  19. Smithen LM, Ober MD, Maranan L, Spaide RF. Intravitreal triamcinolone acetonide and intraocular pressure. Am J Ophthalmol. 2004;138:740–743
  20. Diabetic Retinopathy Clinical Research Network. A randomized trial comparing intravitreal triamcinolone acetonide and focal/grid photocoagulation for diabetic macular edema. Ophthalmology. 2008;115:1447–1459
  21. Jabs DA, Van Natta ML, Kempen JH. Characteristics of patients with cytomegalovirus retinitis in the era of highly active antiretroviral therapy. Am J Ophthalmol. 2002;133:48–61
  22. Morrison VL, Kozak I, LaBree LD, et al. Intravitreal triamcinolone acetonide for the treatment of immune recovery uveitis macular edema. Ophthalmology. 2007;114:334–339
  23. Dalessandro L, Bottaro E. Reactivation of CMV retinitis after treatment with subtenon's corticosteroids for immune recovery uveitis in a patient with AIDS. Scand J Infect Dis. 2002;34:780–782
  24. Song MK, Schrier RD, Smith IL, Plummer DJ, Freeman WR. Paradoxical activity of CMV retinitis in patients receiving highly active antiretroviral therapy. Retina. 2002;22:262–267
  25. Jacobson MA, Zegans M, Pavan PR, et al. Cytomegalovirus retinitis after initiation of highly active antiretroviral therapy. Lancet. 1997;349:1443–1445
  26. Petit N, Zandotti C, Riss JM, et al. Relapse of CMV retinitis in an AIDS patient with high CD4 counts. J Antimicrob Chemother. 1998;41:666–667
  27. Angus BJ, et al. HIV-associated CMV retinitis occurring in the setting of a high CD4 count: what about AIDS definitions?. Int J STD AIDS. 1994;5:71–72
  28. Frame RD, Hutchins RK, Skahan KJ, et al. Progression of cytomegaloviral retinitis in a patient responding to highly active antiretroviral therapy. Invest Ophthalmol Vis Sci. 1999;40:S873
  29. Moshfeghi DM, Kaiser PK, Scott IU, et al. Acute endophthalmitis following intravitreal triamcinolone acetonide injection. Am J Ophthalmol. 2003;136:791–796
  30. Fintak DR, Shah GK, Blinder KJ, et al. Incidence of endophthalmitis related to intravitreal injection of bevacizumab and ranibizumab. Retina. 2008;28:1395–1399
  31. Morrison VL, Koh HJ, Cheng L, et al. Intravitreal toxicity of the Kenalog vehicle (benzyl alcohol) in rabbits. Retina. 2006;26:339–344
  32. Tammewar AM, Cheng L, Kayikcioglu OR, et al. Comparison of 4 mg versus 20 mg intravitreal triamcinolone acetonide injections. Br J Ophthalmol. 2008;92:810–813
  33. Jonas JB. Intraocular availability of triamcinolone acetonide after intravitreal injection. Am J Ophthalmol. 2004;137:560–562
  34. Jonas JB. Concentration of intravitreally injected triamcinolone acetonide in intraocular silicone oil. Br J Ophthalmol. 2002;86:1450–1451
  35. Kosobucki BR, Freeman WR, Cheng L. Photographic estimation of the duration of high dose intravitreal triamcinolone in the vitrectomised eye. Br J Ophthalmol. 2006;90:705–708
  36. Beer PM, Bakri SJ, Singh RJ, et al. Intraocular concentration and pharmacokinetics of triamcinolone acetonide after a single intravitreal injection. Ophthalmology. 2003;110:681–686

PII: S0002-9394(09)00802-2

doi: 10.1016/j.ajo.2009.10.019

American Journal of Ophthalmology
Volume 149, Issue 3 , Pages 433-440.e1 , March 2010