American Journal of Ophthalmology
Volume 149, Issue 4 , Pages 585-593 , April 2010

Long-term Results of Riboflavin Ultraviolet A Corneal Collagen Cross-linking for Keratoconus in Italy: The Siena Eye Cross Study

  • Aldo Caporossi

      Affiliations

    • Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    • ,
  • Cosimo Mazzotta

      Affiliations

    • Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    • Corresponding Author InformationInquiries to Cosimo Mazzotta, Dipartimento di Scienze Oftalmologiche e Neurochirurgiche, Policlinico Santa Maria delle Scotte, Viale Bracci 8, 53100 Siena, Italy
    • ,
  • Stefano Baiocchi

      Affiliations

    • Department of Ophthalmology and Neurosurgery, Santa Maria delle Scotte Hospital, Siena University, Siena, Italy
    • ,
  • Tomaso Caporossi

      Affiliations

    • Department of Ophthalmology, Agostino Gemelli Hospital, Rome Catholic University, Rome, Italy

,Accepted 31 October 2009.

References 

  1. Scroggs MW, Proia AD. Histopathological variation in keratoconus. Cornea. 1992;11:553–559
  2. Smolek MK, Beekhuis WH. Collagen fibril orientation in the human corneal stroma and its implications in keratoconus. Invest Ophthalmol Vis Sci. 1997;38:1289–1290
  3. Radner W, Zehemayer M, Skorpik C, Mallinger R. Altered organization of collagen in apex of keratoconus corneas. Ophthalmic Res. 1998;30:327–332
  4. Andreasson TT, Simonsen AH, Oxlund H. Biomechanical properties of keratoconus and normal corneas. Exp Eye Res. 1980;31:435–441
  5. Spoerl E, Huhle M, Seiler T. Induction of cross links in corneal tissue. Exp Eye Res. 1998;66:97–103
  6. Wollensak G, Spoerl E, Seiler T. Riboflavin/ultraviolet-A-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol. 2003;135:620–627
  7. Spoerl E, Wollensak G, Seiler T. Increased resistance of crosslinked cornea against enzymatic digestion. Curr Eye Res. 2004;29:35–40
  8. Spörl E, Raiskup-Wolf F, Pillunat LE. Biophysical principles of collagen cross-linking. Klin Monatsbl Augenheilkd. 2008;225:131–137
  9. Caporossi A, Baiocchi S, Mazzotta C, et al. Parasurgical therapy for keratoconus by riboflavin-ultraviolet type A induced cross-linking of corneal collagen: preliminary refractive results in an Italian study. J Cataract Refract Surg. 2006;32:837–845
  10. Mazzotta C, Traversi C, Baiocchi S, et al. Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol. 2008;146:527–533
  11. Raiskup-Wolf F, Hoyer A, Spoerl E, Pillunat LE. Collagen crosslinking with riboflavin and ultraviolet-A light in keratoconus: long-term results. J Cataract Refract Surg. 2008;34:796–801
  12. Spoerl E, Mrochen M, Sliney D, Trokel S, Seiler T. Safety of UVA-riboflavin cross-linking of the cornea. Cornea. 2007;26:385–389
  13. Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, et al. Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by Heidelberg Retinal Tomograph II in vivo confocal microscopy in humans. Cornea. 2007;26:390–397
  14. Mazzotta C, Traversi C, Baiocchi S, Sergio P, Caporossi T, Caporossi A. Conservative treatment of keratoconus by riboflavin-uva-induced cross-linking of corneal collagen: qualitative investigation. Eur J Ophthalmol. 2006;16:530–535
  15. Serway RA. Physics for Scientist and Engineers. In: Philadelphia: Saunders College Publishing; 1992;p. 946–948
  16. Romppainen T, Bachmann LM, Kaufmann C, Kniestedt C, Mrochen M, Thiel MA. Effect of riboflavin UVA induced collagen cross-linking on intraocular pressure measurement. Invest Ophthalmol Vis Sci. 2007;48:5494–5498
  17. Mazzotta C, Balestrazzi A, Baiocchi S, Traversi C, Caporossi A. Stromal haze after combined riboflavin-UVA corneal collagen cross-linking in keratoconus: in vivo confocal microscopic evaluation. Clin Experiment Ophthalmol. 2007;35:580–582
  18. Seiler T, Hafezi F. Corneal cross-linking-induced stromal demarcation line. Cornea. 2006;25:1057–1059
  19. Bourne WM, Nelson LR, Hodge DO. Central corneal endothelial cell changes over a ten-year period. Invest Ophthalmol Vis Sci. 1997;38:779–782
  20. Bourne WM, Hodge DO, Nelson LR. Corneal endothelium five years after transplantation. Am J Ophthalmol. 1994;118:185–196
  21. Bourne WM, Nelson LR, Hodge DO. Continued endothelial cell loss ten years after lens implantation. Ophthalmology. 1994;101:1014–1022discussion 1022–1023
  22. Baiocchi S, Mazzotta C, Cerretani D, Caporossi T, Caporossi A. Corneal cross-linking: riboflavin concentration in corneal stroma exposed with and without epithelium. J Cataract Refract Surg. 2009;35:893–899
  23. Chan CC, Sharma M, Wachler BS. Effect of inferior-segment Intacs with and without C3-R on keratoconus. J Cataract Refract Surg. 2007;33:75–80
  24. Wollensak G, Redl B. Gel electrophoretic analysis of corneal collagen after photodynamic cross-linking treatment. Cornea. 2008;27:353–356
  25. Reeves SW, Stinnett S, Adelman RA, Afshari NA. Risk factors for progression to penetrating keratoplasty in patients with keratoconus. Am J Ophthalmol. 2005;140:607–611

PII: S0002-9394(09)00808-3

doi: 10.1016/j.ajo.2009.10.021

American Journal of Ophthalmology
Volume 149, Issue 4 , Pages 585-593 , April 2010

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