American Journal of Ophthalmology
Volume 149, Issue 4 , Pages 562-570 , April 2010

Ocular Signs Predictive of Tubercular Uveitis

  • Amod Gupta

      Affiliations

    • Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    • Corresponding Author InformationInquiries to Amod Gupta, Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India
    • ,
  • Reema Bansal

      Affiliations

    • Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    • ,
  • Vishali Gupta

      Affiliations

    • Department of Ophthalmology, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    • ,
  • Aman Sharma

      Affiliations

    • Department of Internal Medicine, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India
    • ,
  • Pradeep Bambery

      Affiliations

    • Department of Internal Medicine, Advanced Eye Center, Post Graduate Institute of Medical Education and Research, Chandigarh, India

,Accepted 17 November 2009.

References 

  1. Gupta V, Gupta A, Rao NA. Intraocular tuberculosis—an update. Surv Ophthalmol 07;52:561–587.
  2. Bansal R, Gupta A, Gupta V, et al. Role of anti-tubercular therapy in uveitis with latent/manifest tuberculosis. Am J Ophthalmol. 2008;146:772–779
  3. Kurup SK, Buggage RR, Clarke GL, et al. Gamma interferon assay as an alternative to PPD skin testing in selected patients with granulomatous intraocular inflammatory disease. Can J Ophthalmol. 2006;41:737–740
  4. Itty S, Bakri SJ, Pulido JS, et al. Initial results of quantiFERON-TB Gold testing in patients with uveitis. Eye. 2009;23:904–909
  5. Mackensen F, Becker MD, Wiehler U, Max R, et al. QuantiFERON-TB Gold- a new test strengthening long-suspected tuberculous involvement in serpiginous-like choroiditis. Am J Ophthalmol. 2008;146:761–766
  6. Arora SK, Gupta V, Gupta A, et al. Diagnostic efficacy of polymerase chain reaction in granulomatous uveitis. Tuber Lung Dis. 1999;79:229–233
  7. American Thoracic Society. Diagnostic standards and classification of tuberculosis and other mycobacterial diseases (14th edition). Am Rev Respir Dis. 1981;123:343
  8. Helm CJ, Holland GN. Ocular tuberculosis. Surv Ophthalmol. 1993;38:229–256
  9. Barondes MJ, Sponsel WE, Stevens TS, Plotnik RD. Tuberculous choroiditis diagnosed by chorioretinal endobiopsy. Am J Ophthalmol. 1991;112:460–461
  10. Biswas J, Madhavan HN, Gopal L, Badrinath SS. Intraocular tuberculosis: clinicopathologic study of five cases. Retina. 1995;15:461–468
  11. Raina UK, Tuli D, Arora R, et al. Tuberculous endophthalmitis simulating retinoblastoma. Am J Ophthalmol. 2000;130:843–845
  12. Sen S, Kashyap S, Singh UB, et al. Intraocular tuberculosis mimicking retinoblastoma: a case report. Diagn Cytopathol. 2003;28:107–109
  13. Rao NA, Saraswathy S, Smith RE. Tuberculous uveitis: distribution of Mycobacterium tuberculosis in the retinal pigment epithelium. Arch Ophthalmol. 2006;124:1777–1779
  14. Rosen PH, Spalton DJ, Graham EM. Intraocular tuberculosis. Eye. 1990;4:486–492
  15. Morimura Y, Okada AA, Kawahara S, et al. Tuberculin skin testing in uveitis patients and treatment of presumed intraocular tuberculosis in Japan. Ophthalmology. 2002;109:851–857
  16. Gupta A, Gupta V. Tubercular posterior uveitis. Int Ophthalmol Clin. 2005;45:71–88
  17. Varma D, Anand S, Reddy AR, et al. Tuberculosis: an under-diagnosed aetiological agent in uveitis with an effective treatment. Eye. 2006;20:1068–1073
  18. Mehta S. Ocular lesions in acute disseminated tuberculosis. Ocul Immunol Inflamm. 2004;12:311–315
  19. Biswas J, Shome D. Choroidal tubercles in disseminated tuberculosis diagnosed by the polymerase chain reaction of aqueous humor (A case report and review of the literature). Ocul Immunol Inflamm. 2002;10:293–298
  20. Mehta S, Chauhan V, Hastak S, et al. Choroidal tubercles in neurotuberculosis (Prevalence and significance). Ocul Immunol Inflamm. 2006;14:341–345
  21. Gupta V, Gupta A, Sachdev N, et al. Successful management of tubercular subretinal granulomas. Ocul Immunol Inflamm. 2006;14:35–40
  22. Parikh R, Parikh S, Arun E, Thomas R. Likelihood ratios: clinical application in day-to-day practice. Ind J Ophthalmol. 2009;57:217–221
  23. Moons KG, van Es GA, Deckers JW, et al. Limitations of sensitivity, specificity, likelihood ratio, and Bayes' theorem in assessing diagnostic probabilities (A clinical example). Epidemiology. 1997;8:12–17
  24. Brenner H, Gefeller O. Variation of sensitivity, specificity, likelihood ratios, and predictive values with disease prevalence. Stat Med. 1997;16:981–991
  25. Sackett DL, Haynes RB, Guyatt GH, Tugwell P. Clinical Epidemiology. In: A Basic Science for Clinical Medicine. New York: Little, Brown; 1991;p. 109–167
  26. Samson MC, Foster CS. Tuberculosis. In:  Foster CS,  Vitale AT editor. Diagnosis and Treatment of Uveitis. Philadelphia: WB Saunders Company; 2002;p. 264–272
  27. Rathinam SR, Khairallah M, Hmidi K. Anterior granulomatous uveitis. In:  Gupta A,  Gupta V,  Herbort CP,  Khairallah M editor. Uveitis Text and Imaging. New Delhi: Jaypee Brothers; 2009;p. 335–347
  28. Gupta A, Gupta V, Bansal R, et al. Ocular tuberculosis in endemic areas. In:  Gupta A,  Gupta V,  Herbort CP,  Khairallah M editor. Uveitis Text and Imaging. New Delhi: Jaypee Brothers; 2009;p. 563–577
  29. Tugal-Tutkun I, Aydin-Akova Y, Güney-Tefekli E, Aynaci-Kahraman B. Referral patterns, demographic and clinical features, and visual prognosis of Turkish patients with sarcoid uveitis. Ocul Immunol Inflamm. 2007;15:337–343
  30. Moorthy RS, Inomata H, Rao NA. Vogt-Koyanagi-Harada syndrome. Surv Ophthalmol. 1995;39:265–292
  31. Gupta A, Gupta V, Arora S, et al. PCR-positive tubercular retinal vasculitis: clinical characteristics and management. Retina. 2001;21:435–444
  32. Hoh HB, Kong VY, Jaais F. Tuberculous retinal vasculitis. Med J Malaysia. 1998;53:288–289
  33. Reny JL, Challe G, Geisert P, et al. Tuberculosis-related retinal vasculitis in an immunocompetent patient. Clin Infect Dis. 1996;22:873–874
  34. Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, et al. Uveitis in Behcet disease: an analysis of 880 patients. Am J Ophthalmol. 2004;138:373–380
  35. Obenauf CD, Shaw HE, Sydnor CF, Klintworth GK. Sarcoidosis and its ophthalmic manifestations. Am J Ophthalmol. 1978;86:648–655
  36. Gupta V, Gupta A, Arora S, et al. Presumed tubercular serpiginouslike choroiditis: clinical presentations and management. Ophthalmology. 2003;110:1744–1749
  37. Ang M, Htoon HMChee Soon-Phaik. Diagnosis of tubercular uveitis: clinical application of an interferon-gamma release assay. Ophthalmology. 2009;116:1391–1396

PII: S0002-9394(09)00883-6

doi: 10.1016/j.ajo.2009.11.020

American Journal of Ophthalmology
Volume 149, Issue 4 , Pages 562-570 , April 2010

Article Tools

* Image Usage & Resolution