American Journal of Ophthalmology
Volume 149, Issue 5 , Pages 839-851.e1 , May 2010

Topical Mecamylamine for Diabetic Macular Edema

  • Peter A. Campochiaro

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • Corresponding Author InformationInquiries to Peter A. Campochiaro, Johns Hopkins University School of Medicine, 600 North Wolfe Street, Maumenee 719, Baltimore, MD 21287-9277
    • ,
  • Syed Mahmood Shah

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Gulnar Hafiz

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Jeffery S. Heier

      Affiliations

    • Ophthalmic Consultants of Boston, Boston, Massachusetts
    • ,
  • Eugene S. Lit

      Affiliations

    • East Bay Retina Consultants, Boston, Massachusetts
    • ,
  • Ingrid Zimmer-Galler

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Roomasa Channa

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Quan Dong Nguyen

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Beena Syed

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Diana V. Do

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • Lili Lu

      Affiliations

    • Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland
    • ,
  • James Monk

      Affiliations

    • CoMentis, Inc, South San Francisco, California
    • ,
  • John P. Cooke

      Affiliations

    • Division of Cardiovascular Medicine, Stanford University, Palo Alto, California
    • ,
  • M. Ken Kengatharan

      Affiliations

    • CoMentis, Inc, South San Francisco, California
    • ,
  • Henry H. Hsu

      Affiliations

    • CoMentis, Inc, South San Francisco, California

,Accepted 1 December 2009.

References 

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  17. Rose JE, Behm FM, Westman EC. Nicotine-mecamylamine treatment for smoking cessation: the role of pre-cessation therapy. Exp Clin Psychopharmaocol. 1998;6:331–343
  18. Early Treatment Diabetic Retinopathy Study Research Group. Photocoagulation for diabetic macular edema (Early Treatment Diabetic Retinopathy Study report number 1). Arch Ophthalmol. 1985;103:1796–1806
  19. Chan A, Duker JS, Ko TH, Fujimoto JG, Schuman JS. Normal macular thickness measurements in healthy eyes using Stratus optical coherence tomography. Arch Ophthalmol. 2006;124:193–198
  20. Wu JCF, Chruscinski A, De Jesus Perez VA, et al. Cholinergic modulation of angiogenesis: role of the alpha 7 nictotinic acetylcholine receptor. J Cell Biochem. 2009;108:433–446
  21. Nguyen QD, Tatlipinar S, Shah SM, et al. Vascular endothelial growth factor is a critical stimulus for diabetic macular edema. Am J Ophthalmol. 2006;142:961–969
  22. Nguyen QD, Shah SM, Heier JS, et al. Primary end point (six months) results of the Ranibizumab for Edema of the Macula in Diabetes (READ-2) Study. Ophthalmology. 2009;116:2175–2181

PII: S0002-9394(09)00908-8

doi: 10.1016/j.ajo.2009.12.005

American Journal of Ophthalmology
Volume 149, Issue 5 , Pages 839-851.e1 , May 2010

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