American Journal of Ophthalmology
Volume 149, Issue 5 , Pages 777-784 , May 2010

Efficacy and Tolerability of Preservative-Free and Preserved Diclofenac and Preserved Ketorolac Eyedrops After Cataract Surgery

  • Saskia M. Maca

      Affiliations

    • Department of Ophthalmology & Optometry, Medical University Vienna, Vienna, Austria
    • ,
  • Michael Amon

      Affiliations

    • Department of Ophthalmology & Optometry, Medical University Vienna, Vienna, Austria
    • ,
  • Oliver Findl

      Affiliations

    • Moorfields Eye Hospital, NHS Foundation Trust, London, United Kingdom
    • ,
  • Gunal Kahraman

      Affiliations

    • Department of Ophthalmology & Optometry, Medical University Vienna, Vienna, Austria
    • ,
  • Talin Barisani-Asenbauer

      Affiliations

    • Department of Ophthalmology & Optometry, Medical University Vienna, Vienna, Austria
    • Corresponding Author InformationInquiries to Talin Barisani-Asenbauer, Uveitis Unit, Department of Ophthalmology & Optometry, Medical University Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria

,Accepted 4 December 2009.

References 

  1. Flach AJ, Dolan BJ, Donahue ME, Faktorovich EG, Gonzalez GA. Comparative effects of ketorolac 0.5% or diclofenac 0.1% ophthalmic solutions on inflammation after cataract surgery. Ophthalmology. 1998;105:1775–1779
  2. Rossetti L, Chaudhuri J, Dickersin K. Medical prophylaxis and treatment of cystoid macular edema after cataract surgery (The results of a meta-analysis). Ophthalmology. 1998;105:397–405
  3. Sivaprasad S, Bunce C, Patel N. Non-steroidal anti-inflammatory agents for treating cystoid macular oedema following cataract surgery. Cochrane Database Syst Rev. 2005;CD004239
  4. Rho DS. Treatment of acute pseudophakic cystoid macular edema: diclofenac versus ketorolac. J Cataract Refract Surg. 2003;29:2378–2384
  5. Flach AJ. Topical nonsteroidal antiinflammatory drugs in ophthalmology. Int Ophthalmol Clin. 2002;42:1–11
  6. Gaynes BI, Fiscella R. Topical nonsteroidal anti-inflammatory drugs for ophthalmic use: a safety review. Drug Saf. 2002;25:233–250
  7. Miyake K, Ibaraki N, Goto Y, et al. ESCRS Binkhorst lecture 2002: pseudophakic preservative maculopathy. J Cataract Refract Surg. 2003;29:1800–1810
  8. el-Harazi SM, Feldman RM, Chuang AZ, Ruiz RS, Villanueva G. Reproducibility of the laser flare meter and laser cell counter in assessing anterior chamber inflammation following cataract surgery. Ophthalmic Surg Lasers. 1998;29:380–384
  9. Shah SM, Spalton DJ. Changes in anterior chamber flare and cells following cataract surgery. Br J Ophthalmol. 1994;78:91–94
  10. el-Maghraby A, Marzouki A, Matheen TM, Souchek J, Van der Karr M. Reproducibility and validity of laser flare/cell meter measurements of intraocular inflammation. J Cataract Refract Surg. 1993;19:52–55
  11. Ladas JG, Wheeler NC, Morhun PJ, Rimmer SO, Holland GN. Laser flare-cell photometry: methodology and clinical applications. Surv Ophthalmol. 2005;50:27–47
  12. Petternel V, Findl O, Kruger A, Schauersberger J, Amon M. Effect of tropicamide on aqueous flare before and after cataract surgery. J Cataract Refract Surg. 2000;26:382–385
  13. Maca SM, Garhofer G, Kiss C, Barisani-Asenbauer T. Screening for cystoid macular oedema in children with uveitis using the retinal thickness analyser. Acta Ophthalmol. 2008;86:292–296
  14. Polito A, Shah SM, Haller JA, et al. Comparison between retinal thickness analyzer and optical coherence tomography for assessment of foveal thickness in eyes with macular disease. Am J Ophthalmol. 2002;134:240–251
  15. Geisser S, Greenhouse S. An extension of box's results on the use of the F-distribution in multivariate analysis. Annals of Mathematical Statistics. 1958;29:885–891
  16. Friedman M. The use of ranks to avoid the assumption of normality implicit in the analysis of variance. J Amer Stat Assoc. 1937;32:675–701
  17. In:  Schaich E,  Hamerle A editor. Verteilungsfreie statistische Prüfverfahren. Berlin: Springer; 1984;
  18. Schalnus R. Topical nonsteroidal anti-inflammatory therapy in ophthalmology. Ophthalmologica. 2003;217:89–98
  19. Waterbury LD, Flach AJ. Comparison of ketorolac tromethamine, diclofenac sodium, and loteprednol etabonate in an animal model of ocular inflammation. J Ocul Pharmacol Ther. 2006;22:155–159
  20. Kraff MC, Martin RG, Neumann AC, Weinstein AJ. Efficacy of diclofenac sodium ophthalmic solution versus placebo in reducing inflammation following cataract extraction and posterior chamber lens implantation. J Cataract Refract Surg. 1994;20:138–144
  21. Solomon KD, Cheetham JK, DeGryse R, Brint SF, Rosenthal A. Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery. Ophthalmology. 2001;108:331–337
  22. el-Harazi SM, Ruiz RS, Feldman RM, Villanueva G, Chuang AZ. A randomized double-masked trial comparing ketorolac tromethamine 0.5%, diclofenac sodium 0.1%, and prednisolone acetate 1% in reducing post-phacoemulsification flare and cells. Ophthalmic Surg Lasers. 1998;29:539–544
  23. Yavas GF, Ozturk F, Kusbeci T. Preoperative topical indomethacin to prevent pseudophakic cystoid macular edema. J Cataract Refract Surg. 2007;33:804–807
  24. Heier JS, Topping TM, Baumann W, Dirks MS, Chern S. Ketorolac versus prednisolone versus combination therapy in the treatment of acute pseudophakic cystoid macular edema. Ophthalmology. 2000;107:2034–2038discussion 2039
  25. Liu DTL, Lee VYW, Lam DSC, Chan W-M. Retinal thickness measurement after phacoemulsification. J Cataract Refract Surg. 2005;31:1269–1270
  26. Asrani S, Zou S, d'Anna S, Vitale S, Zeimer R. Noninvasive mapping of the normal retinal thickness at the posterior pole. Ophthalmology. 1999;106:269–273
  27. Konno S, Akiba J, Yoshida A. Retinal thickness measurements with optical coherence tomography and the scanning retinal thickness analyzer. Retina. 2001;21:57–61
  28. Neubauer AS, Priglinger S, Ullrich S, et al. Comparison of foveal thickness measured with the retinal thickness analyzer and optical coherence tomography. Retina. 2001;21:596–601
  29. Woods CA, Cumming B. The impact of test medium on use of visual analogue scales. Eye Contact Lens. 2009;35:6–10
  30. Chiambaretta F, Creuzot-Garcher C, Pilon F, et al. Ocular tolerance of a new formulation of nonpreserved diclofenac. J Fr Ophtalmol. 2004;27:739–744
  31. Bodaghi B, Weber ME, Arnoux YV, Jaulerry SD, Le Hoang P, Colin J. Comparison of the efficacy and safety of two formulations of diclofenac sodium 0.1% eyedrops in controlling postoperative inflammation after cataract surgery. Eur J Ophthalmol. 2005;15:702–711
  32. Baudouin C, de Lunardo C. Short-term comparative study of topical 2% carteolol with and without benzalkonium chloride in healthy volunteers. Br J Ophthalmol. 1998;82:39–42

PII: S0002-9394(09)00913-1

doi: 10.1016/j.ajo.2009.12.010

American Journal of Ophthalmology
Volume 149, Issue 5 , Pages 777-784 , May 2010

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