American Journal of Ophthalmology
Volume 149, Issue 5 , Pages 741-751 , May 2010

Four-Year Incidence and Progression of Age-Related Macular Degeneration: The Los Angeles Latino Eye Study

  • Rohit Varma

      Affiliations

    • Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
    • Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
    • Corresponding Author InformationInquiries to Rohit Varma, Doheny Eye Institute, Suite 4900, 1450 San Pablo St, Los Angeles, CA 90033
    • ,
  • Athena W.P. Foong

      Affiliations

    • Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
    • ,
  • Mei-Ying Lai

      Affiliations

    • Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
    • ,
  • Farzana Choudhury

      Affiliations

    • Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
    • ,
  • Ronald Klein

      Affiliations

    • Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, Wisconsin
    • ,
  • Stanley P. Azen

      Affiliations

    • Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California
    • Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California
    • ,
  • Los Angeles Latino Eye Study Group

,Accepted 5 January 2010.

References 

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  3. Varma R, Wu J, Chong K, Azen SP, Hays RD. Impact of severity and bilaterality of visual impairment on health-related quality of life. Ophthalmology. 2006;113:1846–1853
  4. Klein R, Klein BE, Jensen SC, Meuer SM. The five-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study. Ophthalmology. 1997;104:7–21
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  7. Klein R, Klein BE, Linton KL. Prevalence of age-related maculopathy (The Beaver Dam Eye Study). Ophthalmology. 1992;99:933–943
  8. Mitchell P, Smith W, Attebo K, Wang JJ. Prevalence of age-related maculopathy in Australia (The Blue Mountains Eye Study). Ophthalmology. 1995;102:1450–1460
  9. Varma R, Fraser-Bell S, Tan S, Klein R, Azen SP. Prevalence of age-related macular degeneration in Latinos: the Los Angeles Latino Eye Study. Ophthalmology. 2004;111:1288–1297
  10. Shtir CJ, Marjoram P, Azen S, et al. Variation in genetic admixture and population structure among Latinos: the Los Angeles Latino Eye Study (LALES). BMC Genet. 2009;10:71
  11. Friedman E. The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration. Am J Ophthalmol. 2000;130:658–663
  12. Varma R, Paz SH, Azen SP, et al. The Los Angeles Latino Eye Study: design, methods, and baseline data. Ophthalmology. 2004;111:1121–1131
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  15. Buch H, Nielsen NV, Vinding T, Jensen GB, Prause JU, la Cour M. 14-year incidence, progression, and visual morbidity of age-related maculopathy: the Copenhagen City Eye Study. Ophthalmology. 2005;112:787–798
  16. Mukesh BN, Dimitrov PN, Leikin S, et al. Five-year incidence of age-related maculopathy: the Visual Impairment Project. Ophthalmology. 2004;111:1176–1182
  17. Tedeschi-Blok N, Buckley J, Varma R, Triche TJ, Hinton DR. Population-based study of early age-related macular degeneration: role of the complement factor H Y402H polymorphism in bilateral but not unilateral disease. Ophthalmology. 2007;114:99–103
  18. Schachat AP, Hyman L, Leske MC, Connell AM, Wu SY. Features of age-related macular degeneration in a black population (The Barbados Eye Study Group). Arch Ophthalmol. 1995;113:728–735
  19. Klaver CC, Assink JJ, van Leeuwen R, et al. Incidence and progression rates of age-related maculopathy: the Rotterdam Study. Invest Ophthalmol Vis Sci. 2001;42:2237–2241
  20. van Leeuwen R, Klaver CC, Vingerling JR, Hofman A, de Jong PT. The risk and natural course of age-related maculopathy: follow-up at 6 1/2 years in the Rotterdam study. Arch Ophthalmol. 2003;121:519–526
  21. Gudnadottir GS, Magnusson KP, Stefansson E, Jonasson F, Helgadottir G, Sigurdsson H. The time pattern of bilateral exudative age-related macular degeneration. Acta Ophthalmol Scand. 2005;83:333–336
  22. Wong TY, Chakravarthy U, Klein R, et al. The natural history and prognosis of neovascular age-related macular degeneration: a systematic review of the literature and meta-analysis. Ophthalmology. 2008;115:116–126
  23. Cahill MT, Banks AD, Stinnett SS, Toth CA. Vision-related quality of life in patients with bilateral severe age-related macular degeneration. Ophthalmology. 2005;112:152–158
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PII: S0002-9394(10)00025-5

doi: 10.1016/j.ajo.2010.01.009

American Journal of Ophthalmology
Volume 149, Issue 5 , Pages 741-751 , May 2010

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