American Journal of Ophthalmology
Volume 125, Issue 6 , Pages 844-851 , June 1998

Gelatinase B in proliferative vitreoretinal disorders

  • Ahmed M. Abu El-Asrar, MD

      Affiliations

    • Department of Ophthalmology, College of Medicine, King Saud University, Riyadh, Saudi Arabia (Dr Abu El-Asrar)
    • Corresponding Author InformationCorrespondence to Ahmed M. Abu El-Asrar, MD, Department of Ophthalmology, King Abdulaziz University Hospital, Airport Rd, PO Box 245, Riyadh 11411, Saudi Arabia; fax: 966-1-477-5741
  • ,
  • Lieve Dralands, MD

      Affiliations

    • Department of Ophthalmology Leuven, Belgium (Drs Dralands, Veckeneer, and Missotten)
  • ,
  • Marc Veckeneer, MD

      Affiliations

    • Department of Ophthalmology Leuven, Belgium (Drs Dralands, Veckeneer, and Missotten)
  • ,
  • Karel Geboes, MD

      Affiliations

    • Laboratory of Histochemistry and Cytochemistry Leuven, Belgium (Dr Geboes), University Hospital St Rafael, Leuven, Belgium
  • ,
  • Luc Missotten, MD

      Affiliations

    • Department of Ophthalmology Leuven, Belgium (Drs Dralands, Veckeneer, and Missotten)
  • ,
  • Ilse Van Aelst

      Affiliations

    • Rega Institute for Medical Research, Laboratory of Molecular Immunology (Ms Van Aelst and Dr Opdenakker), University of Leuven, Leuven, Belgium
  • ,
  • Ghislain Opdenakker, MD, PhD

      Affiliations

    • Rega Institute for Medical Research, Laboratory of Molecular Immunology (Ms Van Aelst and Dr Opdenakker), University of Leuven, Leuven, Belgium

,Accepted 23 September 1997.

References 

  1. Baudouin C, Fredj-Reygrobellet D, Gordon WC, et al.  Immunohistologic study of epiretinal membranes in proliferative vitreoretinopathy. Am J Ophthalmol. 1990;110:593–598
  2. Baudouin C, Gordon WC, Fredj-Reygrobellet D, et al.  Class II antigen expression in diabetic preretinal membranes. Am J Ophthalmol. 1990;109:70–74
  3. Esser P, Heimann K, Wiedemann P. Macrophages in proliferative vitreoretinopathy and proliferative diabetic retinopathy (differentiation and subpopulations). Br J Ophthalmol. 1993;77:731–733
  4. Tang S, Scheiffarth OF, Thurau SR, Wildner G. Cells of the immune system and their cytokines in epiretinal membranes and in the vitreous of patients with proliferative diabetic retinopathy. Ophthalmic Res. 1993;25:177–185
  5. Tang S, Le-Ruppert KC. Activated T lymphocytes in epiretinal membranes from eyes of patients with proliferative diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 1995;233:21–25
  6. Heidenkummer HP, Kampik A. Intercellular adhesion molecule-1 (ICAM-1) and leukocyte function-associated antigen-1 (LFA-1) expression in human epiretinal membranes. Graefes Arch Clin Exp Ophthalmol. 1992;230:483–487
  7. Limb GA, Chignell AH, Green W, Le Roy F, Dumonde DC. Distribution of TNF-α and its reactive vascular adhesion molecules in fibrovascular membranes of proliferative diabetic retinopathy. Br J Ophthalmol. 1996;80:168–173
  8. Kampik A, Kenyon KR, Michels RG, Green WR, de la Cruz ZC. Epiretinal and vitreous membranes (comparative study of 56 cases). Arch Ophthalmol. 1981;99:1445–1454
  9. Limb GA, Earley O, Jones SE, Le Roy F, Chignell AH, Dumonde DC. Expression of mRNA coding for TNF-α, IL-1β and IL-6 by cells infiltrating retinal membranes. Graefes Arch Clin Exp Ophthalmol. 1994;232:646–651
  10. Limb GA, Earley AO, Green W, Chignell AH, Dumonde DC. Distribution of cytokine proteins within epiretinal membranes in proliferative vitreoretinopathy. Curr Eye Res. 1994;13:791–798
  11. Limb GA, Little BC, Meager A, et al.  Cytokines in proliferative vitreoretinopathy. Eye. 1991;5:686–693
  12. Abu El-Asrar AM, Maimone D, Morse PH, Gregory S, Reder AT. Cytokines in the vitreous of patients with proliferative diabetic retinopathy. Am J Ophthalmol. 1992;114:731–736
  13. Woessner JF. Matrix metalloproteinases and their inhibitors in connective tissue remodelling. FASEB J. 1991;5:2145–2154
  14. Matrisian LM. The matrix-degrading metalloproteinases. Bioassays. 1992;14:455–463
  15. Opdenakker G, Van Damme J. Cytokines and proteases in invasive processes (molecular similarities between inflammation and Cancer). Cytokine. 1992;4:251–258
  16. Opdenakker G, Van Damme J. Cytokine-regulated proteases in autoimmune diseases. Immunol Today. 1994;15:103–107
  17. Retina Society Terminology Committee . The classification of retinal detachment with proliferative vitreoretinopathy. Ophthalmology. 1983;90:121–125
  18. Masure S, Proost P, Van Damme J, Opdenakker G. Purification and identification of 91-KDa neutrophil gelatinase. Release by the activating peptide interleukin-8. Eur J Biochem. 1991;198:391–398
  19. Van Ranst M, Norga K, Masure S, et al.  The cytokine-protease connection (identification of a 96-KD THP-1 gelatinase and regulation by interleukin-1 and cytokine inducers). Cytokine. 1991;3:231–239
  20. Paemen L, Olsson T, Soderstrom M, Van Damme J, Opdenakker G. Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseases. Eur J Neurol. 1991;1:55–63
  21. Opdenakker G, Masure S, Grillet B, Van Damme J. Cytokine mediated regulation of human leukocyte gelatinases and role in arthritis. Lymphokine Cytokine Res. 1991;10:317–324
  22. Parshley DE, Bradley JMB, Samples JR, Van Buskirk EM, Acott TS. Early changes in matrix metalloproteinases and inhibitors after in vitro laser treatment to the trabecular meshwork. Curr Eye Res. 1995;14:537–544
  23. Senior RM, Griffin GL, Fliszar CJ, Shapiro SD, Goldberg GI, Welgus HG. Human 92- and 72-Kilodalton type IV collagenases are elastases. J Biol Chem. 1991;266:7870–7875
  24. Murphy G, Cookett MI, Ward RV, Docherty AJP. Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycan. A quantitative comparison of the activities of 92 KDa and 72 KDa gelatinases, stromelysins-1 and -2 and punctuated metalloproteinases (PUMP). Biochem J. 1991;277:277–279
  25. Tetlow LC, Lees M, Ogata Y, Nagase H, Wooley DE. Differential expression of gelatinase B (MMP-9) and stromelysin-1 (MMP-3) by rheumatoid synovial cells in vitro and in vivo. Rheumatol Int. 1993;13:53–59
  26. Mohtai M, Smith RL, Schurman DJ, et al.  Expression of 92-KD type IV collagenase/gelatinage (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular centilage by interleukin-1. J Clin Invest. 1993;92:179–185
  27. McMillan WD, Patterson BK, Keen RR, Shively VP, Cipollone M, Pearce WH. In situ localization and quantification of mRNA for 92-KD type IV collagenase and its inhibitor in aneurysmal, occlusive and normal aorta. Arterioscler Thromb Vasc Biol. 1995;15:1139–1144
  28. Freestone T, Turner RJ, Coady A, Higman DJ, Greenhalgh RM, Powell JT. Inflammation and matrix metalloproteinases in the enlarging abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 1995;15:1145–1151
  29. Brown DL, Hibbs MS, Kearney M, Loushin C, Isner JM. Identification of 92-KD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina. Circulation. 1995;91:2125–2131
  30. Albini A, D’Agostini F, Giunciuglio D, Paglieri I, Balansky R, De-flora S. Inhibition of invasion, gelatinase activity, tumor take and metastasis of malignant cells by N-acetylcysteine. Int J Cancer. 1995;61:121–129
  31. Jeziorska M, Haboubi NY, Schofield PF, Ogata Y, Nagase H, Woolley DE. Distribution of gelatinase B (MMP-9) and type IV collagen in colorectal carcinoma. Int J Colorectal Dis. 1994;9:141–148
  32. Mignatti P, Tsuboi R, Robbins E, Rifkin DB. In vitro angiogenesis on the human amniotic membrane (requirement for basic fibroblast growth factor induced proteinases). J Cell Biol. 1989;108:671–682
  33. Mauviel A. Cytokine regulation of metalloproteinase gene expression. J Cell Biochem. 1993;53:288–295
  34. Unemori EN, Hibbs MS, Amento EP. Constitutive expression of a 92 KDa gelatinase (type IV collagenase) by rheumatoid synovial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Clin Invest. 1991;88:1656–1662
  35. Alexander JP, Bradley JMB, Gabourel JD, Acott TS. Expression of matrix metalloproteinases and inhibitor by human retinal pigment epithelium. Invest Ophthalmol Vis Sci. 1990;31:2520–2528
  36. Hunt RC, Fox A, Al Pakalnis V, et al.  Cytokines cause cultured retinal pigment epithelial cells to secrete metalloproteinases and to contract collagen gels. Invest Ophthalmol Vis Sci. 1993;34:3179–3186
  37. Apocada G, Rutka J, Bouhana K, et al.  Expression of metalloproteinases and metalloproteinase inhibitors by fetal astrocytes and glioma cells. Cancer. 1990;50:2322–2329
  38. Glaser BM, Vidaurri-Leal J, Michels RG, Campochiaro PA. Cryotherapy during surgery for giant retinal tears and intravitreal dispersion of viable retinal pigment epithelial cells. Ophthalmology. 1993;100:466–470
  39. Murphy G, Reynolds JJ. Extracellular matrix degradation. In:  Royce PM,  Steinmann B editor. Connective tissue and its heritable disorders. New York: Wiley Liss; 1993;p. 287–316
  40. Leppert D, Waubant E, Galardy R, Bunnett NW, Hauser SL. T cell gelatinases mediate basement membrane transmigration in vitro. J Immunol. 1995;154:4379–4389
  41. Rao JS, Yamamoto M, Mohaman S, et al.  Expression and localization of 92 KDa type IV collagenase/gelatinase B (MMP-9) in human glioma. Clin Exp Metastasis. 1996;14:12–18
  42. Opdenakker G, Masure S, Proost P, Billiau A, Van Damme J. Natural human monocyte gelatinase and its inhibitor. FEBS Letters. 1991;284:73–78
  43. Welgus HG, Campbell EJ, Cury JD, et al.  Neutral metalloproteinases produced by human mononuclear phagocytes. Enzyme profile, regulation, and expression during cellular development. J Clin Invest. 1990;86:1496–1502
  44. Abu El-Asrar AM, Van Damme J, Put W, et al.  Monocyte chemotactic protein 1 in proliferative vitreoretinal disorders. Am J Ophthalmol. 1997;123:599–606
  45. Rollins BJ, Walz A, Baggiolini M. Recombinant human MCP-1/JE induces chemotoxic, calcium flux, and the respiratory burst in human monocytes. Blood. 1991;78:1112–1117
  46. Fisher C, Gilbertson-Beadling S, Powers EA, Petzold G, Poorman R, Mitchell MA. Interstitial collagenase is required for angiogenesis in vitro. Dev Biol. 1994;162:499–510
  47. Moses MA, Langer R. A metalloproteinase inhibitor as an inhibitor of neovascularization. J Cell Biochem. 1991;47:230–235
  48. Anand-Apte B, Pepper MS, Voest E, et al.  Inhibition of angiogenesis by tissue inhibitor of metalloproteinase-3. Invest Ophthalmol Vis Sci. 1997;38:817–823
  49. Rosenberg GA. Matrix metalloproteinases in brain injury. J Neurotrauma. 1995;12:833–842

 This study was supported by the Geconcerteerde OnderzoeksActies (Dr Opdenakker) and by the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (Dr Opdenakker).

PII: S0002-9394(98)00041-5

American Journal of Ophthalmology
Volume 125, Issue 6 , Pages 844-851 , June 1998