American Journal of Ophthalmology
Volume 126, Issue 3 , Pages 373-378 , September 1998

Distribution of prognostically important vascular patterns across multiple levels in ciliary body and choroidal melanomas

  • Mary G. Mehaffey, MD

      Affiliations

    • Department of Ophthalmology and Visual Sciences (Drs Mehaffey and Folberg, and Ms Gardner), University of Iowa, Iowa City, Iowa, USA
  • ,
  • Lynn M. Gardner (HT (ASCP))

      Affiliations

    • Department of Ophthalmology and Visual Sciences (Drs Mehaffey and Folberg, and Ms Gardner), University of Iowa, Iowa City, Iowa, USA
  • ,
  • Robert Folberg, MD

      Affiliations

    • Department of Ophthalmology and Visual Sciences (Drs Mehaffey and Folberg, and Ms Gardner), University of Iowa, Iowa City, Iowa, USA
    • Department of Pathology (Dr Folberg), University of Iowa, Iowa City, Iowa, USA
    • Corresponding Author InformationReprint requests to Robert Folberg, MD, University of Iowa, 100 Medical Research Center, Room 233, Iowa City, IA 52242-1182; fax: (319) 335-7193

,Accepted 2 February 1998.

References 

  1. Hart IR, Fidler IJ. The implications of tumor heterogeneity for studies on the biology and therapy of cancer metastasis. Biochem Biophys Acta. 1981;651:37–50
  2. Rummelt V, Gardner LM, Folberg R, et al.  Three-dimensional relationships between tumor cells and microcirculation using double cyanine-immunolabeling, laser scanning confocal microscopy and computer-assisted reconstruction (an alternative to cast corrosion preparations). J Histochem Cytochem. 1994;42:681–686
  3. de la Cruz POJ, Specht CS, McLean IW. Lymphocytic infiltration in uveal malignant melanoma. Cancer. 1990;65:112–115
  4. Folberg R, Rummelt V  Parys- , Van Ginderdeuren R, et al.  The prognostic value of tumor blood vessel morphology in primary uveal melanoma. Ophthalmology. 1993;100:1389–1398
  5. Folberg R, Donoso LA, Atkinson BF, Ernst CS, Herlyn M, Arbizo VV. An antimelanoma monoclonal antibody and the histopathology of uveal melanoma. Arch Ophthalmol. 1985;103:275–279
  6. Donoso LA, Folberg R, Edelberg K, Arbizo VV, Atkinson BF, Herlyn M. Tissue distribution and biochemical properties of an ocular melanoma-associated antigen. J Histochem Biochem. 1985;33:1190–1196
  7. Folberg R, Augsburger JJ, Gamel JW, Shields JA, Lang WR. Fine-needle aspirates of uveal melanomas and prognosis. Am J Ophthalmol. 1985;100:654–657
  8. Torczynski E. Preparation of ocular specimens for histopathologic examination. Ophthalmology. 1981;88:1367–1371
  9. Shammas HF, Blodi FC. Prognostic factors in choroidal and ciliary body melanomas. Arch Ophthalmol. 1977;95:63–69
  10. Folberg R, Pe’er J, Gruman LM, et al.  The morphologic characteristics of tumor blood vessels as a marker of tumor progression in primary human uveal melanoma (a matched case-control study). Hum Pathol. 1992;23:1298–1305
  11. Mehaffey MG, Folberg R, Meyer M, et al.  Relative importance of quantifying area and vascular patterns in uveal melanoma. Am J Ophthalmol. 1997;123:798–809
  12. Folberg R, Verdick RE, Weingeist TA, Montague PR. Gross examination of eyes removed for ciliary body or choroidal melanoma. Ophthalmology. 1986;93:1643–1647
  13. McLean IW, Keefe KS, Burnier MN. Uveal melanoma (comparison of the prognostic value of fibrovascular loops, mean of the ten largest nucleoli, cell type and tumor size). Ophthalmology. 1997;104:777–780
  14. Hendrix MJC, Seftor EA, Seftor REB, et al.  Regulation of uveal melanoma interconverted phenotype by hepatocyte growth factor/scatter factor (HGF/SF). Am J Pathol. 1998;152:855–863
  15. Hendrix MJC, Seftor EA, Seftor REB, et al.  Biological determinants of uveal melanoma metastatic phenotype (role of intermediate filaments as predictive markers). Lab Invest. 1998;78:153–163
  16. Foss AJE, Alexander RA, Jefferies LW, Hungerford JL, Harris AL, Lightman S. Microvessel count predicts survival in uveal melanoma. Cancer Res. 1996;56:2900–2903
  17. Daniels KJ, Boldt HC, Martin JA, Gardner LM, Meyer M, Folberg R. Expression of type VI collagen in uveal melanoma (role in pattern formation and tumor progression). Lab Invest. 1996;75:55–66
  18. Weidner N, Semple JP, Welch WR, Folkman J. Tumor angiogenesis and metastasis (correlation in invasive breast carcinoma). N Engl J Med. 1991;324:1–8
  19. Lane AM, Egan KM, Gragoudas ES, et al.  An evaluation of tumour vascularity as a prognostic indicator in uveal melanoma. Melanoma Res. 1997;7:237–242
  20. Weidner N. Current pathologic methods for measuring intratumoral microvessel density within breast carcinoma and other solid tumors. Breast Cancer Res Treat. 1995;36:169–180
  21. Sakamoto T, Sakamoto M, Yoshikawa H, et al.  Histologic findings and prognosis of uveal malignant melanoma in Japanese patients. Am J Ophthalmol. 1996;121:276–283
  22. Foss AJE, Alexander RA, Hungerford JL, Harris AL, Cree IA, Lightman S. Re-assessment of the PAS patterns in uveal melanoma. Br J Ophthalmol. 1997;81:240–246
  23. Makitie T, Summanen P, Kivela T. Fibrovascular loops and networks in choroidal and ciliary body melanomas [abstract]. Ophthalmic Res. 1997;29(1 suppl):136–136
  24. Coleman DJ, Rondeau MJ, Silverman RH, et al.  Correlation of microcirculation architecture with ultrasound parameters of uveal melanoma. Eur J Ophthalmol. 1995;5:96–106
  25. Silverman RH, Folberg R, Boldt HC, et al.  Correlation of ultrasound parameter imaging with microcirculatory patterns in uveal melanomas. Ultrasound Med Biol. 1997;23:573–581
  26. Schneider U, Gelisken F, Inhoffen W, Kreissig I. Indocyanine-green videoangiography of malignant melanomas of the choroid using the scanning laser ophthalmoscope. Ger J Ophthalmol. 1996;5:6–11
  27. Mueller AJ, Bartsch D-U, Folberg R, et al.  Imaging the microvasculature of choroidal melanomas with confocal indocyanine green scanning laser ophthalmoscopy. Arch Ophthalmol. 1998;116:31–39
  28. Mooy CM, De Jong PTVM. Prognostic parameters in uveal melanoma (a review). Surv Ophthalmol. 1996;41:215–228
  29. Albert DM. The ocular melanoma story (53rd Edward Jackson Memorial Lecture, part 2). Am J Ophthalmol. 1997;123:729–741
  30. Shields JA, Shields CL, Ehya H, Eagle RC, De Potter P. Fine-needle aspiration biopsy of suspected intraocular tumors. The 1992 Urwick Lecture. Ophthalmology. 1993;100:1677–1684
  31. Char DH. Diagnosis of choroidal melanoma. In:  Ryan SJ editors. Retina. St Louis: Mosby; 1994;p. 725–741
  32. Augsburger JJ, Shields JA, Folberg R, Lang WR, O’Hara BJ, Claricci JD. Fine needle aspiration biopsy in the diagnosis of intraocular cancer cytologic-histologic correlations. Ophthalmology. 1985;92:39–49
  33. Char DH, Kroll SM, Stoloff A, et al.  Cytomorphometry of uveal melanoma (comparison of fine needle aspiration biopsy samples with histologic sections). Anal Quant Cytol Histol. 1991;13:293–299
  34. DeMay RM. In: The art and science of cytopathology. Chicago: ASCP Press; 1996;p. 463

 This study was supported by grant EY10457 from the National Institutes of Health, Bethesda, Maryland (Dr Folberg) and in part by an unrestricted grant from Research to Prevent Blindness, Inc, New York, New York.

PII: S0002-9394(98)00092-0

American Journal of Ophthalmology
Volume 126, Issue 3 , Pages 373-378 , September 1998