Supplemental Material

View select materials by clicking on the links provided below. Videos will be presented in streaming format in a pop-up window, so there is no need to wait for the movie to download before you watch it.

Quality of Life in Keratoconus Patients After Penetrating Keratoplasty
Elvin H. Yildiz, Elisabeth J. Cohen, Ajoy S. Virdi, Kristin M. Hammersmith, Peter R. Laibson, Christopher J. Rapuano
published March 2010
Full Text | Journal Format-PDF (558 KB)
Supplementary data

Mycophenolate Mofetil for Ocular Inflammation
Ebenezer Daniel, Jennifer E. Thorne, Craig W. Newcomb, Siddharth S. Pujari, R. Oktay Kaçmaz, Grace A. Levy-Clarke, Robert B. Nussenblatt, James T. Rosenbaum, Eric B. Suhler, C. Stephen Foster, Douglas A. Jabs, John H. Kempen
published March 2010
Full Text | Journal Format-PDF (278 KB)
Appendix

Late Varicella-Zoster Virus Dendriform Keratitis in Patients With Histories of Herpes Zoster Ophthalmicus
Allen Y.H. Hu, Erich C. Strauss, Gary N. Holland, Matilda F. Chan, Fei Yu, Todd P. Margolis
published February 2010
Full Text | Journal Format-PDF (1110 KB)
Representative Case Histories

Serous Retinal Detachment Associated With Retinal Vein Occlusion
Akitaka Tsujikawa, Atsushi Sakamoto, Masafumi Ota, Yuriko Kotera, Hideyasu Oh, Kazuaki Miyamoto, Mihori Kita, Nagahisa Yoshimura
published February 2010
Full Text | Journal Format-PDF (4678 KB)
Supplemental Figure 1. Typical macular edema associated with branch retinal vein occlusion. (Top) Fundus photograph (left) and fluorescein angiogram (right) at the initial visit. Visual acuity was 20/100. (Bottom) Horizontal sectional image with optical coherence tomography along the white arrow indicated in the fundus photograph obtained at the initial visit. Marked retinal swelling is seen, most prominently in the outer retina. A large cystoid space is seen in the fovea, and accompanies numerous small cystoid spaces. A small serous retinal detachment is seen beneath the fovea. The lines corresponding to the external limiting membrane (ELM) and the junction between inner and outer segments of the photoreceptors (IS/OS) are seen beneath the thickened outer nuclear layer. RPE = retinal pigment epithelium.
Supplemental Figure 2. Development of a pointed retinal detachment (RD) in an eye with no RD. (Top row) Fundus photograph (Left) and fluorescein angiogram (Right) at the initial visit in an eye with macular edema associated with hemi central retinal vein occlusion. (2nd row) Horizontal (Left) and vertical (Right) sectional images with optical coherence tomography along the white arrows in the fundus photograph obtained at the initial visit. Visual acuity was 20/20, and no serous RD was seen. (3rd row) One week later, a small pointed RD is seen just beneath the fovea. Visual acuity was still 20/15. (Bottom row) Two months after the initial visit, macular edema has increased substantially, with a larger-appearing pointed RD just beneath the fovea. Visual acuity was decreased to 20/40.
Supplemental Figure 3. Track of the intraretinal passage, through which intraretinal fluid within the cystoid spaces had been flowing into the subretinal space seen in eyes with macular edema associated with branch retinal vein occlusion (Top) and central retinal vein occlusion (Bottom). The track of passage appears as highly reflective lines.
Supplemental Figure 4. Focal defect of the inner and outer segments of the photoreceptors above the serous retinal detachment associated with retinal vein occlusion. (Top) Fundus photograph (Left) and fluorescein angiogram (Right) at the initial visit. (Middle and Bottom) Sectional images (Middle along the white arrow a and Bottom along the white arrow b) obtained with optical coherence tomography show a focal defect of the inner and outer segments of the photoreceptors (arrows) subfoveally above the dome-shaped retinal detachment. The line corresponding to the external limiting membrane is seen to be continuous. Visual acuity was 20/50.

Vision-Related Function After Scleral Lens Fitting in Ocular Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Bénédicte Tougeron-Brousseau, Agnès Delcampe, Julie Gueudry, Lisa Vera, Serge Doan, Thanh Hoang-Xuan, Marc Muraine
published December 2009
Full Text | Journal Format-PDF (1013 KB)
Supplemental Figure 1. Right eye of a patient with Stevens-Johnson syndrome showing corneal keratinization and neovascularization.
Supplemental Figure 2. Same patient as in Supplemental Supplemental Figure 1 wearing a gas-permeable scleral contact lens.

Incorporating Mortality Risk into Estimates of 5-Year Glaucoma Risk
Beth Ann Griffin, Marc N. Elliott, Anne L. Coleman, Eric M. Cheng
published December 2009
Full Text | Journal Format-PDF (1066 KB)
Supplemental Appendix A
Supplemental Appendix B
Supplemental Appendix C
Supplemental Appendix D

Fundus-Based and Electroretinographic Strategies for Stratification of Late-Stage Vogt-Koyanagi-Harada Disease Patients
Felipe Theodoro da Silva, Carlos Eduardo Hirata, Edilberto Olivalves, Maria Kiyoko Oyamada, Joyce Hisae Yamamoto
published December 2009
Full Text | Journal Format-PDF (1678 KB)
Appendix

Bevacizumab in Inflammatory Eye Disease
McGregor N. Lott, Joyce C. Schiffman, Janet L. Davis
published November 2009
Full Text | Journal Format-PDF (504 KB)
Supplemental Figure 1. Box plot illustrating the distribution of the visual acuities (VA) (logarithm of minimal angle of resolution [logMAR]) of eyes with inflammatory choroidal neovascularization (CNV) at baseline and at 1, 3, 6, and 12 months of follow-up.
Supplemental Figure 2. Box plot illustrating the distribution of the macular thicknesses (central subfield thicknesses [CST], as measured by optical coherence tomography [OCT]) of eyes with inflammatory CNV at baseline and at 1, 3, 6, and 12 months of follow-up.
Supplemental Figure 3. Box plot illustrating the distribution of the VAs (logMAR) of eyes with inflammatory cystoid macular edema (CME) at baseline and at 1, 3, 6, and 12 months of follow-up.
Supplemental Figure 4. Box plot illustrating the distribution of the macular thicknesses (CST, as measured by OCT) of eyes with inflammatory CME at baseline and at 1, 3, 6, and 12 months of follow-up.

SCORE Study Report 7: Incidence of Intravitreal Silicone Oil Droplets Associated With Staked-on vs Luer Cone Syringe Design
Ingrid U. Scott, Neal L. Oden, Paul C. VanVeldhuisen, Michael S. Ip, Barbara A. Blodi, Andrew N. Antoszyk, The SCORE Study Investigator Group
published November 2009
Full Text | Journal Format-PDF (1312 KB)
The SCORE Study Investigator Group

Acanthamoeba Keratitis: Diagnosis and Treatment Update 2009
John K.G. Dart, Valerie P.J. Saw, Simon Kilvington
published October 2009
Full Text | Journal Format-PDF (950 KB)
Supplemental Text. Laboratory Diagnosis

Azathioprine for Ocular Inflammatory Diseases
Sirichai Pasadhika, John H. Kempen, Craig W. Newcomb, Teresa L. Liesegang, Siddharth S. Pujari, James T. Rosenbaum, Jennifer E. Thorne, C. Stephen Foster, Douglas A. Jabs, Grace A. Levy-Clarke, Robert B. Nussenblatt, Eric B. Suhler
published October 2009
Full Text | Journal Format-PDF (674 KB)
Supplemental Table. Characteristics of Eyes with Ocular Inflammation Upon Initiation of Azathioprine, by Type of Inflammation

A Study of Interactions between Pharmaceutical Representatives and Ophthalmology Trainees
Yue Wang, Ron A. Adelman
published October 2009
Full Text | Journal Format-PDF (1017 KB)
Supplemental Appendix (Questionnaire).

Testability of Vision and Refraction in Preschoolers: The Strabismus, Amblyopia, and Refractive Error Study in Singaporean Children
Michelle J. Trager, Mohamed Dirani, Qiao Fan, Gus Gazzard, Prabakaran Selvaraj, Audrey Chia, Tien-Yin Wong, Terri L. Young, Rohit Varma, Seang-Mei Saw
published July 2009
Full Text | Journal Format-PDF (2051 KB)
Supplemental Figure 1. IOLMaster.
Supplemental Figure 2. Retinomax hand-held autorefractor.
Supplemental Figure 3. Sheridan Gardiner chart.
Supplemental Figure 4. Randot Preschool Stereoacuity test.
Supplemental Figure 5. Nonilluminated Early Treatment Diabetic Retinopathy Study chart with Sloan letters.
Supplemental Figure 6. Canon Autorefractor RK-F1.
Supplemental Figure 7. Ishihara color test.

Intravitreal Bevacizumab for Diabetic Macular Edema Associated With Severe Capillary Loss: One-Year Results of a Pilot Study
Marco Bonini-Filho, Rogério A. Costa, Daniela Calucci, Rodrigo Jorge, Luiz A.S. Melo, Ingrid U. Scott
published June 2009
Full Text | Journal Format-PDF (4895 KB)
Supplemental Figure 1. Fluorescein angiograms (FA) (negative images) at baseline (Top left, Patient 1; Top right, Patient 9; Bottom left, Patient 5; Bottom right, Patient 2) exemplifying severe capillary loss in 4 different patients with diabetic macular edema (DME) treated with intravitreal bevacizumab (same patients illustrated in Figure 2 in the text).
Supplemental Figure 2. Color fundus photography and optical coherence tomography (OCT) evaluation at baseline and at weeks 8, 16, 24, and 52 of 1 patient with DME associated with severe capillary loss treated with intravitreal bevacizumab (Patient 6).
Supplemental Figure 3. Red-free fundus photography and OCT evaluation at baseline and at weeks 8, 16, 24, and 54 of 1 patient with DME associated with severe capillary loss treated with intravitreal bevacizumab (Patient 3).
Supplemental Figure 4. FA at baseline and at weeks 8, 16, 24, and 52 of 1 patient with DME associated with severe capillary loss treated with intravitreal bevacizumab (same patient illustrated in Figure 2).
Supplemental Figure 5. FA at baseline and at weeks 8, 16, 24, and 54 of 1 patient with DME associated with severe capillary loss treated with intravitreal bevacizumab (same patient illustrated in Figure 3).

ARMS2 (LOC387715) Variants in Japanese Patients with Exudative Age-related Macular Degeneration and Polypoidal Choroidal Vasculopathy
Norimoto Gotoh, Hideo Nakanishi, Hisako Hayashi, Ryo Yamada, Atsushi Otani, Akitaka Tsujikawa, Kenji Yamashiro, Hiroshi Tamura, Masaaki Saito, Kuniharu Saito, Tomohiro Iida, Fumihiko Matsuda, Nagahisa Yoshimura
published June 2009
Full Text | Journal Format-PDF (607 KB)
Supplemental Table. Sequence Primers for ARMS2 Gene Lesion

Dexamethasone Posterior-Segment Drug Delivery System in the Treatment of Macular Edema Resulting from Uveitis or Irvine-Gass Syndrome
George A. Williams, Julia A. Haller, Baruch D. Kuppermann, Mark S. Blumenkranz, David V. Weinberg, Connie Chou, Scott M. Whitcup, The Dexamethasone DDS Phase II Study Group
published June 2009
Full Text | Journal Format-PDF (1028 KB)
Supplemental Figure. Diagram showing patient progress through the study of the dexamethasone posterior-segment intravitreous drug delivery system (dexamethasone DDS) in the treatment of macular edema resulting from uveitis or Irvine-Gass syndrome.

Trabeculectomy With or Without Intraoperative Sub-Tenon Injection of Triamcinolone Acetonide in Treating Secondary Glaucoma
Kenya Yuki, Daisuke Shiba, Itaru Kimura, Yuichiro Ohtake, Kazuo Tsubota
published June 2009
Full Text | Journal Format-PDF (407 KB)
Supplemental Figure. Flow chart shows the total numbers of eyes enrolled, operated, and observed during the follow-up of the study.

Development and Validation of a Digital Head Posture Measuring System
Eric S. Hald, Richard W. Hertle, Dongsheng Yang
published June 2009
Full Text | Journal Format-PDF (2999 KB)
Supplemental Appendix.

A Modified Evisceration Technique with Scleral Quadrisection and Porous Polyethylene Implantation
Danping Huang, Yangyang Yu, Rong Lu, Huasheng Yang, Jianhao Cai
published May 2009
Full Text | Journal Format-PDF (3612 KB)
Supplemental Figure 1. Postevisceration motility. The motility of the implant (left eye) of patient 2 is satisfactory. Front gaze.
Supplemental Figure 2. Postevisceration motility. The motility of the implant (left eye) of patient 2 is satisfactory. Up gaze.
Supplemental Figure 3. Postevisceration motility. The motility of the implant (left eye) of patient 2 is satisfactory. Down gaze.
Supplemental Figure 4. Postevisceration motility. The motility of the implant (left eye) of patient 2 is satisfactory. Left gaze.
Supplemental Figure 5. Postevisceration motility. The motility of the implant (left eye) of patient 2 is satisfactory. Right gaze. One year after operation for this patient.

Chronic Anterior Uveitis in Children: Clinical Characteristics and Complications
Gary N. Holland, Christopher S. Denove, Fei Yu
published April 2009
Full Text | Journal Format-PDF (1522 KB)
Supplemental Table 1. Conversion of Categorical Values for Anterior Chamber Cells to Numerical Values for Purpose of Analysis
Supplemental Table 2. Relationships Between Vision-Threatening Complications at Baseline Examination for 200 Eyes of 115 Children With Chronic Anterior Uveitis

Pathogenesis and Outcome of Paecilomyces Keratitis
Xiaoyong Yuan, Kirk R. Wilhelmus, Alice Y. Matoba, George Alexandrakis, Darlene Miller, Andrew J.W. Huang
published April 2009
Full Text | Journal Format-PDF (1583 KB)
Supplemental Table 1. Clinical Characteristics of Patients with Paecilomyces Keratitis
Supplemental Table 2. Previously Reported Cases of Exogenous Paecilomyces Keratitis Having Outcome Information
Supplemental Figure 1. Branching hyphae and conidiophores of P. lilacinus, with cluster of 3 tapered phialides bearing tangled chains of fusiform, unicellular conidia
Supplemental Figure 2. Histopathology of P. lilacinus keratitis corneal button (case 5) obtained 10 days after beginning topical amphotericin B and natamycin shows septate hyphae overswarming the stroma (periodic acid-Schiff; original magnification, ×400).
Supplemental Figure 3. Experimental P. lilacinus infection of explanted donor cornea maintained in tissue-culture medium. Hyphae penetrate stromal lamellae at various angles, with adventitious production of fungal conidia (PAS, ×200).

Five-year Follow-up Optic Disc Findings of the Collaborative Initial Glaucoma Treatment Study
Richard K. Parrish II; William J. Feuer; Joyce C. Schiffman; Paul R. Lichter; David C. Musch; The CIGTS Optic Disc Study Group
published April 2009
Full Text | Journal Format-PDF (494 KB)
Supplemental Figure. Glaucomatous progression in a patient in the Collaborative Initial Glaucoma Treatment Study 5-year optic disc study with intraocular pressure reduction from 33mm Hg to 21 mm Hg, 65 months after randomization to medical therapy. (Left) Before therapy. (Right) Sixty-five months after therapy.
Supplemental Table. Eyes with Five-Year follow-up that were Gradable for Disc Change Status Compared for Selected Eye and Patient Characteristics with Those Ungradable Either Because Stereoscopic Photographs were not Available or Because They were of Insufficient Quality to Judge Progression

Correlation Among Choroidal, Parapapillary, and Retrobulbar Vascular Parameters in Glaucoma
Sunil Deokule; Gianmarco Vizzeri; Andreas G. Boehm; Christopher Bowd; Felipe A. Medeiros; Robert N. Weinreb
published April 2009
Full Text | Journal Format-PDF (1278 KB)
Supplemental Figure 1. Dialog box for perfusion analysis of averaged flow map including superior parapapillary retina and optic nerve head. The map is separated into nasal and temporal parapapillary retina by placing the outer circle at the disc margin to exclude the optic disc from analysis.
Supplemental Figure 2. Averaged flow image of temporal retina area after automatic exclusion of big vessels and graphic presentation of heartbeat-associated pulsation of capillary blood flow. Data window on the right gives mean, standard deviation, minimum, and maximum blood flow values.

Effect of Patient Motivation on Near Vision in Pseudophakic Patients
Christina Leydolt, Thomas Neumayer, Ana Prinz, Oliver Findl
published March 2009
Full Text | Journal Format-PDF (527 KB)
Supplemental Table. Questionnaire Performed Three Months and One-Year Postoperatively

High-speed Optical Coherence Tomography for Imaging Anterior Chamber Inflammatory Reaction in Uveitis: Clinical Correlation and Grading
Amar Agarwal, Dhivya Ashokkumar, Soosan Jacob, Athiya Agarwal, Yoga Saravanan
published March 2009
Full Text | Journal Format-PDF (764 KB)
Supplemental Text.

Wavefront-Guided Retreatment After Primary Wavefront-Guided Laser In Situ Keratomileusis in Myopes and Hyperopes: Long-term Follow-up
Shahram Kashani, Madhavan Rajan, David Gartry
published March 2009
Full Text | Journal Format-PDF (573 KB)
Supplemental Table. Refractive Outcome Prior to Laser In Situ Keratomileusis, Preretreatment and Postretreatment for Myopes and Hyperopes

The Effect of ABO Blood Incompatibility on Corneal Transplant Failure in Conditions with Low-risk of Graft Rejection
Steven P. Dunn, Walter J. Stark, R. Doyle Stulting, Jonathan H. Lass, Alan Sugar, Mark A. Pavilack, Patricia W. Smith, Jean Paul Tanner, Mariya Dontchev, Robin L. Gal, Roy W. Beck, Craig Kollman, Mark J. Mannis, Edward J. Holland, Cornea Donor Study Investigator Group
published March 2009
Full Text | Journal Format-PDF (131 KB)
Cornea Donor Study Investigator Group

Prospective Comparison of Two Suturing Techniques of Amniotic Membrane Transplantation for Symptomatic Bullous Keratopathy
Ugur E. Altiparmak, Yusuf Oflu, Elvin H. Yildiz, Koray Budak, Bekir Sitki Aslan, Ayse Nurozler, Mustafa Onat, Remzi Kasim, Sunay Duman
published March 2009
Full Text | Journal Format-PDF (324 KB)
Supplemental Video.

Associations Between Macular Findings by Optical Coherence Tomography and Visual Outcomes After Epiretinal Membrane Removal
Min Hee Suh, Jong Mo Seo, Kyu Hyung Park, Hyeong Gon Yu
published March 2009
Full Text | Journal Format-PDF (1344 KB)
Supplemental Figure 1. Optical coherence tomography (OCT) images of an epiretinal membrane (ERM) preoperatively and postoperatively, showing new disruption of the line representing the junction between the inner and outer segments of photoreceptors (IS/OS junction) postoperatively. Figures on the right are magnified images of those on the left. A 77-year-old woman with a grade 1 nuclear cataract and a preoperative best-corrected visual acuity (BCVA) of 20/50 in the left eye. She underwent pars plana vitrectomy (PPV) with ERM removal and combined cataract surgery. Three months later, the ERM was found to have been well removed, and her BCVA was 20/40. (Top) Stratus OCT showed a well-preserved IS/OS junction with average macular thickness of 386 µm. (Bottom) Stratus OCT showed disruption of the IS/OS junction in the fovea and affected retina (solid arrows), which contrasted with a well-preserved IS/OS junction in the unaffected retina (dotted arrows) at 3 months postoperatively, although the ERM had been well removed and the retinal structure achieved an almost normal contour with average macular thickness of 298 µm.
Supplemental Figure 2. Postoperative 3-month red-free photograph (Top), early-phase fluorescein angiogram (FA) (Bottom left), and late-phase FA (Bottom right) of a 69-year-old woman who underwent PPV with ERM removal and combined cataract surgery (the same patient as Figure 2). ERM was well removed, and abnormal findings such as leakage and window defect on retina were not found.

Genome-wide Scan of African-American and White Families for Linkage to Myopia
Elise Ciner, Grace Ibay, Robert Wojciechowski, Debra Dana, Taura N. Holmes, Joan E. Bailey-Wilson, Dwight Stambolian
published March 2009
Full Text | Journal Format-PDF (111 KB)
Supplemental Table 1. Detailed MFMAP Results for the Two-point and Multipoint Linkage Using the African-American Samples
Supplemental Table 2. Detailed MFMAP Results for the Two-point and Multipoint Linkage in the White Families

A Comparison of Vitamin A and Cyclosporine A 0.05% Eye Drops for Treatment of Dry Eye Syndrome
Eun Chul Kim, Jun-Sub Choi, Choun-Ki Joo
published February 2009
Full Text | Journal Format-PDF (1354 KB)
Supplemental Figure 1. Bar graph showing the change in photophobia from baseline after treatment with topical cyclosporine 0.05%, topical retinyl palmitate 0.05%, or artificial lubricants alone in patients with dry eye syndrome. The decrease from baseline in photophobia was statistically significant in the vitamin A group at two months (*P < .05, Wilcoxon signed-rank test). Statistically significant decreases in photophobia were observed in all treatment groups at month 3 (P < .05). Values are mean ± standard error and were graded on a scale from 0 through 4. Control = Refresh Plus alone; O-CS = cyclosporine 0.05%; O-Viva = retinyl palmitate 0.05%.
Supplemental Figure 2. Photomicrographs showing the change in impression cytologic analysis grade from baseline after treatment with topical cyclosporine 0.05%, topical retinyl palmitate 0.05%, or artificial lubricants in patients with dry eye syndrome. Improvement in impression cytologic analysis results was shown after three months in the vitamin A group: (Top left) stage 2, initial; (Top right) stage 1, after three months; and in the cyclosporine 0.05% group: (Middle left) stage 2, initial; (Middle right) stage 1, after three months. However, there was no improvement in impression cytologic analysis results after three months in the control group: (Bottom left) stage 2, initial; (Bottom right) stage 2, after three months) (x100, PAS-hematoxylin stain). Control = Refresh Plus alone; stage 0 = normal; stage 1 = early loss of goblet cells; stage 2 = total loss of goblet cells; stage 3 = early keratinization; stage 4 = moderate keratinization; stage 5 = advanced keratinization.

Treatment of Adult-Onset Acute Macular Retinoschisis in Enhanced S-cone Syndrome With Oral Acetazolamide
Alessandro Iannaccone, Kenneth H. Fung, Mari E. Eyestone, Edwin M. Stone
published February 2009
Full Text | Journal Format-PDF (722 KB)
Supplemental Figure. Results of the molecular genetic NR2E3 testing conducted on this patient, revealing a homozygous CGG to CAG nucleotide change predicting a non-conservative Arginine to Glutamine (Arg-311-Gln or R311Q) amino acid change in the protein sequence, which has been previously associated with enhanced S-cone syndrome.

Revised Diagnostic Criteria for Vogt-Koyanagi-Harada Disease: Considerations on the Different Disease Categories
Felipe Theodoro Bezerra Gaspar Carvalho da Silva, Francisco Max Damico, Maria Lucia Marin, Anna Carla Goldberg, Carlos Eduardo Hirata, Pedro Henrique Takiuti, Edilberto Olivalves, Joyce Hisae Yamamoto
published February 2009
Full Text | Journal Format-PDF (831 KB)
Supplemental Table. HLA-DR and DQ Typing of the 67 Brazilian Patients With Vogt-Koyanagi-Harada Disease From HCFMUSP
Supplemental Figure 1. Clinical characteristics of a patient with Vogt-Koyanagi-Harada (VKH) in the acute phase. (Top left and right) Fundus pictures of both eyes show disc hyperemia, white-yellowish choroidal lesions, localized exudative retinal detachments (RDs). (2nd row, left and right) Fluorescein angiography of both eyes show pin-point hyperfluorescence and dye pooling corresponding to areas of RDs. (3rd row, left and right) Optical coherence tomography shows serous RD. (Bottom left and right) Ocular ultrasound demonstrates diffuse wall thickening and serous RD.
Supplemental Figure 2. Clinical characteristics of a patient with VKH in the late phase. (Top left and right) Fundus picture of both eyes shows diffuse retinal depigmentation and atrophy, with intense pigment clumping and migration. (Middle left and right) Fluorescein angiography of both eyes show diffuse window retinal pigment epithelium defects. (Bottom left and right) Indocyanine green angiography shows areas of hypofluorescence corresponding to areas of fibrosis. Diffuse late hyperfluorescence.

Longitudinal Cohort Study of Patients with Birdshot Chorioretinopathy. V. Quality of Life at Baseline
Ralph D. Levinson, Dominique Monnet, Fei Yu, Gary N. Holland, Peter Gutierrez, Antoine P. Brezin
published February 2009
Full Text | Journal Format-PDF (302 KB)
Supplemental Table. Comparison of Selected Visual Function Parameters to Decreased National Eye Institute Visual Function Questionnaire-25 Subscale Scores for 80 Patients with Birdshot Chorioretinopathy

Predicting Visual Outcome After Treatment of Pituitary Adenomas With Optical Coherence Tomography
Maud Jacob, Gérald Raverot, Emmanuel Jouanneau, Françoise Borson-Chazot, Gilles Perrin, Muriel Rabilloud, Caroline Tilikete, Martine Bernard, Alain Vighetto
published January 2009
Full Text | Journal Format-PDF (320 KB)
Supplemental Table 1. Reproducibility of the Three Consecutive Measurements of Retinal Nerve Fiber Layer Thickness by Optical Coherence Tomography in 37 Eyes From 19 Consecutive Patients Suffering From Pituitary Adenomas Compressing the Anterior Visual Pathways
Supplemental Table 2. Percentage of Reduction of Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in 37 Eyes From 19 Consecutive Patients Suffering From Pituitary Adenomas Compressing the Anterior Visual Pathways

Polymerase Chain Reaction Analysis of Aqueous and Vitreous Specimens in the Diagnosis of Posterior Segment Infectious Uveitis
Thomas W. Harper, Darlene Miller, Joyce C. Schiffman, Janet L. Davis
published January 2009
Full Text | Journal Format-PDF (343 KB)
Supplemental Table 9. Change in Therapy after Polymerase Chain Reaction Testing in Infectious Uveitis of the Posterior Segment

Intraocular Inflammation Associated with Ocular Toxoplasmosis: Relationships at Initial Examination
Emilio M. Dodds, Gary N. Holland, Miles R. Stanford, Fei Yu, Willie O. Siu, Kayur H. Shah, Ninette ten Dam-van Loon, Cristina Muccioli, Anna Hovakimyan, Talin Barisani-Asenbauer, International Ocular Toxoplasmosis Research Group
published December 2008
Full Text | Journal Format-PDF (782 KB)
Supplemental Table. Relationships between Anterior Chamber and Vitreous Humor Measures of Inflammation for 210 Patients with Ocular Toxoplasmosis at Initial Examination

Incidence and Prevalence of Uveitis in Veterans Affairs Medical Centers of the Pacific Northwest
Eric B. Suhler, Michael J. Lloyd, Dongseok Choi, James T. Rosenbaum, Donald F. Austin
published December 2008
Full Text | Journal Format-PDF (1396 KB)
Supplemental Figure 2. Graph showing the size of population at selected time points. The horizontal axis is the time (fiscal year ends marked); the vertical (dotted) axis is the size of the population at the selected time point; the area within the box is the total person-time during fiscal year 2004 (FY04). Assumptions include a stable rate of influx and efflux during the year. * = fiscal year end total user populations; § = FY04 midpoint. Person-time estimate and midpoint population estimate: 117,833 + [(29,458 + 39,410)/2] = 152,267. A similar methodology was used for age- and gender-specific subgroups. FY03 = fiscal year 2003.
Supplemental Table 6. Comparative Crude Age- and Gender-Specific Incidence Rates from Current Study, Gritz and Wong/Northern California Epidemiology of Uveitis Study (2004), and Darrell and Associates (1962)
Supplemental Table 7. Incidence Data from Gritz and Wong and Darrell and Associates after Direct Age and Gender Adjustment to Veterans Affairs Study Population Standard
Supplemental Table 8. Comparative Crude Age- and Gender-Specific Prevalence Ratios from Current Study and Gritz and Wong/Northern California Epidemiology of Uveitis Study
Supplemental Table 9. Prevalence Data from Gritz and Wong/Northern California Epidemiology of Uveitis Study after Direct Age and Gender Adjustment to Veterans Affair Study Population Standard
Supplemental Table 10. Comparative Crude Age- and Gender-Specific Prevalence Ratios from Current Study Using Enrollees and Users as the Denominator
Supplemental Data. Uveitis Codes Used in the Northern California Epidemiology of Uveitis Study

Japan Ministry of Health Study on Prevalence of Dry Eye Disease Among Japanese High School Students
Miki Uchino, Murat Dogru, Yuichi Uchino, Kazumi Fukagawa, Shigeto Shimmura, Toru Takebayashi, Debra A. Schaumberg, Kazuo Tsubota
published December 2008
Full Text | Journal Format-PDF (505 KB)
Supplemental Material: Questionnaire

Diabetic Macular Edema: What Is Focal and What Is Diffuse?
David J. Browning, Michael M. Altaweel, Neil M. Bressler, Susan B. Bressler, Ingrid U. Scott, Diabetic Retinopathy Clinical Research Network
published November 2008
Full Text | Journal Format-PDF (162 KB)
Supplemental Table 1. Diffuse Edema: Clinical Examination or Fundus Photography
Supplemental Table 2. Diffuse Edema: Fluorescein Angiography
Supplemental Table 3. Diffuse Edema: Optical Coherence Tomography
Supplemental Table 4. Diffuse Edema: Comments
Supplemental Table 5. Focal Diabetic Macular Edema: Clinical Examination or Fundus Photography
Supplemental Table 6. Focal Diabetic Macular Edema: Fluorescein Angiography
Supplemental Table 7. Focal Diabetic Macular Edema: Comments

Prospective Comparison of Microbial Culture and Polymerase Chain Reaction in the Diagnosis of Corneal Ulcer
Elma Kim, Jaya D. Chidambaram, Muthiah Srinivasan, Prajna Lalitha, Daniel Wee, Thomas M. Lietman, John P. Whitcher, Russell N. Van Gelder
published November 2008
Full Text | Journal Format-PDF (229 KB)
Supplemental Methods.

Mycophenolate Mofetil for the Treatment of Uveitis
Stephen C. Teoh, Aideen C. Hogan, Andrew D. Dick, Richard W.J. Lee
published November 2008
Full Text | Journal Format-PDF (942 KB)
Supplemental Figure. Comparisons between this series of mycophenolate mofetil (MMF) therapy for uveitis and other Standardization of Uveitis Nomenclature (SUN)-compliant reports. (Top) Probability of achieving 10 mg prednisone daily and discontinuing prednisone: comparison between this series (BEH) and an approximated data-set from the Wilmer Eye Institute (WEI) report (which included nonuveitic ocular inflammations).17 (Middle) Probability of achieving each prednisone threshold: comparison between this series MMF and our previous report of tacrolimus therapy for uveitis (Tac).24 (Bottom) Probability of drug discontinuation attributable to intolerance: comparison between MMF and Tac.

Non-Descemet Stripping Automated Endothelial Keratoplasty for Endothelial Dysfunction Secondary to Argon Laser Iridotomy
Akira Kobayashi, Hideaki Yokogawa, Kazuhisa Sugiyama
published October 2008
Full Text | Journal Format-PDF (1137 KB)
Supplementary Video. Surgical technique video of double-glide aided pull-through method of donor endothelial lamella insertion. (Kobayashi double-glide donor insertion technique). The intraocular lens (IOL) implantation sheet glide was trimmed and inserted into the anterior chamber (AC) through a 5.0-mm incision to prevent iris prolapse. Then, the Busin glide was loaded with the donor endothelial lamella, endothelial side up. Several drops of Healon were dropped onto the donor lamella. The donor lamella then was pulled into the Busin glide opening. The Busin glide was inverted and positioned at the entrance of a nasal clear-corneal tunnel. A 25-gauge anterior capsular forceps was passed through a temporal paracentesis wound across the AC to grasp the donor lamella from the spatula. The donor lamella was pulled into the AC and left to unfold spontaneously under continuous irrigation. The IOL sheet glide then was removed. After securing the wound with interrupted 10-0 nylon sutures, air was injected to attach the donor lamella to the posterior stromal surface.

Distinguishing Between Infectious and Noninfectious Endophthalmitis After Intravitreal Triamcinolone Injection
Daniel B. Roth, Harry W. Flynn
published September 2008
Full Text | Journal Format-PDF (641 KB)
Supplemental Figure 1. Eye with infectious endophthalmitis after intravitreal triamcinolone acetonide (IVTA) injection. Note the hyperemia and chemosis of the conjunctiva. The anterior chamber (AC) is hazy attributable to inflammatory cells with associated fibrin and a yellow-white hypopyon.
Supplemental Figure 2. Eye with noninfectious endophthalmitis after IVTA injection. Note the yellow-white nature of the hypopyon with some associated hemorrhage in the inferior angle. Some conjunctival hyperemia is present, but this may often be absent.
Supplemental Figure 3. Eye with pseudoendophthalmitis after IVTA injection. Note the white collection of clumped triamcinolone particles on the inferior corneal endothelium and the hazy AC attributable to suspended triamcinolone crystals.
Supplemental Figure 4. Eye with pseudoendophthalmitis after IVTA injection. Note the chalk-white pseudohypopyon attributable to the collection of triamcinolone crystals in the AC. A dusting of the crystals on the corneal endothelium in the absence of fibrin can often been seen.

Longitudinal Study of New Eye Lesions in Children with Toxoplasmosis Who Were Not Treated During the First Year of Life
Laura Phan, Kristen Kasza, Jessica Jalbrzikowski, A. Gwendolyn Noble, Paul Latkany, Annie Kuo, William Mieler, Sanford Meyers, Peter Rabiah, Kenneth Boyer, Charles Swisher, Marilyn Mets, Nancy Roizen, Simone Cezar, Mari Sautter, Jack Remington, Paul Meier, Rima Mcleod, Toxoplasmosis Study Group
published September 2008
Full Text | Journal Format-PDF (10062 KB)
Supplemental Figure 1. Occurrences of new toxoplasmic chorioretinal lesions: Numbers and locations by time of visit for each patient. Each open bar represents a patient, and each black vertical line represents a routine evaluation in Chicago. The length of the bar indicates the patient's current age. The number to the left of the bar is the number assigned to present that patient. Red vertical line denotes time of occurrence of new central lesions, and blue denotes time of occurrence of new peripheral lesions. R = right eye; L = left eye. Number within the parentheses is the number of new lesions found in that eye at that specific location of the retina at that visit. If a number appears to the right of an open bar, it refers to the last visit and is placed outside the bar so that the numbers are more easily read. One asterisk after R or L indicates a peripapillary lesion, and two after R or L asterisks indicate both macular and peripapillary lesion. Three asterisks after R or L indicate that the new lesions were active lesions. Yellow diamond indicates age of diagnosis prior to visit to NCCCTS (National Collaborative Chicago-Based Congenital Toxoplasmosis Study). Open diamond indicates recurrence prior to visit to NCCCTS. * within a bar indicates that at a patient's initial visit eye lesions were noted in only the right eye, + indicates that at the initial visit a patient has eye lesions in only the left eye, and ? indicates that at the initial visit the patient had eye lesions in both the right and left eye. (Top) The 28 patients in the cohort whose infections are most likely congenital. (Bottom) The 10 patients whose origin of infection is unknown.
Supplemental Figure 2. Clinical findings in children who develop new central toxoplasmic chorioretinal lesions (above the black horizontal line) compared with those who have not (below the black horizontal line). Thrombocytopenia: <180 000 (26- to 30-week prematurity), <150,000 (term); cerebrospinal fluid (CSF) protein elevation: >150 mg/dl (preterm), >170 mg/dl (term), >15 mg/dl (vent) and >40 mg/dl (lumbar) (>1 month old); CSF pleocytosis: >25/mm3 (preterm), >22/mm3 (term), >7/mm3 (>1 month old). Severity scores were formulated to provide uniform means to characterize impact of infection on vision: (0) normal vision, no lesion; (1) normal vision, nonmacular lesions; (2) normal vision, macular lesions; (3) impaired vision, nonmacular lesions; (4) impaired vision, macular lesions; (4.5) impaired vision, inability to view posterior because of cataracts or another eitiology; and (5) no observable light perception (retinal detachment and grossly abnormal electroretinogram). a = mild ventricular dilatation; * = earlier scans not available for review at time of publication; ** = child had magnetic resonance imaging (MRI) only; NL = pineal calcification, normal for age; ? = questionable calcification.

Expression of Vasohibin, an Antiangiogenic Factor, in Human Choroidal Neovascular Membranes
Ryosuke Wakusawa, Toshiaki Abe, Hajime Sato, Madoka Yoshida, Hiroshi Kunikata, Yasufumi Sato, Kohji Nishida
published August 2008
Full Text | Journal Format-PDF (1807 KB)
Supplemental Figure. Immunohistochemistry demonstrated vasohibin was expressed on a part of endothelial cells of choroidal vessels, retinal vessels, and retinal pigment epithelial (RPE) cells. Arrows indicate retinal or choroidal vessels and arrowheads for RPE layer. These regions are positive for vasohibin. A 8-week-old, Male Institute of Cancer Research (ICR) mice was used (original magnification, ×200). After anesthesia with ketamine hydrochloride (100 mg/kg body weight) the mice were killed. The eyes were enucleated and fixed in 4% formalin overnight at 4 C. They were cryoprotected in 10% to 20% sucrose- phosphate buffered saline (PBS) and then sectioned (10 µm). Immunohistochemical staining for vashohibin was performed using the horseradish peroxidase (HRP) method. All steps were performed at room temperature unless otherwise stated. Briefly, sections were treated with 3% hydrogen peroxide to block endogenous peroxidase activity. After blocking with 1% bovine serum albumin in PBS for 30 minutes, rabbit polyclonal antibodies against vasohibin (1:400; made by Watanabe and associates) were applied to the sections overnight at 4 C. The following morning, the sections were incubated in HRP-conjugated anti-rabbit IgG antibody overnight at 4 C. Brown chromogen diaminobenzidine was used for all sections. Nuclei were stained with methylgreen. The sections were washed three times with PBS between each step. For control, preimmune rabbit IgG was used instead of the primary antibody. Sections were examined under a standard light microscope. All treatments of the animals conformed to the ARVO Statement for the Use of Animals in Ophthalmic and Vision Research.

A Systematic Literature Review of Surgical Interventions for Limbal Stem Cell Deficiency in Humans
Paul A. Cauchi, Ghee S. Ang, Augusto Azuara-Blanco, Jennifer M. Burr
published August 2008
Full Text | Journal Format-PDF (487 KB)
Supplemental Table. Checklist for Quality Assessment of Case Series Studies on Intervention

Surgical Strategies for Fornix Reconstruction Based on Symblepharon Severity
Ahmad Kheirkhah, Gabriela Blanco, Victoria Casas, Yasutaka Hayashida, Vadrevu K. Raju, Scheffer C.G. Tseng
published August 2008
Full Text | Journal Format-PDF (5508 KB)
Supplemental Table. Clinical Characteristics, Surgical Procedures, and Outcomes in Eyes with Various Grades of Symblepharon

Ahmed Valve Implantation with Adjunctive Mitomycin C and 5-Fluorouracil: Long-term Outcomes
Jorge A. Alvarado, David A. Hollander, Richard P. Juster, Lillian C. Lee
published August 2008
Full Text | Journal Format-PDF (701 KB)
Supplemental Figure. Slit-lamp photographs taken one month postimplantation of an Ahmed valve with adjunctive antimetabolites and modified technique technique in which the tube was placed through the ciliary body into posterior chamber (PC) sulcus and across a peripheral iridectomy (PI) into the anterior chamber (AC). (Top left) Slit-lamp photograph is shown demonstrating tube extending through a PI into the AC. (Top right) Photograph showing the superotemporal quadrant demonstrating the intrascleral passage of the tube and the absence of any "bleb." (Bottom) Higher-magnification photograph showing the tube from the Ahmed valve, demonstrating the tube extending from the ciliary body across the PI into the AC.

Clinical Characteristics of Posterior Staphyloma in Eyes with Pathologic Myopia
Huang Wei Hsiang, Kyoko Ohno-Matsui, Noriaki Shimada, Kengo Hayashi, Muka Moriyama, Takeshi Yoshida, Takashi Tokoro, Manabu Mochizuki
published July 2008
Full Text | Journal Format-PDF (1123 KB)
Supplemental Table 1. The Relationship Between Grades of Myopic Degeneration and Grade of Posterior Staphyloma in Group 1
Supplemental Table 2. The Relationship between Grades of Myopic Degeneration and Grade of Posterior Staphyloma in Group 2

Comparison of Face-Down and Seated Position After Idiopathic Macular Hole Surgery: A Randomized Clinical Trial
Alexandre Guillaubey, Laure Malvitte, Pierre Olivier Lafontaine, Nicolas Jay, Isabelle Hubert, Alain Bron, Jean Paul Berrod, Catherine Creuzot-Garcher
published July 2008
Full Text | Journal Format-PDF (2198 KB)
Supplemental Figure. (Top) Face-down position (Patients were asked to keep this position intermittently for at least eight hours a day). (Bottom) Seated position (Patients were only asked not to look up after the surgery).

Suture-Assisted vs Forceps-Assisted Insertion of the Donor Lenticula during Descemet Stripping Automated Endothelial Keratoplasty
Igor Kaiserman, Irit Bahar, Penny McAllum, Allan R. Slomovic, David S. Rootman
published June 2008
Full Text | Journal Format-PDF (2773 KB)
Supplementary videos
Video 1
Video 2

Comparative Therapy Evaluation of Intravitreal Bevacizumab and Triamcinolone Acetonide on Persistent Diffuse Diabetic Macular Edema
Masahiko Shimura, Toru Nakazawa, Kanako Yasuda, Takashi Shiono, Tomohiro Iida, Taiji Sakamoto, Kohji Nishida
published May 2008
Full Text | Journal Format-PDF (1215 KB)
Supplemental Figure. (Case 14) A 68-year-old female with a nine year history of diabetes visited the outpatient clinic in NTT East Japan Hospital for bilateral visual disturbance. Her best-corrected logMAR visual acuity (VA) was 0.5 in each eye. Fluorescein angiography (1) and OCT findings (2, 3) revealed bilateral and symmetrical DME at the initial visit in right (Top left) and left (Top right) eyes, zero weeks. Foveal thickness (FT) was 583 µm in the right eye and 542 µm in the left. Intraocular pressure (IOP) was 17 mm Hg in each eye. 1.25 mg / 0.05 ml of bevacizumab was injected into the vitreous cavity in the right eye (Bottom left) and 4 mg / 0.1 ml of triamcinolone acetonide (TA) was injected in the left (Bottom right). In the bevacizumab-injected (right) eye, one week after the injection (1w), FT had decreased to 241 µm and VA had improved to 0.2 (4). Subsequently, FT had increased to 435 µm and VA had decreased to 0.5 at four weeks (4w), and finally at 24 weeks (24w), FT and VA had returned to the initial levels of 564 µm and 0.6 (5, 6). During the clinical course, IOP was 16 mm Hg at one week, 18 mm Hg at four weeks, and 19 mm Hg at 24 weeks. In contrast, after the injection, FT and VA in the left (TA-injected) eye improved 279 µm and 0.2. Then, FT and VA in the left eye were kept with 319 µm and 0.3 at four weeks, respectively. Finally, FT and VA were kept at 320 µm and 0.3 at 24 weeks. During the clinical course, IOP was 17 mm Hg at one week, 16 mm Hg at four weeks, and 17 mm Hg at 24 weeks, respectively.

Ranibizumab Combined With Verteporfin Photodynamic Therapy in Neovascular Age-related Macular Degeneration (FOCUS): Year 2 Results
Andrew N. Antoszyk, Lisa Tuomi, Carol Y. Chung, Angele Singh, FOCUS Study Group
published May 2008
Full Text | Journal Format-PDF (925 KB)
The FOCUS Study Group List

Retinal Thickness on Stratus Optical Coherence Tomography in People with Diabetes and Minimal or No Diabetic Retinopathy
Neil M. Bressler, Allison R. Edwards, Andrew N. Antoszyk, Roy W. Beck, David J. Browning, Antonio P. Ciardella, Ronald P. Danis, Michael J. Elman, Scott M. Friedman, Adam R. Glassman, Jeffrey G. Gross, Helen K. Li, Timothy J. Murtha, Thomas W. Stone, Jennifer K. Sun, Diabetic Retinopathy Clinical Research Network
published May 2008
Full Text | Journal Format-PDF (177 KB)
The Diabetic Retinopathy Clinical Research Network

Seasonal Variations in the Occurrence of Retinal Vein Occlusion: A Five-Year Nationwide Population-Based Study from Taiwan
Jau-Der Ho, Ching-Yao Tsai, Shiow-Wen Liou, Ray Jui-Fang Tsai, and Herng-Ching Lin
published April 2008
Full Text | Journal Format-PDF (853 KB)
Supplemental Figure 1. Monthly rates of retinal vein occlusion attacks (per 100,000) and monthly average ambient temperature in Taiwan, from 1999 to 2003.
Supplemental Figure 2. The number of monthly outpatient/emergency visits (in millions, for both ophthalmic and nonophthalmic diseases) in Taiwan, from 1999 to 2003.

Variability of Stereoacuity in Intermittent Exotropia
Sarah R. Hatt, Brian G. Mohney, David A. Leske, Jonathan M. Holmes
published March 2008
Full Text | Journal Format-PDF (133 KB)
Supplemental Table 1. Frisby Davis Distance and Distance Randot Stereoacuity Measured over One Day in Children with Intermittent Exotropia
Supplemental Table 2. Near Frisby and Preschool Randot Stereoacuity Measured over One Day in Children with Intermittent Exotropia

A Panel Assessment of Glaucoma Management: Modification of Existing RAND-like Methodology for Consensus in Ophthalmology. Part I: Methodology and Design
M. Roy Wilson, Paul P. Lee, Robert N. Weinreb, Brian L. Lee, Kuldev Singh
published March 2008
Full Text | Journal Format-PDF (507 KB)
Supplemental Appendix A: Polling Statements
Supplemental Appendix B: Graded Articles — Medical Therapy
Supplemental Appendix C: Articles Referenced in Synthesis of the Literature

A Panel Assessment of Glaucoma Management: Modification of Existing RAND-like Methodology for Consensus in Ophthalmology. Part II: Results and Interpretation
Kuldev Singh, Brian L. Lee, M. Roy Wilson
published March 2008
Full Text | Journal Format-PDF (479 KB)
Supplemental Appendix. The Modified-RAND Method for Assessing Glaucoma Therapy: Post-Meeting Polling Results

Lysyl Oxidase-like 1 Polymorphisms and Exfoliation Syndrome in the Japanese Population
Hisako Hayashi, Norimoto Gotoh, Yoshiki Ueda, Hideo Nakanishi, Nagahisa Yoshimura
published March 2008
Full Text | Journal Format-PDF (275 KB)
Supplemental Table. Polymorphisms and Exfoliation Syndrome: Genotype Counts for Single-Nucleotide Polymorphisms rs1048661 and rs3825942 in the Lysyl Oxidase-like 1 (LOXL1) Gene

Bilateral Acanthamoeba Keratitis
Kirk R. Wilhelmus, Dan B. Jones, Alice Y. Matoba, M. Bowes Hamill, Stephen C. Pflugfelder, Mitchell P. Weikert
published February 2008
Full Text | Journal Format-PDF (768 KB)
Supplemental Figure. Bilateral Acanthamoeba keratitis associated with daily-wear soft contact lenses affecting right eye (Top right) and left eye (Top left). Six months later, after antiamoebic therapy, corneal inflammation has resolved with minimal opacification of right eye (Bottom left) and left eye (Bottom right).

Randomized, Double-Masked, Sham-Controlled Trial of Ranibizumab for Neovascular Age-related Macular Degeneration: PIER Study Year 1
Carl D. Regillo, David M. Brown, Prema Abraham, Huibin Yue, Tsontcho Ianchulev, Susan Schneider, Naveed Shams, The PIER Study Group
published February 2008
Full Text | Journal Format-PDF (856 KB)
Supplemental Table A. Eligibility Criteria for PIER Study
Supplemental Table B-1. Criteria for Serious (Sight-Threatening) Ocular Adverse Events
Supplemental Table B-2. Grading Scales for Flare/Cells
Supplemental Table B-3. Grading Scale for Vitreous Cells
Supplemental Table C. Subject Disposition

Management of Canalicular Lacerations: Epidemiological Aspects and Experience with Mini-Monoka Monocanalicular Stent
Milind N. Naik, Anagha Kelapure, Suryasnata Rath, Santosh G. Honavar
published February 2008
Full Text | Journal Format-PDF (1576 KB)
Supplementary Video

Characteristics of Untreated AIDS-related Cytomegalovirus Retinitis. I. Findings before the Era of Highly Active Antiretroviral Therapy (1988 to 1994)
Gary N. Holland, Jean D. Vaudaux, Samuel M. Jeng, Fei Yu, David T. Goldenberg, Ina-Caren Folz, William G. Cumberland, Colin A. McCannel, Craig J. Helm, W. David Hardy, UCLA CMV Retinitis Study Group
published January 2008
Full Text | Journal Format-PDF (864 KB)
Supplement

Characteristics of Untreated AIDS-related Cytomegalovirus Retinitis. II. Findings in the Era of Highly Active Antiretroviral Therapy (1997 to 2000)
Gary N. Holland, Jean D. Vaudaux, Kevin M. Shiramizu, Fei Yu, David T. Goldenberg, Anurag Gupta, Margrit Carlson, Russell W. Read, Roger D. Novack, Baruch D. Kuppermann, Southern California HIV/Eye Consortium
published January 2008
Full Text | Journal Format-PDF (1815 KB)
Appendix

The Predictive Value of Patient and Eye Characteristics on the Course of Subclinical Diabetic Macular Edema
David J. Browning, Christina M. Fraser
published January 2008
Full Text | Journal Format-PDF (572 KB)
Supplemental Table. Optical Coherence Tomography and Visual Acuity Data at Specified Follow-Up Times

Leber Congenital Amaurosis-A Model for Efficient Genetic Testing of Heterogeneous Disorders: LXIV Edward Jackson Memorial Lecture
Edwin M. Stone
published December 2007
Full Text | Journal Format-PDF (4044 KB)
Supplemental Material on detailed methods for single-strand conformational polymorphism analysis, automated dna sequencing, the allele specific ligation assay, quantitative PCR analysis, and high density SNP genotyping

Ranibizumab for Predominantly Classic Neovascular Age-related Macular Degeneration: Subgroup Analysis of First-year ANCHOR Results
Peter K. Kaiser, David M. Brown, Kang Zhang, Henry L. Hudson, Frank G. Holz, Howard Shapiro, Susan Schneider, Nisha R. Acharya
published December 2007
Full Text | Journal Format-PDF (1117 KB)
The ANCHOR Study Group
Supplemental Table. Patient Disposition in ANCHOR Trial

Verteporfin Therapy of Subfoveal Occult Choroidal Neovascularization in AMD Using Delayed Light Application: One-year Results of the VALIO Study
Philip J. Rosenfeld, David S. Boyer, Neil M. Bressler, Gary Fish, W. Sanderson Grizzard, Yong Hao, Peter Hnik, Henry L. Hudson, Lawrence Singerman, Jason S. Slakter, VALIO Study Group
published December 2007
Full Text | Journal Format-PDF (162 KB)
Supplemental Protocol VALIO Study Design
Supplemental Figure. Profile of participants receiving treatment and completing follow-up (at least a protocol visual acuity assessment) through 12 months.
Supplemental Table 1. Principal Baseline Characteristics of Eyes Treated with Standard Light or Delayed Light in the VALIO Study
Supplemental Table 2. Summary of Adverse Events Judged to be Clinically Relevant over the Course of 12 Months in the VALIO Study

LOXL1 Mutations Are Associated with Exfoliation Syndrome in Patients from the Midwestern United States
John H. Fingert, Wallace L.M. Alward, Young H. Kwon, Kai Wang, Luan M. Streb, Val C. Sheffield, Edwin M. Stone
published December 2007
Full Text | Journal Format-PDF (57 KB)
Supplemental Table. LOX1 Genotypes in Patients with Exfoliation Syndrome and in Controls

Histopathologic and Immunologic Aspects of AlphaCor Artificial Corneal Failure
Marco Coassin, Cheng Zhang, W. Richard Green, James V. Aquavella, Esen K. Akpek
published November 2007
Full Text | Journal Format-PDF (6463 KB)
Supplemental Figure 1.
Supplemental Figure 2.
Supplemental Figure 3.
Supplemental Figure 4.

Posterior Iris Fixation of the Iris-Claw Intraocular Lens Implantation through a Scleral Tunnel Incision
Mehmet Baykara, Hikmet Ozcetin, Sami Yilmaz, Özgur Bülent Timuçin
published October 2007
Full Text | Journal Format-PDF (1787 KB)
Supplementary Videos
Video 1
Video 2
Video 3
Video 4
Video 5
Video 6

The Long-term Effect of Vitreous Presentation During Extracapsular Cataract Surgery on Postoperative Visual Acuity
Gaster RN, Collins JF
published August 2007
Full Text | Journal Format-PDF (473 KB)
Appendix The VA Cooperative Cataract Study Group

Comparison of Autologous Serum and Umbilical Cord Serum Eye Drops for Dry Eye Syndrome
Yoon KC, Heo H, Im SK, You IC, Kim YH, Park YG
published July 2007
Full Text | Journal Format-PDF (2734 KB)
Supplemental Table. Changes in Symptoms and Signs after Autologous Serum or Umbilical Cord Serum Treatment in Patients without Sjögren Syndrome

Comparison of Fibrin Glue and Sutures for Conjunctival Closure in Pars Plana Vitrectomy
Mentens R, Stalmans P
published July 2007
Full Text | Journal Format-PDF (1032 KB)
Supplementary data Video 1.

Ectatic Disorders Associated With a Claw-shaped Pattern on Corneal Topography
Lee BW, Jurkunas UV, Harissi-Dagher M, Poothullil AM, Tobaigy FM, Azar DT
published July 2007
Full Text | Journal Format-PDF (1487 KB)
Supplemental Figure 1. Claw-shaped patterns on Orbscan II (Bausch & Lomb, Rochester, New York, USA; hardware version 2GOT4.0 and software version is 31257SP3) mean keratometric axial power maps of representative patients with pellucid marginal degeneration [PMD] (a-c) with peripheral corneal thinning in an arcuate or crescenteric pattern on slit-lamp photography (d). Claw-shaped patterns were also seen in representative patients with keratoconus (e-g) with central corneal thinning on slit-lamp photography (h), and in patients with postoperative ectasia (i-k). The slit-lamp photos shown in (d) and (h) were taken from patients whose topographic maps are shown in (c) and (g), respectively.
Supplemental Figure 2. Orbscan II topographic data of representative patient with pellucid marginal degeneration (PMD). Anterior elevation float is depicted in the upper left corner, posterior elevation float in the upper right, mean keratometric axial power map in the lower left (showing superior flattening and horizonatal steepening), and pachymetry map in the lower right. Note the thin pachymetry in the inferior corneal periphery.
Supplemental Figure 3. Orbscan II topographic data of representative patient with keratoconus. Anterior elevation float is depicted in the upper left corner, posterior elevation float in the upper right, mean keratometric axial power map in the lower left (showing claw-like pattern in an oblique meridian), and pachymetry map in the lower right.

Biometry and Formula Accuracy With Intraocular Lenses Used for Cataract Surgery in Extreme Hyperopia
MacLaren RE, Natkunarajah M, Riaz Y, Bourne RRA, Restori M, Allan BDS
published June 2007
Full Text | Journal Format-PDF (1558 KB)
Supplemental Table 4. Pre-Existing Ocular Morbidity of Hyperopic Eyes Undergoing Cataract Surgery
Supplemental Table 5. Complications Arising in Hyperopic Eyes Undergoing Cataract Surgery

Clinical Characteristics and Outcome of Candida Keratitis
Sun RL, Jones DB, Wilhelmus KR
published June 2007
Full Text | Journal Format-PDF (574 KB)
Supplemental Figure. Visual acuity of eyes with Candida keratitis upon presentation compared to visual acuity at follow-up. Visual outcome of 20/60 or better occurred in all six eyes with initial visual acuity of at least 20/60, but in only five (24%) of eyes with worse initial visual acuity (P = .002). Reasons for poor visual outcome included corneal opacification or graft failure, enucleation or evisceration (2), and retinal detachment (1).

Visualization of Aqueous Shunt Position and Patency Using Anterior Segment Optical Coherence Tomography
Sarodia U, Sharkawi E, Hau S, Barton K
published June 2007
Full Text | Journal Format-PDF (1501 KB)
Supplemental Case 4. A 41-year-old White male who had been implanted in the right eye with a Baerveldt 350 implant for angle closure glaucoma secondary to severe trauma, had previously also been implanted with an intraocular lens and an aniridic iris implant. A penetrating keratoplasty (PK) performed for corneal oedema failed after six months and was repeated. The aniridic implant was implicated and therefore removed. Rejection of the second PK precluded visualisation of the shunt which was suspected to have contributed to corneal failure. The intraocular pressure was normal. Anterior segment (AS-OCT) (Figure 4S, Left and Right) clearly demonstrated that the shunt was positioned well away from corneal endothelium.
Supplemental Figure 4. AS-OCT demonstrating good position and normal patency of the shunt aperture (arrow) in an eye with a failed penetrating keratoplasty (PK) where mechanical contact between tube and corneal endothelium could not be excluded on slit-lamp examination. The intrascleral course of the shunt can also be clearly seen.

Abnormal Foveal Avascular Zone in Nanophthalmos
Walsh MK, Goldberg MF
published June 2007
Full Text | Journal Format-PDF (2289 KB)
Supplemental Figure 1. Fluorescein angiograms (FAs) of nanophthalmic patients, each of which shows a small, rudimentary foveal avascular zone (FAZ; image on right of each pair = 3x magnification of fovea). The top left images are from a normal 28-year-old female with a normal FAZ. Imaging of the left eye of nanophthalmic Patient 1 reveals a small, rudimentary FAZ and occult CNV (Top right). Nanophthalmic Patient 2?s FA shows a small, rudimentary FAZ, juxtafoveal window defect (fades late without leakage), and superior choroidal folds (2nd row left). Patient 2?s left eye has a small, rudimentary FAZ and choroidal folds (2nd row right, images). The FA from nanophthalmic Patient 3 shows a small, rudimentary FAZ and window defects OS (fade late without leakage; 3rd row left). Nanophthalmic Patient 4 also has a small, rudimentary FAZ OS (3rd row right, images).
Supplemental Figure 2. Foveal ocular coherence tomography (OCT) scans, which show lack of normal foveal contours in nanophthalmic patients. The top left image is from a normal 37-year-old male showing a normal foveal pit/contour with mean subfield retinal thicknesses for this patient (circular diagram) and color code for percentiles in the normal population distribution. Patient 2 had a thickened macula and lack of a foveal pit OD both prior to (top row right; OCT) and after development of a post-operative choroidal effusion (2nd row left, OCT) and OS (2nd row right). The OCT of Patient 3 also reveals a thickened macula and lack of a foveal pit OS (3rd row left). Patient 4 has a macula of normal thickness but also lacks a foveal pit OD (3rd row right).

Visual Performance Using a Retinal Prosthesis in Three Subjects With Retinitis Pigmentosa
Yanai D, Weiland JD, Mahadevappa M, Greenberg RJ, Fine I, Humayun MS
published May 2007
Full Text | Journal Format-PDF (756 KB)
Supplemental Figure. How the visual world was mapped onto individual electrodes for both multi- and single pixel testing in retinal prosthesis implant subjects. The empty circles represent the "natural" representation of each electrode in the subject?s visual field (i.e., upper electrodes represent those that were inferior on the retina. The electrodes on the right represent temporal electrodes in left eye-implanted subjects, and nasal electrodes in right eye-implanted patients). The camera and video processing unit reduces the visual field to 16 camera pixels. The grid inside each electrode shows which camera pixel was mapped onto that electrode. If no squares in the grid are highlighted, then this electrode was not used in camera testing for reasons described in the text. Light gray squares represent mappings where stimulation amplitudes used for the camera were sub-threshold when that electrode was stimulated in isolation. White squares represent mappings where stimulation amplitudes were above threshold when that electrode was stimulated in isolation.

Vertical Corneal Striae in Families with Autosomal Dominant Hearing Loss: DFNA9/COCH
Bischoff AMLC, Pauw RJ, Huygen PLM, Aandekerk AL, Kremer H, Cremers CWRJ, Cruysberg JRM
published May 2007
Full Text | Journal Format-PDF (1494 KB)
Appendix 1 Results of COCH Mutation Analysis, Corneal Findings and Ophthalmologic Examination in Four DFNA9 Families Family 1
Appendix 2 Results of COCH Mutation Analysis, Corneal Findings and Ophthalmologic Examination in Four DFNA9 Families Family 2
Appendix 3 Results of COCH Mutation Analysis, Corneal Findings and Ophthalmologic Examination in Four DFNA9 Families Family 3
Appendix 4 Results of COCH Mutation Analysis, Corneal Findings and Ophthalmologic Examination in Four DFNA9 Families Family 4

Rates of Glaucoma Medication Utilization Among Older Adults with Suspected Glaucoma, 1992 to 2002
Stein JD, Sloan FA, Lee PP
published May 2007
Full Text | Journal Format-PDF (113 KB)
Supplemental Appendix 1 Additional details about the methods
Supplemental Appendix 2 Additional results

Microrips of the Retinal Pigment Epithelium in Polypoidal Choroidal Vasculopathy
Musashi K, Tsujikawa A, Hirami Y, Otani A, Yodoi Y, Tamura H, Yoshimura N
published May 2007
Full Text | Journal Format-PDF (1119 KB)
Supplemental Figure A 78-year-old man (Patient 1) with polypoidal choroidal vasculopathy in the right eye had been followed at our clinic for 10 years. Visual acuity (VA) in the right eye was 20/1000. (Top left) A reddish-orange nodule (arrow) with a large serous pigment epithelial detachment (PED) (arrowheads) is present in the right eye. (Top right) Indocyanine green angiography (IA) shows a branching vascular network (arrowheads) terminating in polypoidal lesions (arrows). (2nd row, left) Fluorescein angiography (FA) shows no microrips of the retinal pigment epithelium (RPE) on this examination. He underwent photodynamic therapy (PDT) in the right eye. Yellow dotted circle shows a laser irradiation spot. (2nd row, right) PDT was not effective and repeat IA done three months after treatment shows persistent polypoidal lesions and enlargement of the PED (arrowheads). (3rd row, left) Three months after treatment, FA reveals a microrip of the RPE (arrow) at the upper margin of the enlarged serous PED, with an area of pinpoint leakage from the RPE seen in the early phase. (3rd row, right) In the late phase of FA, leakage from the RPE (arrow) is increased and pooling is seen in the subretinal space. He underwent a second session of PDT in the right eye (yellow dotted circle). (Bottom left) Following this second PDT, the PED decreased and FA showed complete resolution of the microrip previously present in the RPE.

Choroidal Folds in Vogt-Koyanagi-Harada Disease
Wu W, Wen F, Huang S, Luo G, Wu D
published May 2007
Full Text | Journal Format-PDF (1647 KB)
Supplemental Figure 2 Fluorescein angiogram (FA) at the intermediate stage of the same eye. The choroidal folds show hypofluorescent bands (black arrows) which are much wider than the large retinal vessels in the position of optic disk. Most folds radiate from the optic disk to the periphery. One long choroidal fold passes through the macular area vertically. The optic disk shows hyperfluorescence and no obvious retinal leakage occur.
Supplemental Figure 3 Indocyanine green angiogram (ICGA) at the early stage of the same eye. The choroidal folds also show hypofluorescent bands (black arrows) which are obviously thinner than those on fluorescein angiogram (FA). The hypofluorescent bands corresponding to the choroidal fold which passes through the macular area vertically is much clearer than others.
Supplemental Figure 4 Indocyanine green angiogram (ICGA) at the intermediate stage of the same eye. The choroidal folds still show hypofluorescent bands (black arrows) and become much clearer with the reinforcement of the choroidal background fluorescence.
Supplemental Figure 5 Indocyanine green angiogram (ICGA) at the late stage of the same eye. The hypofluorescent bands at the intermediate stage turn hyperfluorescence or isofluorescence.

Peripapillary Schisis in Glaucoma Patients With Narrow Angles and Increased Intraocular Pressure
Kahook MY, Noecker RJ, Ishikawa H, Wollstein G, Kagemann L, Wojtkowski M, Duker JS, Srinivasan VJ, Fujimoto JG, Schuman JS
published April 2007
Full Text | Journal Format-PDF (1884 KB)
Supplementary Material
Video 1 (5604 KB)
Video 2 (5699 KB)

A Portable Visual Acuity Device Used in Diabetic Retinal Screening
Kehler LAF, Kehler KB, Merin LM, Tsai JC
published March 2007
Full Text | Journal Format-PDF (301 KB)
Supplemental Table. Demographics and Total-Correct Scores for Visual Acuity Testing Using the Optec 800 Vision Screener and the Early Treatment Diabetic Retinopathy Study Chart

Intravitreal Bevacizumab for Idiopathic Choroidal Neovascularization After Previous Injection With Posterior Subtenon Triamcinolone
Gomi F, Nishida K, Oshima Y, Sakaguchi H, Sawa M, Tsujikawa M, Tano Y
published March 2007
Full Text | Journal Format-PDF (3087 KB)
Figure. The optical coherence tomography (OCT) scans before and after bevacizumab injection for idiopathic CNV. (Top left) The macular edema at the choroidal neovascularization (CNV) from patient 2 was apparent before bevacizumab injection. (Top right) The resolution of the edema and the contracted CNV was seen three months after injection. The macular edema observed before bevacizumab injection from patient 9 (Bottom left) reduced apparently three months after one injection (Bottom right).
Figure. Fluorescein angiography of idiopathic choroidal neovascularization (CNV) treated by intravitreal injection of bevacizumab after subtenon triamcinolone. (Top left) Leakage from small idiopathic CNV in patient 2 was seen at baseline. (Top center) Despite subtenon triamcinolone injection, CNV enlarged, and leakage increased until bevacizumab injection. (Top right) Three months after bevacizumab injection, the lesion shrank and leakage stopped. Severe leakage from idiopathic CNV in patient 8 (Bottom left) was not stopped by triamcinolone at three months after treatment (Bottom middle). (Bottom right) Three months after intravitreal bevacizumab injection, eccentric fibrotic scar after contraction of original subfoveal CNV is seen.

Progression of Geographic Atrophy and Impact of Fundus Autofluorescence Patterns in Age-related Macular Degeneration
Holz FG, Bindewald-Wittich A, Fleckenstein M, Dreyhaupt J, Scholl HPN, Schmitz-Valckenberg S, Fam-Study Group
published March 2007
Full Text | Journal Format-PDF (1201 KB)
Appendix Centers and members participating in the Fundus Autofluorescence in Age-Related Macular Degeneration (FAM) Study

Efficacy of Different Intraocular Lens Materials and Optic Edge Designs in Preventing Posterior Capsular Opacification: A Meta-Analysis
Cheng JW, Wei RL, Cai JP, Xi GL, Zhu H, Li Y, Ma XY
published March 2007
Full Text | Journal Format-PDF (896 KB)
Appendix The following is the quality scoring system used in this meta-analysis. The score for each trial was reported as a percentage of maximum possible score of 10 (Table 1 in text).

Discordance Between Subjective Perimetric Visual Fields and Objective Multifocal Visual Evoked Potential-Determined Visual Fields in Patients With Hemianopsia
Watanabe K, Shinoda K, Kimura I, Mashima Y, Oguchi Y, Ohde H
published February 2007
Full Text | Journal Format-PDF (3252KB)
Supplemental Table 1: Multifocal Visual Evoked Potential Parameters in the Right Eye of Normal Subjects (n = 10)
Supplemental Table 2: Multifocal Visual Evoked Potential Parameters in the Right Eye of Normal Subjects (n = 10)
Supplemental Figure 1: Element number and location of each darts pattern. Element number and location of each darts pattern are indicated.
Supplemental Figure 2: The relationship of each darts sector with stimulated visual field is shown. The size of each sector was cortically-scaled with eccentricity to stimulate approximately equal areas of the cortical (striate) surface.

A Self-stabilizing Lens Ring for 25-Gauge Vitrectomy Surgery
Chong LP, McCormick M, DeBoer C, Barnes A
published February 2007
Full Text | Journal Format-PDF (269KB)
Supplemental Video Online video (10.5 MB)

Treatment Outcomes in the Tube Versus Trabeculectomy Study After One Year of Follow-up
Gedde SJ, Schiffman JC, Feuer WJ, Herndon LW, Brandt JD, Budenz DL, The Tube Versus Trabeculectomy Study Group
published January 2007
Full Text | Journal Format-PDF (579KB)
List of Investigators: Participating Centers and Committees in the Tube Versus Trabeculectomy Study

Surgical Complications in the Tube Versus Trabeculectomy Study During the First Year of Follow-up
Gedde SJ, Herndon LW, Brandt JD, Budenz DL, Feuer WJ, Schiffman JC, The Tube Versus Trabeculectomy Study Group
published January 2007
Full Text | Journal Format-PDF (366KB)
List of Investigators: Participating Centers and Committees in the Tube Versus Trabeculectomy Study

Radial Optic Neurotomy in Central Retinal Vein Occlusion: Comparison of Outcome in Younger vs Older Patients
Garcia-Arumi J, Boixadera A, Martinez-Castillo V, Montolio M, Verdugo A, Corcóstegui B
published January 2007
Full Text | Journal Format-PDF (6531KB)
Supplementary Figure 1S: Right eye of a 27-year-old woman, showing predominantly hemorrhagic central retinal vein occlusion (CRVO) (patient 10, group 1). (Top) Two-months postoperative retinal photograph. Postoperative retinal photograph two months after vitrectomy and radial optic neurotomy (RON). Several retinal hemorrhages are still evident. A retinochoroidal anastomosis is already present at the level of the RON. (Bottom). Four-months postoperative retinal photograph. Postoperative retinal photograph four months after vitrectomy and RON. Retinal hemorrhages have markedly decreased. Changes in the macular retinal pigment epithelium are observed.
Supplementary Figure 2S: Left eye of a 72-year-old man with central retinal vein occlusion (CRVO) (patient 7, group 2). (Top) Two-months postoperative retinal photograph. Postoperative retinal photograph two months after vitrectomy and radial optic neurotomy (RON). There is already a marked reduction in retinal hemorrhages and lipid exudates have been partially reabsorbed. A retinochoroidal anastomosis is observed and there are retinal pigment epithelium changes at the macula.
(Bottom) Four-months postoperative retinal photograph. Postoperative retinal photograph four months after vitrectomy and RON. Few retinal hemorrhages remain and some lipid exudate can still be seen.

Self-Retaining 27-Gauge Transconjunctival Chandelier Endoillumination for Panoramic Viewing During Vitreous Surgery
Oshima Y, Awh CC, Tano Y
published January 2007
Full Text | Journal Format-PDF (4352KB)
Supplementary Figure: Intraoperative view of use of the 25-gauge light pipe and the 27-gauge chandelier endoilluminator in a patient with a retinal detachment complicated by a vitreous hemorrhage. (Top left) Intraoperative view under the 25-gauge light pipe endoilluminator. Only a small area of the vitreous opacity can be observed by spotlight illumination. (Top right) Intraoperative view under the 27-gauge chandelier endoilluminator in the same patient. Sufficient illumination was obtained to observe the entire area of vitreous opacity and the retina at the posterior pole. (Bottom left) Peripheral vitreous shaving under scleral depression performed with the surgeon?s left hand. A clear view of the transparent vitreous can be achieved using the 27-gauge chandelier endoilluminator. (Bottom right) Endolaser photocoagulation to the retinal breaks can be applied easily after fluid-air exchange under 27-gauge chandelier endoillumination.

A Novel OPA1 Mutation Responsible for Autosomal Dominant Optic Atrophy with High Frequency Hearing Loss in a Chinese Family
Chen S, Zhang Y, Wang Y, Li W, Huang S, Chu X, Wang L, Zhang M, Liu Z
published January 2007
Full Text | Journal Format-PDF (658KB)
Supplementary Figure 1S: Fundus photograph of the left eye of individual III:3. This individual has autosomal dominant optic atrophy, sensorineural hearing loss, and high myopia. The optic disk is tilted and pale in temporal side. There are lacquer cracks in the Bruch membrane and clumps of pigment are dispersed irregularly throughout a relatively depigmented macula.
Supplementary Figure 2S: Audiogram of individual III:3. This individual has optic atrophy, sensorineural hearing loss, and high myopia. Left panel indicates thresholds in the left ear, and right panel indicates the thresholds in the right ear. This pattern of hearing loss is consistent with sensorineural high frequency loss.

Introducing a New Computer-based Test for the Clinical Evaluation of Color Discrimination
Melamud A, Simpson E, Traboulsi EI
published December 2006
Full Text | Journal Format-PDF (1018KB)
Supplementary Figure: Computer monitor set up to present the Portal Color Sort Test (PCST). The monitor displays the first set of a series of 4 sets of trays that compose the test. In the first screen, the subject is presented with two trays (Top and Bottom) with a total of 11 colored circles. The subject is asked to move the 9 circles from the top tray to the bottom tray and arrange them in a logical order. The subject moves the colored circles manually by tapping the touch sensitive screen. The subject proceeds to the next set of trays by clicking the icons shown in the upper part of the monitor.

Vascular Endothelial Growth Factor Is a Critical Stimulus for Diabetic Macular Edema
Nguyen QD, Tatlipinar S, Shah SM, Haller JA, Quinlan E, Sung J, Zimmer-Galler I, Do DV, Campochiaro PA
published December 2006
Full Text | Journal Format-PDF (2652KB)
Supplementary Figure 1S: Excess macular volume measured by optical coherence tomography (OCT) in all patients at each study visit. Each bar represents the macular volume above the normal mean value of 6.94 mm3, which is set to 0. The arrows show intraocular injections of 0.5 mg of ranibizumab.
Supplementary Figure 2S: The mean excess macular volume for all 10 patients at each study visit. Each bar represents the mean value for excess macular volume for all patients at the designated study visit. The arrows show when intraocular injections of 0.5 mg of ranibizumab were administered. Compared to baseline, macular volume was reduced by 1.75 mm3 at the primary endpoint of the study, constituting elimination of 77% of the excess macular volume that had been present at baseline.

Trends in Cost of Major Eye Diseases to Medicare, 1991 to 2000
Salm M, Belsky D, Sloan FA
published December 2006
Full Text | Journal Format-PDF (723KB)
Supplementary Material: Appendix A. Diagnosis Codes Used to Identify Major Eye Diseases
Supplementary Material: Appendix B. Procedure Codes Used to Identify Major Eye Diseases
Supplementary Material: Appendix C. Device Codes Used to Identify Major Eye Diseases

Validation and Test Characteristics of a 10-Item Neuro-Ophthalmic Supplement to the NEI-VFQ-25
Raphael BA, Galetta KM, Jacobs DA, Markowitz CE, Liu GT, Nano-Schiavi ML, Galetta SL, Maguire MG, Mangione CM, Globe DR, Balcer LJ
published December 2006
Full Text | Journal Format-PDF (249KB)
Supplementary Material: Appendix. 10-Item Neuro-Ophthalmic Supplement to the NEI-VFQ-25

Retinal Pigment Epithelial Tear After Intravitreal Bevacizumab Injection
Shah CP, Hsu J, Garg SJ, Fischer DH, Kaiser R
published December 2006
Full Text | Journal Format-PDF (2346KB)
Supplementary Figure 1S: Color photos of retinal pigment epithelial (RPE) tear following intravitreal bevacizumab injection in Patient 1. Prior to treatment, there were retinal hemorrhages, subretinal fluid, and a pigment epithelial detachment (PED) (Top). After the third injection, the patient had a large RPE tear on a color photograph (Bottom).
Supplementary Figure 2S: Color photo of Patient 2 before intravitreal bevacizumab injection. Prior to treatment, there were intraretinal hemorrhages and a pigment epithelial detachment (PED).

Factors Associated With a Previous Diagnosis of Strabismus in a Population-based Sample of 12-Year-Old Australian Children
Robaei D, Kifley A, Mitchell P
published December 2006
Full Text | Journal Format-PDF (135KB)
Supplemental Table: Multivariate-adjusted Odds of Previous Strabismus Diagnosis in a Population of Predominantly 12-Year-old Australian Children

Wavefront Analysis and Contrast Sensitivity of Aspheric and Spherical Intraocular Lenses: A randomized prospective study
Rocha KM, Soriano ES, Chalita MR, Yamada AC, Bottós K, Bottós J, Morimoto L, Nosé W
published November 2006
Full Text | Journal Format-PDF (1495Kb)
Supplementary Material: Figure 1S. Wavefront analysis of a patient implanted with AcrySofNatural in right eye and AcrySofIQ in left eye.
Supplementary Material: Figure 2S. Wavefront analysis of a patient implanted with AMOSensar in right eye and AcrySofIQ in left eye.
Supplementary Material: Figure 3S. Wavefront analysis of a patient implanted with AcrySofIQ in right eye 1 and 3 months postoperative, showing trefoil 9 reduction.
Supplementary Material: Figure 4S. Wavefront analysis of a patient implanted with AcrySofNatural in right eye 1 and 3 months postoperative, showing trefoil 9 reduction.

Cannulation of the Suprachoroidal Space: A Novel Drug Delivery Methodology to the Posterior Segment
Olsen TW, Feng X, Wabner K, Conston SR, Sierra DH, Folden DV, Smith ME, Cameron JD
published November 2006
Full Text | Journal Format-PDF (7014Kb)
Supplemental Video Online video (77.9 MB)

A Novel His158Arg Mutation in TIMP3 Causes a Late-Onset Form of Sorsby Fundus Dystrophy
Lin RJ, Blumenkranz MS, Binkley J, Wu K, Vollrath D
published November 2006
Full Text | Journal Format-PDF (2787Kb)
Supplementary Material: Case Histories

Persistence of Cloquet's Canal in Normal Healthy Eyes
Kagemann L, Wollstein G, Ishikawa H, Gabriele ML, Srinivasan VJ, Wojtkowski M, Duker JS, Fujimoto JG, Schuman JS
published November 2006
Full Text | Journal Format-PDF (1595Kb)
Supplemental Video Supplemental Video (22.8 MB)

Topical Interferon Alfa-2b for the Treatment of Recalcitrant Ocular Surface Squamous Neoplasia
Holcombe DJ, Lee GA
published October 2006
Full Text | Journal Format-PDF (388Kb)
Supplementary Material: Figure 5. Recurrent dysplasia of the limbus recalcitrant to previous excision, topical mitomycin C (MMC) and two months of topical INF-α2b.
Supplementary Material: Figure 6. Regression of dysplasia of the limbus, two months following a further course of topical mitomycin C (MMC) after failure of topical INF-α2b.

Assessment of Axonal Degeneration Along the Human Visual Pathway Using Diffusion Trace Analysis
Ueki S, Fujii Y, Matsuzawa H, Takagi M, Abe H, Kwee IL, Nakada T
published October 2006
Full Text | Journal Format-PDF (508Kb)
Supplementary Material: Appendix. Diffusion tensor analysis

Ultrasonographic Characteristics and Treatment Outcomes of Surgery for Vitreous Hemorrhage in Idiopathic Polypoidal Choroidal Vasculopathy
Jalali S, Parra SL, Majji AB, Hussain N, Shah VA
published October 2006
Full Text | Journal Format-PDF (760Kb)
Supplementary Material: Supplemental case study
Supplementary Material: Figure 1S. Ultrasonography at presentation showed dispersed vitreous cavity echoes, elevated retinochoroidal complex (arrow) and hemorrhagic retinal detachment.
Supplementary Material: Figure 2S. Post-vitrectomy fundus photo (left) showing hemorrhagic retinal elevation just below the macula (arrow). Note yellowish-orange old sub-RPE blood (green arrow). FA-ICG A revealed multiple polypoidal hyperfluorescent choroidal lesions due to IPCV (Right).
Supplementary Material: Figure 3S. Post-vitrectomy Rhegmatogenous retinal detachment in an eye with IPCV. Note elevated retinal membrane spike with no underlying echoes but persistent choroidal thickening (arrow).

Progression of Choroidal Neovascularization Following Injection of Pegaptanib Sodium (Macugen) in Two Eyes With Neovascular Age-related Macular Degeneration
Williams AJ, Fekrat S
published October 2006
Full Text | Journal Format-PDF (172Kb)
Supplementary Material: Figure. Left eye. Fluorescein angiography demonstrates occult choroidal neovascularization (CNV). Early and late phase of the angiogram prior to intravitreal pegaptanib are shown.

Rubeosis and Anterior Segment Ischemia Associated With Systemic Cryoglobulinemia
Telander DG, Holland GN, Wax MB, Van Gelder RN
published October 2006
Full Text | Journal Format-PDF (169Kb)
Supplementary Material: Detailed case descriptions

Risk Factors for Five-Year Incident Age-related Macular Degeneration: The Reykjavik Eye Study
Arnarsson A, Sverrisson T, Stefánsson E, Sigurdsson H, Sasaki H, Sasaki K, Jonasson F
published September 2006
Full Text | Journal Format-PDF (135Kb)
Supplementary Material: Table. The Reykjavik Eye Study Items in the Questionnaire

Decreased Density of Corneal Basal Epithelium and Subbasal Corneal Nerve Bundle Changes in Patients with Diabetic Retinopathy
Chang PY, Carrel H, Huang JS, Wang IJ, Hou YC, Chen WL, Wang JY, Hu FR
published September 2006
Full Text | Journal Format-PDF (187Kb)
Supplementary Material: Figure 1
Supplementary Material: Figure 2

Third-Generation Optical Coherence Tomography Findings in Punctate Retinal Toxoplasmosis
Oréfice JL, Costa RA, Campos W, Calucci D, Scott IU, Oréfice F
published September 2006
Full Text | Journal Format-PDF (441Kb)
Supplementary Material: Table. Baseline Clinical Characteristics and Follow-up Evaluation in Patients With Punctate Retinal Toxoplasmosis

Contrast Sensitivity and Color Vision in HIV-infected Individuals Without Infectious Retinopathy
Kayur H. Shah, MD, Gary N. Holland, MD, Fei Yu, PhD, Mark Van Natta, MHS, Steven Nusinowitz, PhD
published August 2006
Full Text | Journal Format-PDF (403Kb)
Supplementary Material: TABLE 6. Contrast Sensitivity vs Color Vision for HIV-Infected Individuals with Normal Visual Acuity Using Age-Adjusted Normal Values

Melatonin Concentrations in Aqueous Humor of Glaucoma Patients
Christophe Chiquet, MD, PhD, Bruno Claustrat, PhD, Gilles Thuret, MD, PhD, Jocelyne Brun, PhD, Howard M. Cooper, PhD, Philippe Denis, MD, PhD
published August 2006
Full Text | Journal Format-PDF (160Kb)
Supplementary Material Table. Inclusion and Exclusion Criteria, Characteristics of Glaucoma Patients, RIA Technique

Autologous Translocation of the Choroid and Retinal Pigment Epithelium in Age-related Macular Degeneration
Antonia M. Joussen, MD, Florian M.A. Heussen, BS, Sandra Joeres, MD, Helene Llacer, MD, Beate Prinz, OD, Klaus Rohrschneider, MD, Kristel J.M. Maaijwee, MD, Jan van Meurs, MD, Bernd Kirchhof, MD
published July 2006

Full Text | Journal Format-PDF (160Kb)
Video 1: Online video (22 MB)

The Evaluation of Light Sensitivity in Benign Essential Blepharospasm
Wesley H. Adams, MD, Kathleen B. Digre, MD, Bhupendra C.K. Patel, MD, Richard L. Anderson, MD, Judith E.A. Warner, MD, Bradley J. Katz, MD, PhD
published July 2006
Full Text | Journal Format-PDF (417Kb)
Supplementary Material: Figure E1
Supplementary Material: Figure E2
Supplementary Material: Figure E3
Supplementary Material: Figure E4
Supplementary Material: Figure E5
Supplementary Material: Figure E6

Correctable and Non-Correctable Visual Impairment in a Population-Based Sample of 12-Year-Old Australian Children
Dana Robaei, MBBS, MPH, Son C. Huynh, MBBS, MMed, Annette Kifley, MBBS, MAppStat, Paul Mitchell, MD, PhD, FRANZCO
published July 2006
Full Text | Journal Format-PDF (52Kb)
Supplementary Material: Supplemental Table

Comparability of Cup and Disk Diameters Measured From Nonstereoscopic Digital and Stereoscopic Film Images
Andrew Ewen, BA, Kristine E. Lee, MS, Barbara E.K. Klein, MD, MPH, Ronald Klein, MD, MPH
published June 2006
Full Text | Journal Format-PDF (159Kb)
Supplemental Figure. The Top and Bottom figures describe the comparability of the measures of optic disk and optic cup diameters from the dilated and undilated images from the digital camera. Paired difference in measures plotted against the average of the pair. Dashed lines represent mean and 2 standard deviations for the difference. The zero value on the y-axis indicates that there is no difference between the measures taken from the paired images; values greater than zero indicate that measures from the dilated images were greater than those from the undilated images.

Supplemental Table. Comparison of Vertical Optic Disk and Cup Diameters as Measured from Digital Images Through Dark Adapted and Pharmacologically Dilated Pupils

Association Between Severity of Inflammation in CNS and Development of Sunset Glow Fundus in Vogt-Koyanagi-Harada Disease
Hiroshi Keino, MD, Hiroshi Goto, MD, Hideki Mori, MD, Takuya Iwasaki, MD, Masahiko Usui, MD
published June 2006
Full Text | Journal Format-PDF (110Kb)
FIGURE 1S. Distribution of the mean follow up periods. The above figure shows the box-and-whisker plots of the distribution of the mean follow up period. Each box is bound by the 25th and 75th percentile values of the distribution, and the median score is indicated by the horizontal lines through the boxes. The whiskers extend verticaly from the ends of the box to a maximum of 1.5 times the interquartile range (length of the box). There was no significant difference in the mean follow-up period between the patients who developed sunset glow fundus (SGF) (47.8 ± 49.5 months) and those without SGF (i.e. had not developed SGF as of final follow-up) (38 ± 39.5 months) (P = 0.3212, Student t test).

FIGURE 2S. Analysis of visual acuity in both the patients who developed SGF and those without SGF. The above figure shows the life table for the visual acuity of both groups. The y-axis indicates the rates of falling below 20/20. Kaplan-Meier analysis was used. There was no significant difference between the two groups (P = 0.3518).

Autosomal Dominant Cataract: Intrafamilial Phenotypic Variability, Interocular Asymmetry, and Variable Progression in Four Chilean Families
Suraiya M. Shafie, MD, Fernando R. Barria von-Bischhoffshausen, MD, J. Bronwyn Bateman, MD
published April 2006
Full Text | Journal Format-PDF (815Kb)
Supplemental Figure 1. Pedigrees of families ADC51 and ADC52 with autosomal dominant cataracts (ADC).

Supplemental Figure 2. Pedigree of family ADC53 with ADC.

Supplemental Figure 3. Pedigree of family ADC54 with ADC.

Supplemental Figure 4. Family ADC51 with ADC. Phakic eye of a 9-year-old girl (404) with minimal pulverulent opacities in the cortex and a dense posterior subcapsular cataract. She was described as having a dense white cataract in the opposite eye at birth and underwent lensectomy early in life. This individual demonstrates interocular differences in density of opacity and, compared with other individuals in the family, variable location within the lens, morphology, and density.

Supplemental Figure 5. Family ADC52 with ADC. (Top) Left eye with dense, posterior subcapsular circular plaques with defined margins and otherwise clear lens in a 20-year-old woman (312). (Bottom) Right eye with posterior subcapsular cataract with poorly defined borders and white, punctuate opacities in the peripheral lens in the 19-year-old female sibling (313); vacuoles were evident below the anterior capsule. These sisters demonstrate differences in morphology and location of opacities within the lens among individuals within a family. The opacities were symmetric, and neither of the sisters had nystagmus.

Supplemental Figure 6. Family ADC53 with ADC. (Top) Pulverulent opacities in the embryonal region in a 42-year-old (323); the center of the "shell" appears to be clear. (Bottom) Dense embryonal cataract in the right eye of a 27-year-old (311). These male cousins demonstrate differences in density of cataracts of similar morphology and, as compared with other affected family members, differences in morphology, density, and location within the lens.

Supplemental Figure 7. Family ADC53 with ADC. White pulverulent and snowball-like opacities in the cortical region and a dense, star-shaped opacity at the level of the posterior capsule in a 43-year-old man (313). This individual demonstrates differences in morphology, density, and location of cataract within the lens as compared with other members of the family.

Supplemental Figure 8. Family ADC53 with ADC. (Top) The most mildly affected individual, a 6-year-old boy (417), had few white spherical opacities in the anterior and posterior cortex. (Bottom) Similar morphology and location within the lens but the opacities are denser in this 5-year-old girl (403). These individuals demonstrate differences in density of cataracts of similar morphology and, compared with others in the family, differences in location within the lens, density, and morphology.

Supplemental Figure 9. Family ADC53 with ADC. (Top) Mild, bluish pulverulent opacities in the embryonal nuclear and cortical regions in a 5-year-old girl (410); the opacities were densest in a disk-shaped configuration at the level of the posterior subcapsular region. (Bottom) Pulverulent white opacities in a disk-shaped configuration at the level of the posterior subcapsular region and cortical spokelike opacities in a 21-year-old man (425). These individuals demonstrate differences in color and density of similar opacities (disk shaped) and, compared with others in the family, differences in location within the lens and morphology.

Supplemental Figure 10. Family ADC54 with ADC. (Top) Dense embryonal nuclear opacities extending anteriorly to a polar cataract and mild microcornea (diameter 10 mm) in the right eye of a 53-year-old man (217). (Bottom) Left eye of patient 217. The opacity in his right eye was denser and yellow as compared with the left. This individual demonstrates interocular differences in color and, compared with others in the family, differences in location within the lens, color, density, and morphology.

Supplemental Figure 11. ADC54. (Top) Fine embryonal punctate opacities in the only phakic eye of a 39-year-old man (308). The minimal cataract supports the premise that the aphakic eye had a denser cataract before surgery. (Center) Dense embryonal and nuclear cataract in left eye of a 27-year-old man (327). Nystagmus was detected in early visual deprivation, unilateral aphakia, and a dense cataract in the phakic eye. (Bottom) A small, dense embryonal nuclear opacity in a 6-year-old boy (410). This younger individual had relatively small but dense embryonal opacities. These individuals of varying ages underscore differences in density of cataracts of similar morphology and location within the lens and, as compared with other affected members of the family, differences in location within the lens, density, and morphology.

Novel Single-Base Deletional Mutation in Major Intrinsic Protein (MIP) in Autosomal Dominant Cataract
David D. Geyer, BA, M. Anne Spence, PhD, Meriam Johannes, BA, Pamela Flodman, MSc, MS, Kevin P. Clancy, PhD, Rebecca Berry, PhD, Robert S. Sparkes, MD, Matthew D. Jonsen, PhD, Sherwin J. Isenberg, MD, J. Bronwyn Bateman, MD
published April 2006
Full Text | Journal Format-PDF (168Kb)
Supplemental Figure 1. Predicted translational effects of the guanine deletion at position 3223 in exon 4 (arrow), resulting in a substitution of glutamic acid for glycine. The shaded region shows the resultant frameshift and consequent amino acid changes in the mutant allele. Stop codons are boxed, illustrating the introduction of a premature stop codon (nonsense mutation) in the mutant allele.

Orbital Cellulitis in a Patient Receiving Infliximab for Ankylosing Spondylitis
Jonathan C.P. Roos, MA, GIBiol, Andrew J.K. Ostor (FRACP)
published April 2006
Full Text | Journal Format-PDF (968 Kb)
Supplementary material: Full References for Table 1 of Submission AJO-05-1341 (30 KB)

Reply
Samantha Herretes, MD, Walter J. Stark, MD, Peter J. McDonnell, MD, Ashley Behrens, MD
published April 2006
Full Text | Journal Format-PDF (52Kb)
Video 1: Online video (1,656 KB)

A New, X-linked Endothelial Corneal Dystrophy
Eduard Schmid, MD, Walter Lisch, MD, Wolfgang Philipp, MD, Silvia Lechner, BS, Wolfgang Göttinger, MD, Ursula Schlötzer-Schrehardt, PhD, Thomas Müller, MD, Gerd Utermann, MD, Andreas R. Janecke, MD
published March 2006
Full Text | Journal Format-PDF (857Kb)
Supplemental Figure 1. Clinical photographs of two females with X-linked endothelial corneal dystrophy (XECD). (Left) Slit-lamp retroillumination of cornea of female patient IV-6 and (Right) of female patient IV-13 showing endothelial moon crater-like alterations.

Supplemental Figure 2. Slit-lamp appearance of male patient IV-22 with X-linked endothelial corneal dystrophy (XECD). (Left) Clear transplant after penetrating keratoplasty in 1994 with remnants of subpithelial band keratopathy on the host cornea of the left eye. (Middle) Subepithelial band keratopathy on the right eye. (Right) Penetrating keratoplasty in 2003 on the right eye.

Clinical Experience With The Double-Plate Ahmed Glaucoma Valve
Lama A. Al-Aswad, MD, Peter A. Netland, MD, PhD, A. Robert Bellows, MD, Taly Ajdelsztajn, MD, Resham A. Wadhwani, MD, Ghada Ataher, MD, Richard A. Hill, MD
published February 2006
Full Text | Journal Format-PDF (125Kb)
Supplementary Figure 1. Double-plate Ahmed Glaucoma Valve (Model B1, Ahmed Glaucoma Valve with Bi-Plate). The two polypropylene plates have a total surface area of 364 mm2, with one plate containing the Ahmed Glaucoma Valve (surface area = 184 mm2) and an attached second plate (surface area = 180 mm2). The arrows indicate the direction of flow of aqueous from the eye into the device. The tube between the plates may be connected on either side of the valved plate, depending on the intended location of the implant. Adapted from a photograph provided by New World Medical, Inc.

Retinal Pigment Epithelium Tears Following Verteporfin Therapy Combined With Intravitreal Triamcinolone
Stephan Michels, MD, Arne Aue, MD, Christian Simader, MD, Wolfgang Geitzenauer, MD, Stefan Sacu, MD, Ursula Schmidt-Erfurth, MD
published February 2006
Full Text | Journal Format-PDF (544Kb)
Supplemental Figure 1. Early RPE tear following verteporfin monotherapy (Supplemental figure 1). FA documented at baseline a minimally classic CNV (top left and right). At week 1 FA (center left and right) and OCT (bottom) indicated a RPE tear with exposed choroid (between arrows) and a retracted and elevated RPE band.
Supplemental Figure 2. Early RPE tear following combination of PDT and intravitreal triamcinolone (Supplemental figure 2). A predominantly classic CNV was documented at baseline (top left and right). One day following combination therapy increased subretinal fluid was found in OCT (center). A focal adherence was still visible (arrow). At week 1 FA outlined a RPE tear temporal to the fovea (bottom left and right).

Oral Gabapentin Treatment for Symptomatic Heimann-Bielschowsky Phenomenon
Waheeda Rahman, MRCOphth, Frank Proudlock, PhD, Irene Gottlob, MD
published January 2006
Full Text | Journal Format-PDF (106Kb)
Online Video 1: Online video (15,085 KB)
Online Video 2: Online video (9,902 KB)

Pars Plana Vitrectomy With Gas Tamponade for Lamellar Macular Holes
Mayumi Hirakawa, MD, Akinori Uemura, MD, Tetsuro Nakano, MD, Taiji Sakamoto, MD
published December 2005
Full Text | Journal Format-PDF (351Kb)
Supplementary Figure 1. Case 1. (Top) Preoperative fundus photograph showing a sharply defined reddish defect in the inner retinal surface in the foveolar area with an operculum overlying the defect. (Bottom) Fundus photograph 2 years after surgery showing the disappearance of the contour of a lamellar hole with persisted reddish appearance of the foveola. The visual acuity is 1.0.

Supplementary Figure 2. Case 1. Optical coherence tomography (OCT3) image through the fovea 2 years after surgery showing an almost normal configuration of the fovea. (Top) 5-mm horizontal scan. (Bottom) 5-mm vertical scan.

Decision Analysis With Markov Processes Supports Early Surgery for Large-Angle Infantile Esotropia
Thomas A. Trikalinos, MD, Ioanins A. Andreadis, MD, Ioannis C. Asproudis, MD, PhD
published November 2005
Full Text | Journal Format-PDF (533Kb)
Supplementary Figure 1. Schematic outline of the health states and allowed transitions in the Markov processes simulating children with large-angle infantile esotropia.

Supplementary Figure 2. Age-dependent probability to achieve stereopsis for children with large-angle infantile esotropia.

Complications Following Ex-Press Glaucoma Shunt Implantation
Richard M. Stewart, MD, James G. Diamond, MD, Emily D. Ashmore, MD, Ramesh S. Ayyala, MD, FRCS, FRCOphth
published August 2005
Full Text | Journal Format-PDF (108Kb)
Video 1: Online video (35,785 KB)

A Bent Infusion Cannula for Vitreous Surgery
Wen Liu, MD, PhD, Dan-Dan Wang, MS, Su-Ying Huang, MD, Jia-Qing Li, MD, PhD, Su-Hong Wu, MS, Li Hang, MD
published July 2005
Full Text | Journal Format-PDF (144Kb)
Video 1: Video clip (11,006 KB)

Inflow of ocular surface fluid through clear corneal cataract incisions: a laboratory model
Sarayba MA, Taban M, Ignacio TS, Behrens A, McDonnell PJ
published August 2004
Full Text | Journal Format-PDF (258Kb)
Video 1: Miyake view of a globe that demonstrates ink influx through a self-sealing clear corneal incision in response to intraocular pressure fluctuation.
Video 2: Miyake view of a globe that demonstrates ink influx through a self-sealing clear corneal incision in response to manual pressure.

Classification of Farnsworth-Munsell 100-hue test results in the early treatment diabetic retinopathy study
Barton FB, Fong DS, Knatterud GL
published July 2004
Full Text | Journal Format-PDF (258Kb)
Appendix B: Classification of F-M 100-Hue results in ETDRS patients: ocular and patient characteristics of each class of hue impairment in the immediate-treatment group (verification group).

Ocular findings in leprosy patients in nepal in the era of multidrug therapy
Nepal BP, Shrestha UD
published May 2004
Full Text | Journal Format-PDF (93Kb)
Table 1 S: Age and sex distribution of leprosy patients with and without ocular involvement.

Autofluorescence as a novel approach to diagnosing macular holes
Nepal BP, Shrestha UD
published May 2004
Full Text | Journal Format-PDF (417Kb)
Supplementary Material: Abstract
Supplementary Material: AF
Supplementary Material: Disclosure
Figure 1: Findus AF photograph of a normal eye demonstrates reduced AF signal in the foveal area, corresponding to the blockage of AF signal generated in the RPE by the macular pigments.
Figure 2: (A) Fundus AF photograph of the right eye of a patient with MH. There is increased AF signal corresponding to the hole. A halo of hypofluorescence corresponds to the thickening of the neurosensory retina surrounding the MH. (B) Infrared photograph of the same eye also demonstrates the presence of a MH and the surrounding cuff of subretinal fluid. (C) OCT examination of the same eye confirms the presence of a full thickness macular hole. (D) Fundus AF picture of the same eye after vitrectomy surgery reveal persistence of AF signal in the fovea. It appears to be smaller in size than prior to surgery. The linear dark shadow present superiorly corresponds to the level f the intraocular gas (E) Color fundus photographs of the same eye also reveals the presence of a smaller MH and a intraocular gas-fluid level above. (F) OCT examination confirms that the macular hole is still open. (G) Fundus AF photograph of the same eye after the second surgery for repair of the MH demonstrate disappearance of the AF signal in the fovea. (H) The MH appears closed on clinical fundus photograph as well. (I) OCT examination confirms complete closure of the hole.
Figure 3: (A) Fundus AF picture of the left eye of a patient with MH demonstrates a strong AF signal in the fovea. (B) OCT examination of the same eye confirms the presence of a stage 3 MH. There is a partial posterior vitreous separation and an operculum in front of the hole. (C) Fundus AF photograph of the same eye after surgical repair of the MH demonstrates disappearance of the AF signal and restoration of the normal reduction of AF in the fovea. (D) OCT examination of the same eye confirms complete closure of the hole.
Figure 4: (A) Fundus AF photograph of the left eye of a patient with MH reveals increased AF corresponding to the hole. (B) OCT study demonstrates a full thickness MH and partial vitreous separation. (C) Fundus AF study after surgical closure of the hole reveals disappearance of the foveal AF signal and restoration of the normal macular hypofluorescence. (D) OCT study of the same eye confirms complete closure of the MH.
Figure 5: (A) Fundus AF in a patient with MH reveals increased AF corresponding to the hole. (B) OCT examination of the same patient confirms the presence of a stage 3 MH. An operculum is visible in front of the hole. (C) Fundus AF picture after surgical repair of the MH reveals complete disappearance of the AF signal. (D) OCT study confirms the closure of the MH.
Figure 6: (A) Color photograph of a patient with macular pucker and pseudohole. (B) Fundus AF picture of the same eye fails to reveal increased AF signal, consistent with a diagnosis of pseudohole. (C) OCT examination confirms the presence of a pseudohole.

Lipid-lowering drug atorvastatin as an adjunct in the management of diabetic macular edema
Amod Gupta, Vishali Gupta, Shveta Thapar and Anil Bhansali
published April 2004
Full Text | Journal Format-PDF (177Kb)
Image: Photo 1
Image: Photo 2
Image: Photo 3
Image: Photo 4
Image: Photo 5
Image: Photo 6
Image: Photo 7

J. Donald M. Gass, MD: Festschrift editorial
Flynn JT, Clarkson JG, Curtin VT, Flynn HW, Hurtes R, Smith J L
published March 2004
Full Text | Journal Format-PDF (148Kb)
Document 1: J. Donald M. Gass, MD: Curriculum Vitae

Impression cytology in the diagnosis of acanthamoeba keratitis with surface involvement
Sawada Y, Yuan C, Huang AJ W
published February 2004
Abstract | Full Text | Journal Format-PDF (148Kb)
Image 1: Right eye of a 50-year-old female who presented with persistent photophobia and foreign body sensations in both eyes for 3 weeks prior to presentation. A large area of coarse superficial keratopathyin the visulal axis was noted in the visual axis in both eyes. She reported bathing with non-sanitized lake water for a few days after a rain storm about one week before the onset of ocular symptoms. She had no history of contact lens use and was initially treated with topical lubricants and antibiotics without improvement.
Image 2: Righte eye of the same patient. Retroillumination showed diffuse coarse surface irregularities in the central cornea.
Image 3: Impression cytology from the central cornea of the right eye showed numerous relatively larger acanthamoeba cysts with vacuolated cytoplasm and prominent nucleoli among smaller ill-defined corneal epithelial cells. Subsequent corneal scraping also confirmed the growth of Acanthamoeba on the non-nutrient agar plate.
Document 1: Figure Legends

Perfluorocarbon perfused vitrectomy: animal studies
Quiroz-Mercado H, Suarez-Tatá L, Magdalenic R, Murillo-López S, García-Aguirre G, Guerrero-Naranjo J, Rodríguez-Reyes AA
published February 2004
Abstract | Full Text | Journal Format-PDF (148Kb)
Document 1: Figure captions for website pictures
Video 1: Perfluorocarbon perfused vitrectomy: animal studies

Adult-onset acquired oculomotor nerve paresis with cyclic spasms: relationship to ocular neuromyotonia
Miller NR, Lee AG
published January 2004
Abstract | Full Text | Journal Format-PDF (148Kb)
Video 1: Adult-onset acquired oculomotor nerve paresis with cyclic spasms: relationship to ocular neuromyotonia
Video 2: Adult-onset acquired oculomotor nerve paresis with cyclic spasms: relationship to ocular neuromyotonia

Shifting trends in in vitro antibiotic susceptibilities for common ocular isolates during a period of 15 years
Chalita MR, Höfling-Lima AL, Paranhos A, Schor P, Belfort R
published January 2004
Abstract | Full Text | Journal Format-PDF (148Kb)
Image 1: Annual amikacin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 2: Annual gentamicin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 3: Annual neomycin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 4: Annual tobramycin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 5: Annual ciprofloxacin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 6: Annual norfloxacin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 7: Annual ofloxacin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 8: Annual cephalothin susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).
Image 9: Annual chloramphenicol susceptibility to all bacteria tested in corneal and conjunctival samples (1985-2000).

Festschrift: a tribute to the accomplishments of Bradley R. Straatsma, MD, JD
Spivey BE, Liesegang TJ, Holland GN, Bartley GB
published July 2003
Full Text | Journal Format-PDF (148Kb)
PDF: Letter from Bradley R. Straatsma, MD, JD
PDF: Bradley R.Straatsma, MD, JD Curriculum Vitae

An improved technique of eye drop self-administration for patients with limited vision
Robert Ritch, Karim N. Jamal, Rabia Gürses-Özden, Jeffrey M. Liebmann
published April 2003
Abstract | Full Text | Journal Format-PDF (148Kb)
Video: An improved technique of eye drop self-administration for patients with limited vision instructional video.

Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery
Bernd Kirchhof, David Wong, Jan Van Meurs, Ralf D. Hilgers, Marc Macek, Noemi Lois, and Norbert F. Schrage
published January 2002
Abstract | Full Text | Journal Format-PDF (148Kb)
Video: Optimized for 56K modem | Optimized for ISDN Connection | Optimized for T1 Connection

Clinical application of living-related conjunctival-limbal allograft
Kazuo Tsubota, Shigeto Shimmura, Naoshi Shinozaki, Edward J. Holland, and Jun Shimazaki
published January 2002
Abstract | Full Text | Journal Format-PDF (148Kb)
Video: Optimized for 56K modem | Optimized for ISDN Connection | Optimized for T1 Connection

Ocular pulse amplitude in a case of innominate steal syndrome
Claude Kaufmann, Anna Fierz, Spyros S. Kollias, and Yves C.A. Robert
published January 2002
Abstract | Full Text | Journal Format-PDF (148Kb)
Image: Figure 3. Digital subtraction angiography, venous phase, the catheter is placed in the left common carotid artery (not shown on figure). Injection demonstrates retrograde opacification of the cranial branches of the right external carotid artery, indicating the presence of retrograde flow (arrows) in these vessels.

Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel
Douglas A. Jabs, James T. Rosenbaum, C. Stephen Foster, Gary N. Holland, Glenn J. Jaffe, James S. Louie, Robert B. Nussenblatt, E. Richard Stiehm, Howard Tessler, Russell N. Van Gelder, Scott M. Whitcup, and David Yocum
published October 2000
Abstract | Full Text | Journal Format-PDF (311Kb)
Virtual Meeting: Immunosuppressive Drug Therapy for Ocular Disease: An Internet Workshop for Clinicians