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Changing Trends of Blindness: The Initial Harvest From Translational Public Health and Clinical Research in Ophthalmology
All ophthalmologists and vision researchers are aware of the profound adverse effects of blindness on our patients' health and quality of life. From a societal perspective, visual loss comes with an e...
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Ning Cheung,
Tien Yin Wong
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193-195
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| Perspective |
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Avastin Doesn't Blind People, People Blind People
Purpose: To review the appropriate preparation of bevacizumab for intravitreal injection by compounding pharmacies with specific recommendations designed to prevent microbial contamination. Design: Pe...
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Serafin Gonzalez,
Philip J. Rosenfeld,
Michael W. Stewart,
Jennifer Brown,
Steven P. Murphy
et al.
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196-203.e1
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| Original Articles |
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An Outbreak of Streptococcus Endophthalmitis After Intravitreal Injection of Bevacizumab
Purpose: To report a series of patients with Streptococcus endophthalmitis after injection with intravitreal bevacizumab prepared by the same compounding pharmacy. Design: Noncomparative consecutive c...
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Roger A. Goldberg,
Harry W. Flynn,
Ryan F. Isom,
Darlene Miller,
Serafin Gonzalez
et al.
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204-208.e1
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Incidence of Legal Blindness From Age-Related Macular Degeneration in Denmark: Year 2000 to 2010
Purpose: To report incidence rates of legal blindness from age-related macular degeneration (AMD) and other causes in Denmark from years 2000 to 2010 in the age group at risk of AMD aged 50 years and ...
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Sara Brandi Bloch,
Michael Larsen,
Inger Christine Munch
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209-213.e2
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Time Trends in the Incidence and Causes of Blindness in Israel
Purpose: To evaluate time trends in the incidence and causes of new cases of blindness in Israel between 1999 and 2008. Design: Descriptive, retrospective population-based study. Methods: During the d...
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Alon Skaat,
Angela Chetrit,
Michael Belkin,
Michael Kinori,
Ofra Kalter-Leibovici
et al.
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214-221.e1
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Recent Statin Use and Cataract Surgery
07 October 2011
Purpose: To investigate whether the statin class of drugs reduces the risk of cataract extraction. Design: Case-control study. Method: setting: Kaiser Permanente Southern California, which provides pr...
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Donald S. Fong,
Kwun-Yee T. Poon
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222-228.e1
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Punctal and Canalicular Anatomy: Implications for Canalicular Occlusion in Severe Dry Eye
07 October 2011
Purpose: To characterize the microscopic anatomy of the lacrimal punctum and canaliculi in relation to the tarsal plate, muscle of Riolan, and Horner muscle; and to report a novel technique to excise ...
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Hirohiko Kakizaki,
Yasuhiro Takahashi,
Masayoshi Iwaki,
Takashi Nakano,
Ken Asamoto,
Hiroshi Ikeda,
Eiki Goto,
Dinesh Selva,
Igal Leibovitch
et al.
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229-237.e1
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Risk Factors for Orbital Exenteration in Periocular Basal Cell Carcinoma
07 October 2011
Purpose: To present the proportion of patients with periocular basal cell carcinoma (BCC) who underwent orbital exenteration and to evaluate the significance of the following risk factors: initial tum...
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Adriana Iuliano,
Diego Strianese,
Giovanni Uccello,
Agostino Diplomatico,
Sabrina Tebaldi,
Giulio Bonavolontà
et al.
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238-241.e1
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Clinicopathologic and Immunohistochemical Features of Pigmented Basal Cell Carcinomas of the Eyelids
07 October 2011
Purpose: To describe the clinical and microscopic features of pigmented basal cell carcinomas (pBCC) of the eyelid. Design: Retrospective observational case series collected at one institution. Method...
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Maria Kirzhner,
Frederick A. Jakobiec
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242-252.e2
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Clinical Significance of Microbial Growth on the Surfaces of Silicone Tubes Removed From Dacryocystorhinostomy Patients
14 September 2011
Purpose: To investigate the bacterial infection of silicone tubes removed from patients who underwent dacryocystorhinostomy (DCR) and assess the correlation between the culture results and postoperati...
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Sung Eun Kim,
Sung Jun Lee,
Sang Yeul Lee,
Jin Sook Yoon
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253-257.e1
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The Effect of Standard and Transepithelial Ultraviolet Collagen Cross-Linking on Human Corneal Nerves: An Ex Vivo Study
19 September 2011
Purpose: To evaluate the early effect of standard and transepithelial collagen cross-linking on human corneal nerves in donor eyes by ex vivo confocal microscopy and acetylcholinesterase staining. Des...
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Mouhamed Al-Aqaba,
Roberta Calienno,
Usama Fares,
Ahmad Muneer Otri,
Leonardo Mastropasqua,
Mario Nubile,
Harminder S. Dua
et al.
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258-266.e2
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Prevalence, Progression, and Impact of Glaucoma on Vision After Boston Type 1 Keratoprosthesis Surgery
10 October 2011
Purpose: To report glaucoma outcomes after Boston type 1 keratoprosthesis (KPro) surgery, in particular, glaucoma prevalence, progression, and treatment. Design: Consecutive, retrospective, interventi...
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Julia C. Talajic,
Younes Agoumi,
Sébastien Gagné,
Krystel Moussally,
Mona Harissi-Dagher
et al.
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267-274.e1
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Micrometer-Scale Contact Lens Movements Imaged by Ultrahigh-resolution Optical Coherence Tomography
14 September 2011
Purpose: To dynamically evaluate contact lens movement and ocular surface shape using ultrahigh-resolution and ultralong-scan-depth optical coherence tomography (OCT). Design: Clinical research study ...
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Lele Cui,
Meixiao Shen,
Michael R. Wang,
Jianhua Wang
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275-283.e1
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Reporting Visual Acuities
The AJO encourages authors to report the visual acuity in the manuscript using the same nomenclature that was used in gathering the data provided they were recorded in one of the methods listed here. ...
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283
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Characteristic Higher-Order Aberrations of the Anterior and Posterior Corneal Surfaces in 3 Corneal Transplantation Techniques
07 October 2011
Purpose: To investigate the corneal higher-order aberrations (HOAs) of the anterior and posterior corneal surfaces in eyes that underwent penetrating keratoplasty (PK), deep anterior lamellar keratopl...
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Shizuka Koh,
Naoyuki Maeda,
Tomoya Nakagawa,
Ritsuko Higashiura,
Makoto Saika,
Toshifumi Mihashi,
Takashi Fujikado,
Kohji Nishida
et al.
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284-290.e1
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Long-term Comparison of Full-Bed Deep Lamellar Keratoplasty With Penetrating Keratoplasty in Treating Corneal Leucoma Caused by Herpes Simplex Keratitis
13 October 2011
Purpose: To compare long-term outcomes of full-bed deep lamellar keratoplasty (DLK) with penetrating keratoplasty (PK) for treating corneal leucoma caused by herpes simplex keratitis (HSK). Design: Re...
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Shuang-Qing Wu,
Ping Zhou,
Bei Zhang,
Wen-Ya Qiu,
Yu-Feng Yao
et al.
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291-299.e2
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Intravitreal Bevacizumab for Treatment of Subfoveal Idiopathic Choroidal Neovascularization: Results of a 1-Year Prospective Trial
07 October 2011
Purpose: To evaluate the visual and anatomic outcomes of intravitreal bevacizumab in patients with subfoveal idiopathic choroidal neovascularization (CNV). Design: Prospective, nonrandomized, interven...
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Han Zhang,
Zhe-Li Liu,
Peng Sun,
Feng Gu
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300-306.e1
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Vascular Endothelial Growth Factor in Plasma and Vitreous Fluid of Patients with Proliferative Diabetic Retinopathy Patients after Intravitreal Injection of Bevacizumab
10 October 2011
Purpose: To investigate plasma and vitreous vascular endothelial growth factor (VEGF) levels after intravitreal bevacizumab (IVB) injection into eyes with proliferative diabetic retinopathy (PDR). Des...
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Yan Ma,
Yan Zhang,
Tong Zhao,
Yan-rong Jiang
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307-313.e2
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Near-Infrared Autofluorescence in Patients With Idiopathic Submacular Choroidal Neovascularization
10 October 2011
Purpose: To investigate near-infrared autofluorescence (IR-AF) patterns and related changes in patients with idiopathic choroidal neovascularization (CNV) treated with intravitreal bevacizumab (IVB). ...
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Ryoko Toju,
Tomohiro Iida,
Tetsuju Sekiryu,
Masaaki Saito,
Ichiro Maruko,
Mariko Kano
et al.
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314-319
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Vitrectomy and Internal Limiting Membrane Peeling With and Without Gas Tamponade for Myopic Foveoschisis
10 October 2011
Purpose: To compare clinical outcomes after vitrectomy and internal limiting membrane (ILM) peeling, with and without gas tamponade, for the treatment of myopic foveoschisis. Design: Retrospective, co...
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Kyu Seop Kim,
Seung Bum Lee,
Won Ki Lee
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320-326.e1
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Serum Concentrations of Bevacizumab (Avastin) and Vascular Endothelial Growth Factor in Infants With Retinopathy of Prematurity
19 September 2011
Purpose: To determine the serum concentrations of bevacizumab and vascular endothelial growth factor (VEGF) in infants with retinopathy of prematurity (ROP) who received intravitreal bevacizumab; and ...
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Tatsuhiko Sato,
Kazuko Wada,
Hitomi Arahori,
Noriyuki Kuno,
Kenji Imoto,
Chiharu Iwahashi-Shima,
Shunji Kusaka
et al.
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327-333.e1
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Prediction of Postoperative Eyelid Height After Frontalis Suspension Using Autogenous Fascia Lata for Pediatric Congenital Ptosis
10 October 2011
Purpose: To predict eyelid height after frontalis suspension using autogenous fascia lata for congenital ptosis. Design: Retrospective, observational case series. Methods: Eighty eyes of 54 children w...
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Chang Yeom Kim,
Jin Sook Yoon,
Jong-Myon Bae,
Sang Yeul Lee
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334-342.e2
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The Long-Term Survival Analysis of Bilateral Lateral Rectus Recession Versus Unilateral Recession-Resection for Intermittent Exotropia
07 October 2011
Purpose: To conduct a comparison of the long-term surgical outcomes of bilateral lateral rectus recession (BLR) vs unilateral lateral rectus recession–medial rectus resection (RR) in treatment of inte...
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Jin Choi,
Ji Woong Chang,
Seong-Joon Kim,
Young Suk Yu
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343-351.e1
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Subconjunctival Bevacizumab Versus Mitomycin C Adjunctive to Trabeculectomy
10 October 2011
Purpose: To compare the outcome of trabeculectomy with subconjunctival bevacizumab with that of trabeculectomy with mitomycin C (MMC). Design: Prospective, randomized, comparative study. Methods: Thir...
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Naveed Nilforushan,
Maryam Yadgari,
Shahin Khosh Kish,
Nariman Nassiri
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352-357.e1
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Corneal Hysteresis and Beta-Zone Parapapillary Atrophy
14 September 2011
Purpose: To evaluate the relationship between β-zone parapapillary atrophy (βPPA) and corneal hysteresis (CH) in patients with glaucoma. Design: Prospective, cross-sectional study. Methods: Glaucoma p...
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Daniel D. Hayes,
Christopher C. Teng,
Carlos Gustavo de Moraes,
Celso Tello,
Jeffrey M. Liebmann,
Robert Ritch
et al.
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358-362.e1
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Ocular Complications of Human Immunodeficiency Virus Infection in Eastern China
07 October 2011
Purpose: To investigate ocular complications in patients with HIV/AIDS in eastern China during the time of highly active antiretroviral therapy (HAART). Design: Prospective study. Methods: This study ...
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Zhiliang Wang,
Renbing Jia,
Shengfang Ge,
Taiwen He,
Yunzhi Zhang,
Yaling Yang,
Yefei Wang,
Wodong Shi,
Yongrong Ji,
Fuxiang Ye,
Ping Chen,
Jianfeng Lu,
Jing Sun,
Xiaofang Xu,
Yixiong Zhou,
Ping Gu,
Min Luo,
Hongzhou Lu,
Xianqun Fan
et al.
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363-369.e1
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Depression and Visual Functioning in Patients With Ocular Inflammatory Disease
15 September 2011
Purpose: To characterize the level of depression in patients with ocular inflammatory disease and to determine predictors of depression in this population. Design: Prospective cross-sectional survey a...
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Ying Qian,
Tanya Glaser,
Elizabeth Esterberg,
Nisha R. Acharya
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370-378.e2
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| Correspondence |
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In Vivo Analysis of Stromal Integration of Multilayer Amniotic Membrane Transplantation in Corneal Ulcers
Nubile and associates recently published an interesting study evaluating the integration of amniotic membrane into the corneal stroma after amniotic membrane transplantation for persistent noninfectio...
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Zisis Gatzioufas,
Marlies Sauter,
Andrea Hasenfus,
Sigrun Smola,
Berthold Seitz
et al.
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379
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Reply
We appreciate the interest and comments of Gatzioufas and associates concerning our article, “In Vivo Analysis of Stromal Integration of Multilayer Amniotic Membrane Transplantation in Corneal Ulcers,...
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Mario Nubile,
Manuela Lanzini,
Marco Ciancaglini,
Roberta Calienno,
Rodolfo Mastropasqua,
Paolo Carpineto,
Harminder S. Dua,
Dalia G. Said,
Augusto Pocobelli
et al.
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379-380
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Quality of Life in a German Graves Orbitopathy Population
We read with great interest the recent report by Ponto and associates describing the quality of life of patients with thyroid orbitopathy in a German population. We would like to point out to the read...
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Renelle Pointdujour,
Justin Gutman,
Roman Shinder
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380-381
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Reply
Pointdujour and associates argue that the term Graves orbitopathy (GO) “leads to confusion and misdiagnoses among many medical specialists.” We agree that there are several reasons why the term Graves...
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Katharina A. Ponto,
George J. Kahaly
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381
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Blindness and Long-term Progression of Visual Field Defects in Chinese Patients With Primary Angle-Closure Glaucoma
I read with interest the article by Quek and associates regarding the long-term progression of primary angle-closure glaucoma in Chinese patients. For some time there has been a need for long-term stu...
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Aparna Rao
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382
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Reply
We thank Dr Rao for the interest in our article. Dr Rao found it surprising that the mean intraocular pressure (IOP) and range of IOP were not significant risk factors for visual field progression in ...
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Desmond T.L. Quek,
Shamira A. Perera,
Tin Aung
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382-383
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Corneal Thickness Change in Eyes Undergoing Corneal Cross-Linking
I read with interest the recent work by Holopainen and Krootila and would like to ask the authors to clarify some points about their study and offer comments on their findings. The authors stated in t...
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Zhen-Yong Zhang
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383
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Reply
We thank Dr Zhang for his interest in our article. We agree that especially in keratoconic corneas, the thickness of the cornea may be very different on different areas of the cornea, and that is why ...
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Juha M. Holopainen,
Kari Krootila
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383-384
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Use of Infliximab in the Treatment of Peripheral Ulcerative Keratitis in Crohn Disease
We read with great interest the article “Use of Infliximab in the Treatment of Peripheral Ulcerative Keratitis in Crohn Disease,” published in August 2011 issue of the Journal. We appreciate the autho...
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Archana Singh,
Virender S. Sangwan
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384
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Reply
We thank Drs Singh and Sangwan for their interest in our article, “Use of Infliximab in the Treatment of Peripheral Ulcerative Keratitis in Crohn Disease,” and are heartened that they have found a sim...
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Elmer Y. Tu,
Mary Pham,
Clement C. Chow,
David Badawi
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384-385
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Oral Mucosal Graft to Correct Lid Margin Pathologic Features in Cicatricial Ocular Surface Diseases
The article by Fu and associates evaluating the oral mucosal graft in cicatricial ocular surface reconstruction is very interesting. The lamellar division of the eyelid at the grey line with repositio...
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Saurabh Kamal,
Sushil Kumar
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386
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Reply
I thank Drs Kamal and Kumar for their interest in our recently published article. I am pleased to learn that they also found our surgical technique useful in correcting lid margin deformity, lid retra...
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Scheffer C.G. Tseng
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386-387
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Possible Short-term Changes of Aqueous Inflammatory Cytokines After Intravitreal Bevacizumab for Diabetic Macular Edema
We read with great interest the article by Sohn and associates, “Changes in Aqueous Concentrations of Various Cytokines after Intravitreal Triamcinolone versus Bevacizumb for Diabetic Macular Edema.” ...
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Won June Lee,
Hee Yoon Cho
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387-388
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Reply
We appreciate the comments of Lee and Cho regarding short-term changes of aqueous inflammatory cytokines after intravitreal bevacizumab (IVB) for diabetic macular edema, and their remarks about possib...
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Hee Jin Sohn,
In Kyung Oh,
Dae Heon Han,
Kyun Hyung Kim,
Dae Yeong Lee,
Dong Heun Nam,
Im Tae Kim
et al.
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388
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Natural Course of Adult-Onset Foveomacular Vitelliform Dystrophy: A Spectral-Domain Optical Coherence Tomography Analysis
We read with great interest the article by Querques and associates describing progressive stages in patients with presumed adult-onset foveomacular vitelliform dystrophy (AOFVD): vitelliform, pseudohy...
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Rosa Dolz-Marco,
Roberto Gallego-Pinazo,
Manuel Díaz-Llopis
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389
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Reply
We thank Dolz-Marco and associates for their interest in and comments on our recent article on the natural course of adult-onset foveomacular vitelliform dystrophy (AOFVD) by spectral-domain optical c...
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Giuseppe Querques,
Lea Querques,
Eric H. Souied
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389-390
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A4
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