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Combined Esterified Estrogen and Methyltestosterone Treatment for Dry Eye Syndrome in Postmenopausal Women

      Purpose

      To determine whether systemic replacement with combined esterified estrogen (EE) and methyltestosterone (MT) (EE + MT) would reduce symptoms and promote clinical improvement in postmenopausal women with dry eye syndrome (DES).

      Design

      Retrospective, noncomparative, interventional case series.

      Methods

      Investigators reviewed the charts of 11 postmenopausal women treated within the last 3 years with EE + MT.

      Results

      The mean patient age was 65.2 years (standard deviation [SD] 11.4, range 48–84 years). The mean treatment duration was 12.2 months (SD 6.2 months, range 4–24 months). Ten (91%) of 11 patients reported improvement in dry eye symptoms while receiving treatment. For these 10, relief occurred after an average of 4.1 months of treatment (SD 3.2, range, 1–9 months).

      Conclusions

      Treatment with EE + MT may be efficacious for DES of various etiologies. A randomized placebo-controlled trial is planned to further evaluate these encouraging findings.
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