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Dry Eye in the Beaver Dam Offspring Study: Prevalence, Risk Factors, and Health-Related Quality of Life

Published:January 03, 2014DOI:https://doi.org/10.1016/j.ajo.2013.12.023

      Purpose

      To estimate dry eye prevalence in the Beaver Dam Offspring Study (BOSS), including a young adult population, and investigate associated risk factors and impact on health-related quality of life.

      Design

      Cohort study.

      Methods

      The BOSS (2005-2008) is a study of aging in the adult offspring of the population-based Epidemiology of Hearing Loss Study cohort. Questionnaire data on health history, medication use, risk factors, and quality of life were available for 3275 participants. Dry eye was determined by self-report of frequency of symptoms and the intensity of those symptoms. Associations between dry eye and risk factors were analyzed using logistic regression.

      Results

      The prevalence of dry eye in the BOSS was 14.5%: 17.9% of women and 10.5% of men. In a multivariate model, statistically significant associations were found with female sex (odds ratio [OR], 1.68; 95% confidence interval [CI], 1.33-2.11), current contact lens use (OR, 2.01; 95% CI, 1.53-2.64), allergies (OR, 1.59; 95% CI, 1.22-2.08), arthritis (OR, 1.44; 95% CI, 1.12-1.85), thyroid disease (OR, 1.43; 95% CI, 1.02-1.99), antihistamine use (OR, 1.54; 95% CI, 1.18-2.02), and steroid use (OR, 1.54; 95% CI, 1.16-2.06). Dry eye was also associated with lower scores on the Medical Outcomes Study Short Form 36 (β = −3.9, P < .0001) as well as on the National Eye Institute 25-Item Visual Function Questionnaire (NEI VFQ-25) (β = −3.4, P < .0001) when controlling for age, sex, and comorbid conditions.

      Conclusions

      The prevalence of dry eye and its associated risk factors in the BOSS were similar to previous studies. In this study, dry eye was associated with lower quality of life on a health-related quality-of-life instrument and the vision-specific NEI VFQ-25.
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      References

      1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye Workshop (2007).
        Ocul Surf. 2007; 5: 75-92
        • Begley C.G.
        • Caffery B.
        • Chalmers R.L.
        • Mitchell G.L.
        Use of the dry eye questionnaire to measure symptoms of ocular irritation in patients with aqueous tear deficient dry eye.
        Cornea. 2002; 21: 664-670
        • Moss S.E.
        • Klein R.
        • Klein B.E.
        Prevalence of and risk factors for dry eye syndrome.
        Arch Ophthalmol. 2000; 118: 1264-1268
        • Chia E.M.
        • Mitchell P.
        • Rochtchina E.
        • Lee A.J.
        • Maroun R.
        • Wang J.J.
        Prevalence and associations of dry eye syndrome in an older population: the Blue Mountains Eye Study.
        Clin Experiment Ophthalmol. 2003; 31: 229-232
        • Guo B.
        • Lu P.
        • Chen X.
        • Zhang W.
        • Chen R.
        Prevalence of dry eye disease in Mongolians at high altitude in China: the Henan eye study.
        Ophthalmic Epidemiol. 2010; 17: 234-241
        • Galor A.
        • Feuer W.
        • Lee D.J.
        • et al.
        Prevalence and risk factors of dry eye syndrome in a United States veterans affairs population.
        Am J Ophthalmol. 2011; 152: 377-384
        • Uchino M.
        • Nishiwaki Y.
        • Michikawa T.
        • et al.
        Prevalence and risk factors of dry eye disease in Japan: Koumi study.
        Ophthalmology. 2011; 118: 2361-2367
        • Lekhanont K.
        • Rojanaporn D.
        • Chuck R.S.
        • Vongthongsri A.
        Prevalence of dry eye in Bangkok, Thailand.
        Cornea. 2006; 25: 1162-1167
        • Viso E.
        • Rodriguez-Ares M.T.
        • Gude F.
        Prevalence of and associated factors for dry eye in a Spanish adult population (The Salnes Eye Study).
        Ophthalmic Epidemiol. 2009; 16: 15-21
        • Schiffman R.M.
        • Walt J.G.
        • Jacobsen G.
        • Doyle J.J.
        • Lebovics G.
        • Sumner W.
        Utility assessment among patients with dry eye disease.
        Ophthalmology. 2003; 110: 1412-1419
        • Vitale S.
        • Goodman L.A.
        • Reed G.F.
        • Smith J.A.
        Comparison of the NEI-VFQ and OSDI questionnaires in patients with Sjögren’s syndrome-related dry eye.
        Health Qual Life Outcomes. 2004; 2: 44
        • Le Q.
        • Zhou X.
        • Ge L.
        • Wu L.
        • Hong J.
        • Xu J.
        Impact of dry eye syndrome on vision-related quality of life in non-clinic-based general population.
        BMC Ophthalmol. 2012; 12: 22
        • Li M.
        • Gong L.
        • Sun X.
        • Chapin W.J.
        Anxiety and depression in patients with dry eye syndrome.
        Curr Eye Res. 2011; 36: 1-7
        • Rajagopalan K.
        • Abetz L.
        • Mertzanis P.
        • et al.
        Comparing the discriminative validity of two generic and one disease-specific health-related quality of life measures in a sample of patients with dry eye.
        Value Health. 2005; 8: 168-174
        • Ware J.E.
        • Snow K.K.
        • Kosinski M.
        • Gandek B.
        Chapter 6: Scoring the SF-36.
        in: SF-36 Health Survey Manual and Interpretation Guide. 6. The Health Institute, New England Medical Center, Boston1993: 1-6 (22)
        • Ware J.E.
        • Kosinski M.
        • Keller S.D.
        Chapter 7: Interpretation: content- and criterion-based.
        in: SF-36 Physical and Mental Health Summary Scales: A User's Manual. 7. The Health Assessment Lab, New England Medical Center, Boston1994: 1-7 (32)
        • Mangione C.M.
        • Lee P.P.
        • Gutierrez P.R.
        • Spritzer K.
        • Berry S.
        • Hays R.D.
        Development of the 25-item National Eye Institute Visual Function Questionnaire.
        Arch Opththalmol. 2001; 119: 1050-1058
        • Mizuno Y.
        • Yamada M.
        • Miyake Y.
        Association between clinical diagnostic tests and health-related quality of life surveys in patients with dry eye syndrome.
        Jpn J Ophthalmol. 2010; 54: 259-265
        • Miljanović B.
        • Dana R.
        • Sullivan D.A.
        • Schaumberg D.A.
        Impact of dry eye syndrome on vision-related quality of life.
        Am J Ophthalmol. 2007; 143: 409-415
        • Schaumberg D.A.
        • Buring J.E.
        • Sullivan D.A.
        • Dana M.R.
        Hormone replacement therapy and dry eye syndrome.
        JAMA. 2001; 286: 2114-2119
        • Koktekir B.E.
        • Celik G.
        • Karalezli A.
        • Kal A.
        Dry eyes and migraines: is there really a correlation?.
        Cornea. 2012; 31: 1414-1416
        • Moss S.E.
        • Klein R.
        • Klein B.E.
        Incidence of dry eye in an older population.
        Arch Ophthalmol. 2004; 122: 369-373
        • Schaumberg D.A.
        • Sullivan D.A.
        • Buring J.E.
        • Dana M.R.
        Prevalence of dry eye syndrome among US women.
        Am J Opthalmol. 2003; 136: 318-326
        • Bandeen-Roche K.
        • Muñoz B.
        • Tielsch J.M.
        • West S.K.
        • Schein O.D.
        Self-reported assessment of dry eye in a population-based setting.
        Invest Ophthalmol Vis Sci. 1997; 38: 2469-2475
        • Nichols K.K.
        • Mitchell G.L.
        • Zadnik K.
        The repeatability of clinical measurements of dry eye.
        Cornea. 2004; 23: 272-285
        • Begley C.G.
        • Chalmers R.L.
        • Abetz L.
        • et al.
        The relationship between habitual patient-reported symptoms and clinical signs among patients with dry eye of varying severity.
        Invest Ophthalmol Vis Sci. 2003; 44: 4753-4761
        • Nichols J.J.
        • Mitchell G.L.
        • Nichols K.K.
        An assessment of self-reported disease classification in epidemiological studies of dry eye.
        Invest Ophthalmol Vis Sci. 2004; 45: 3453-3457
        • Hay E.M.
        • Thomas E.
        • Pal B.
        • Hajeer A.
        • Chambers H.
        • Silman A.J.
        Weak association between subjective symptoms of and objective testing for dry eyes and dry mouth: results from a population based study.
        Ann Rheum Dis. 1998; 57: 20-24
        • Cardona G.
        • Marcellán C.
        • Fornieles A.
        • Vilaseca M.
        • Quevedo L.
        Temporal stability in the perception of dry eye ocular discomfort symptoms.
        Optom Vis Sci. 2010; 87: 1023-1029
        • Chalmers R.L.
        • Begley C.G.
        • Edrington T.
        • et al.
        The agreement between self-assessment and clinician assessment of dry eye severity.
        Cornea. 2005; 24: 804-810