Advertisement

Retrospective Validation of the Postnatal Growth and Retinopathy of Prematurity (G-ROP) Criteria in a Japanese Cohort

Published:April 04, 2019DOI:https://doi.org/10.1016/j.ajo.2019.03.027

      Purpose

      We aimed to externally validate the performance of new screening criteria for retinopathy of prematurity (ROP) developed in the Postnatal Growth and Retinopathy of Prematurity (G-ROP) study among a Japanese cohort.

      Design

      Validation of screening criteria.

      Methods

      We reviewed premature infants screened for ROP between September 2009 and May 2017 at a single institution. The G-ROP criteria, except hydrocephalus, were applied as a prediction model for infants with both a known outcome of ROP and serial measurements of weight gain. We assessed sensitivity and specificity for treatment-requiring ROP, and reduction in the number of infants who receive ROP screening and in the number of retinal examinations.

      Results

      Of 692 premature infants screened for ROP, 537 had information of ROP outcome and weight gain. In this cohort, 81 infants required treatment for ROP; in 218 infants, ROP regressed spontaneously; and 238 infants did not develop any ROP. The G-ROP model reached a sensitivity of 100% (95% confidence interval [CI], 95.4%-100%) and specificity of 28.9% (95% CI, 24.9%-33.2%). No infants required any treatment for ROP before the date of risk determination. The number of infants requiring screening and the number of examinations would have been reduced by 24.5% and 12.9%, respectively.

      Conclusions

      This is the first validation study of the G-ROP criteria in a developed country other than North America. The criteria demonstrated high sensitivity in this Japanese cohort, even though the criterion of hydrocephalus was excluded.
      To read this article in full you will need to make a payment

      References

        • Blencowe H.
        • Lawn J.E.
        • Vazquez T.
        • Fielder A.
        • Gilbert C.
        Preterm-associated visual impairment and estimates of retinopathy of prematurity at regional and global levels for 2010.
        Pediatr Res. 2013; 74: 35-49
        • Husain S.M.
        • Sinha A.K.
        • Bunce C.
        • et al.
        Relationships between maternal ethnicity, gestational age, birth weight, weight gain, and severe retinopathy of prematurity.
        J Pediatr. 2013; 163: 67-72
        • Chan-Ling T.
        • Gole G.A.
        • Quinn G.E.
        • Adamson S.J.
        • Darlow B.A.
        Pathophysiology, screening and treatment of ROP: a multi-disciplinary perspective.
        Prog Retin Eye Res. 2018; 62: 77-119
        • Wilkinson A.R.
        • Haines L.
        • Head K.
        • Fielder A.R.
        UK retinopathy of prematurity guideline.
        Early Hum Dev. 2008; 84: 71-74
        • Fierson W.M.
        American Academy of Pediatrics Section on Ophthalmology, American Academy of Ophthalmology, American Association for Pediatric Ophthalmology and Strabismus, American Association of Certified Orthoptists. Screening examination of premature infants for retinopathy of prematurity.
        Pediatrics. 2013; 131: 189-195
        • Holmstrom G.E.
        • Hellstrom A.
        • Jakobsson P.G.
        • Lundgren P.
        • Tornqvist K.
        • Wallin A.
        Swedish national register for retinopathy of prematurity (SWEDROP) and the evaluation of screening in Sweden.
        Arch Ophthalmol. 2012; 130: 1418-1424
        • Binenbaum G.
        • Bell E.F.
        • Donohue P.
        • et al.
        Development of modified screening criteria for retinopathy of prematurity: primary results from the Postnatal Growth and Retinopathy of Prematurity Study.
        JAMA Ophthalmol. 2018; 136: 1034-1040
        • International Committee for the Classification of Retinopathy of Prematurity
        The International Classification of Retinopathy of Prematurity revisited.
        Arch Ophthalmol. 2005; 123: 991-999
        • Good W.V.
        • Hardy R.J.
        • et al.
        • Early Treatment for Retinopathy of Prematurity Cooperative Group
        Final visual acuity results in the early treatment for retinopathy of prematurity study.
        Arch Ophthalmol. 2010; 128: 663-671
        • Fenton T.R.
        A new growth chart for preterm babies: Babson and Benda’s chart updated with recent data and a new format.
        BMC Pediatr. 2003; 3: 13