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Choroidal Detachment Following the Use of Tamsulosin (Flomax)

Published:October 23, 2006DOI:https://doi.org/10.1016/j.ajo.2006.09.032

      Purpose

      To report choroidal detachment following tamsulosin (Flomax, an α1A-adrenoceptor antagonist) treatment of benign prostatic hyperplasia (BPH).

      Design

      Case report.

      Methods

      Chart review, serial examination.

      Results

      A 65-year-old man underwent uncomplicated cataract extraction and placement of a posterior chamber intraocular lens. The patient subsequently developed three separate episodes of choroidal detachments in the operated eye. Each episode was preceded by treatment with an α1-adrenoceptor antagonist.

      Conclusions

      Tamsulosin may cause adverse ocular effects including recurrent choroidal detachments. α1A is the dominant α-adrenoceptor in the rabbit choroid, and the mechanism for choroidal detachment in this patient could include some effect of antagonists like tamsulosin on these receptors.
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